MAP2K7

 

Full name: mitogen-activated protein kinase kinase 7 Alias Symbol: MKK7|Jnkk2
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 5609 HGNC ID: HGNC:6847 Ensembl Gene: ENSG00000076984 OMIM ID: 603014
Drug and gene relationship at DGIdb
Screen Evidence:

 

MAP2K7 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04912GnRH signaling pathway
hsa05164Influenza A
hsa05169Epstein-Barr virus infection

 

Expression of MAP2K7:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAP2K7 5609 226053_at 0.3907 0.4009
GSE20347 MAP2K7 5609 216206_x_at 0.1212 0.5248
GSE23400 MAP2K7 5609 209951_s_at -0.2475 0.0000
GSE26886 MAP2K7 5609 226023_at 0.3267 0.0268
GSE29001 MAP2K7 5609 216206_x_at 0.2331 0.2987
GSE38129 MAP2K7 5609 216206_x_at 0.0171 0.9397
GSE45670 MAP2K7 5609 226023_at 0.0519 0.6019
GSE53622 MAP2K7 5609 25084 -0.0190 0.7741
GSE53624 MAP2K7 5609 25084 0.3850 0.0000
GSE63941 MAP2K7 5609 226053_at 1.1311 0.0013
GSE77861 MAP2K7 5609 226023_at -0.0368 0.8642
GSE97050 MAP2K7 5609 A_33_P3236651 -0.1263 0.5947
SRP007169 MAP2K7 5609 RNAseq -0.3233 0.3910
SRP008496 MAP2K7 5609 RNAseq -0.3362 0.1726
SRP064894 MAP2K7 5609 RNAseq 0.3640 0.0426
SRP133303 MAP2K7 5609 RNAseq -0.0784 0.5836
SRP159526 MAP2K7 5609 RNAseq 0.0876 0.6274
SRP193095 MAP2K7 5609 RNAseq 0.1752 0.1568
SRP219564 MAP2K7 5609 RNAseq 0.7556 0.1104
TCGA MAP2K7 5609 RNAseq -0.0015 0.9749

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by MAP2K7 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAP2K7:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP2K7 5609 4 3 23
GSE20123 MAP2K7 5609 3 2 25
GSE43470 MAP2K7 5609 2 7 34
GSE46452 MAP2K7 5609 47 1 11
GSE47630 MAP2K7 5609 5 7 28
GSE54993 MAP2K7 5609 16 3 51
GSE54994 MAP2K7 5609 6 14 33
GSE60625 MAP2K7 5609 9 0 2
GSE74703 MAP2K7 5609 2 4 30
GSE74704 MAP2K7 5609 0 2 18
TCGA MAP2K7 5609 9 20 67

Total number of gains: 103; Total number of losses: 63; Total Number of normals: 322.  

 

Somatic mutations of MAP2K7:

 

Generating mutation plots.

 

Highly correlated genes for MAP2K7:

 

Showing top 20/512 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP2K7HAUS20.872958505
MAP2K7GATAD2B0.813484303
MAP2K7MZT2B0.793332605
MAP2K7MYNN0.781769303
MAP2K7QSOX20.774486303
MAP2K7CRTC20.769289403
MAP2K7SURF60.757917404
MAP2K7CPLX10.756443303
MAP2K7TAS2R450.756344303
MAP2K7ZNF2920.754016303
MAP2K7ERN20.7468505
MAP2K7SLC25A190.746022303
MAP2K7PREB0.741976303
MAP2K7NUFIP10.739358303
MAP2K7B3GAT20.73878303
MAP2K7KLHL280.736634403
MAP2K7TMEM2010.728862303
MAP2K7DHDH0.727397303
MAP2K7FOXC10.727116303
MAP2K7ZXDC0.727093404

For details and further investigation, click here