| Full name: calponin 1 | Alias Symbol: SMCC|Sm-Calp | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 1264 | HGNC ID: HGNC:2155 | Ensembl Gene: ENSG00000130176 | OMIM ID: 600806 |
| Drug and gene relationship at DGIdb | |||
Expression of CNN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNN1 | 1264 | 203951_at | -2.5364 | 0.1640 | |
| GSE20347 | CNN1 | 1264 | 203951_at | -1.0372 | 0.0397 | |
| GSE23400 | CNN1 | 1264 | 203951_at | -1.4336 | 0.0000 | |
| GSE26886 | CNN1 | 1264 | 203951_at | 0.7249 | 0.0798 | |
| GSE29001 | CNN1 | 1264 | 203951_at | -0.7289 | 0.0992 | |
| GSE38129 | CNN1 | 1264 | 203951_at | -1.5945 | 0.0097 | |
| GSE45670 | CNN1 | 1264 | 203951_at | -4.4253 | 0.0000 | |
| GSE63941 | CNN1 | 1264 | 203951_at | -1.7587 | 0.0111 | |
| GSE77861 | CNN1 | 1264 | 203951_at | 0.2823 | 0.2634 | |
| GSE97050 | CNN1 | 1264 | A_23_P125233 | -1.5864 | 0.1186 | |
| SRP007169 | CNN1 | 1264 | RNAseq | 3.2342 | 0.0000 | |
| SRP008496 | CNN1 | 1264 | RNAseq | 3.7654 | 0.0000 | |
| SRP064894 | CNN1 | 1264 | RNAseq | -1.5855 | 0.0004 | |
| SRP133303 | CNN1 | 1264 | RNAseq | -2.9361 | 0.0000 | |
| SRP159526 | CNN1 | 1264 | RNAseq | -1.8874 | 0.0224 | |
| SRP219564 | CNN1 | 1264 | RNAseq | -1.8701 | 0.1420 | |
| TCGA | CNN1 | 1264 | RNAseq | -0.8868 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 8.
Survival by CNN1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CNN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNN1 | 1264 | 4 | 2 | 24 | |
| GSE20123 | CNN1 | 1264 | 3 | 1 | 26 | |
| GSE43470 | CNN1 | 1264 | 2 | 6 | 35 | |
| GSE46452 | CNN1 | 1264 | 47 | 1 | 11 | |
| GSE47630 | CNN1 | 1264 | 4 | 7 | 29 | |
| GSE54993 | CNN1 | 1264 | 16 | 3 | 51 | |
| GSE54994 | CNN1 | 1264 | 6 | 13 | 34 | |
| GSE60625 | CNN1 | 1264 | 9 | 0 | 2 | |
| GSE74703 | CNN1 | 1264 | 2 | 4 | 30 | |
| GSE74704 | CNN1 | 1264 | 0 | 1 | 19 | |
| TCGA | CNN1 | 1264 | 16 | 12 | 68 |
Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.
Somatic mutations of CNN1:
Generating mutation plots.
Highly correlated genes for CNN1:
Showing top 20/1063 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNN1 | FILIP1 | 0.936964 | 3 | 0 | 3 |
| CNN1 | ACTG2 | 0.909465 | 11 | 0 | 11 |
| CNN1 | LMOD1 | 0.907016 | 11 | 0 | 11 |
| CNN1 | MYOCD | 0.878184 | 5 | 0 | 5 |
| CNN1 | PLN | 0.871565 | 11 | 0 | 11 |
| CNN1 | LONRF2 | 0.866807 | 3 | 0 | 3 |
| CNN1 | RASSF3 | 0.865996 | 3 | 0 | 3 |
| CNN1 | CHRDL1 | 0.865306 | 8 | 0 | 8 |
| CNN1 | MYH11 | 0.864068 | 10 | 0 | 10 |
| CNN1 | AFF3 | 0.858882 | 3 | 0 | 3 |
| CNN1 | TAGLN | 0.855318 | 10 | 0 | 10 |
| CNN1 | SYNM | 0.850496 | 10 | 0 | 10 |
| CNN1 | MSRB3 | 0.845385 | 5 | 0 | 5 |
| CNN1 | DES | 0.844739 | 11 | 0 | 10 |
| CNN1 | TNS1 | 0.841179 | 9 | 0 | 9 |
| CNN1 | FLNC | 0.839925 | 10 | 0 | 10 |
| CNN1 | PRUNE2 | 0.838935 | 11 | 0 | 11 |
| CNN1 | MRVI1 | 0.831769 | 6 | 0 | 6 |
| CNN1 | ZNF347 | 0.826221 | 3 | 0 | 3 |
| CNN1 | NEXN | 0.825033 | 7 | 0 | 7 |
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