| Full name: endoplasmic reticulum to nucleus signaling 2 | Alias Symbol: IRE1b | ||
| Type: protein-coding gene | Cytoband: 16p12.2 | ||
| Entrez ID: 10595 | HGNC ID: HGNC:16942 | Ensembl Gene: ENSG00000134398 | OMIM ID: 604034 |
| Drug and gene relationship at DGIdb | |||
Expression of ERN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERN2 | 10595 | 214372_x_at | -0.1578 | 0.4006 | |
| GSE20347 | ERN2 | 10595 | 214372_x_at | 0.1685 | 0.1967 | |
| GSE23400 | ERN2 | 10595 | 214372_x_at | -0.0766 | 0.0902 | |
| GSE26886 | ERN2 | 10595 | 214372_x_at | 0.1526 | 0.2027 | |
| GSE29001 | ERN2 | 10595 | 214372_x_at | 0.0686 | 0.6863 | |
| GSE38129 | ERN2 | 10595 | 214372_x_at | -0.0600 | 0.6967 | |
| GSE45670 | ERN2 | 10595 | 214372_x_at | 0.0538 | 0.6260 | |
| GSE63941 | ERN2 | 10595 | 214372_x_at | 0.0089 | 0.9635 | |
| GSE77861 | ERN2 | 10595 | 214372_x_at | 0.1331 | 0.4123 | |
| GSE97050 | ERN2 | 10595 | A_33_P3213645 | 0.6651 | 0.1560 | |
| SRP064894 | ERN2 | 10595 | RNAseq | -0.8107 | 0.0707 | |
| SRP133303 | ERN2 | 10595 | RNAseq | -1.1204 | 0.0026 | |
| SRP159526 | ERN2 | 10595 | RNAseq | -0.6394 | 0.3126 | |
| SRP193095 | ERN2 | 10595 | RNAseq | -0.3468 | 0.5012 | |
| SRP219564 | ERN2 | 10595 | RNAseq | -1.8605 | 0.0190 | |
| TCGA | ERN2 | 10595 | RNAseq | -2.5010 | 0.0004 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ERN2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ERN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERN2 | 10595 | 5 | 4 | 21 | |
| GSE20123 | ERN2 | 10595 | 5 | 3 | 22 | |
| GSE43470 | ERN2 | 10595 | 3 | 3 | 37 | |
| GSE46452 | ERN2 | 10595 | 38 | 1 | 20 | |
| GSE47630 | ERN2 | 10595 | 11 | 6 | 23 | |
| GSE54993 | ERN2 | 10595 | 3 | 5 | 62 | |
| GSE54994 | ERN2 | 10595 | 4 | 8 | 41 | |
| GSE60625 | ERN2 | 10595 | 4 | 0 | 7 | |
| GSE74703 | ERN2 | 10595 | 3 | 2 | 31 | |
| GSE74704 | ERN2 | 10595 | 3 | 1 | 16 | |
| TCGA | ERN2 | 10595 | 19 | 13 | 64 |
Total number of gains: 98; Total number of losses: 46; Total Number of normals: 344.
Somatic mutations of ERN2:
Generating mutation plots.
Highly correlated genes for ERN2:
Showing top 20/354 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERN2 | TAOK1 | 0.760622 | 5 | 0 | 4 |
| ERN2 | CYP1A2 | 0.759766 | 3 | 0 | 3 |
| ERN2 | MAP2K7 | 0.7468 | 5 | 0 | 5 |
| ERN2 | NCKAP1L | 0.742508 | 3 | 0 | 3 |
| ERN2 | HAUS2 | 0.737411 | 8 | 0 | 8 |
| ERN2 | SH2B2 | 0.729764 | 6 | 0 | 6 |
| ERN2 | UBQLN4 | 0.726236 | 6 | 0 | 5 |
| ERN2 | PRKAR2A | 0.721507 | 4 | 0 | 4 |
| ERN2 | PODNL1 | 0.712401 | 8 | 0 | 7 |
| ERN2 | DDX59 | 0.698358 | 4 | 0 | 4 |
| ERN2 | MZT2B | 0.690415 | 8 | 0 | 7 |
| ERN2 | PLCB2 | 0.684279 | 4 | 0 | 3 |
| ERN2 | ZNF721 | 0.683988 | 8 | 0 | 6 |
| ERN2 | MCM3AP | 0.683424 | 3 | 0 | 3 |
| ERN2 | DBT | 0.681474 | 7 | 0 | 6 |
| ERN2 | SNX27 | 0.678193 | 3 | 0 | 3 |
| ERN2 | TMEM214 | 0.677609 | 3 | 0 | 3 |
| ERN2 | ACAP1 | 0.67517 | 3 | 0 | 3 |
| ERN2 | C10orf95 | 0.670882 | 4 | 0 | 4 |
| ERN2 | NCR2 | 0.670385 | 4 | 0 | 4 |
For details and further investigation, click here
