| Full name: forkhead box C1 | Alias Symbol: FREAC3|ARA|IGDA|IHG1 | ||
| Type: protein-coding gene | Cytoband: 6p25.3 | ||
| Entrez ID: 2296 | HGNC ID: HGNC:3800 | Ensembl Gene: ENSG00000054598 | OMIM ID: 601090 |
| Drug and gene relationship at DGIdb | |||
Expression of FOXC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FOXC1 | 2296 | 1553613_s_at | 0.1249 | 0.9436 | |
| GSE20347 | FOXC1 | 2296 | 213260_at | -0.0736 | 0.6249 | |
| GSE23400 | FOXC1 | 2296 | 213260_at | -0.1204 | 0.0541 | |
| GSE26886 | FOXC1 | 2296 | 213260_at | 0.0069 | 0.9814 | |
| GSE29001 | FOXC1 | 2296 | 213260_at | 0.4339 | 0.2532 | |
| GSE38129 | FOXC1 | 2296 | 213260_at | -0.0558 | 0.8186 | |
| GSE45670 | FOXC1 | 2296 | 1553613_s_at | -0.0905 | 0.8626 | |
| GSE53622 | FOXC1 | 2296 | 99614 | 1.3879 | 0.0000 | |
| GSE53624 | FOXC1 | 2296 | 99614 | 1.3681 | 0.0000 | |
| GSE63941 | FOXC1 | 2296 | 1553613_s_at | -0.8535 | 0.4146 | |
| GSE77861 | FOXC1 | 2296 | 213260_at | -0.1878 | 0.4764 | |
| GSE97050 | FOXC1 | 2296 | A_32_P205110 | -0.2795 | 0.3689 | |
| SRP007169 | FOXC1 | 2296 | RNAseq | 0.7891 | 0.3639 | |
| SRP008496 | FOXC1 | 2296 | RNAseq | 0.7940 | 0.1242 | |
| SRP064894 | FOXC1 | 2296 | RNAseq | 0.5161 | 0.1643 | |
| SRP133303 | FOXC1 | 2296 | RNAseq | -0.3381 | 0.3545 | |
| SRP159526 | FOXC1 | 2296 | RNAseq | 0.9749 | 0.1578 | |
| SRP219564 | FOXC1 | 2296 | RNAseq | 0.7057 | 0.1683 | |
| TCGA | FOXC1 | 2296 | RNAseq | 0.2047 | 0.1230 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by FOXC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FOXC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FOXC1 | 2296 | 3 | 6 | 21 | |
| GSE20123 | FOXC1 | 2296 | 3 | 6 | 21 | |
| GSE43470 | FOXC1 | 2296 | 9 | 4 | 30 | |
| GSE46452 | FOXC1 | 2296 | 1 | 10 | 48 | |
| GSE47630 | FOXC1 | 2296 | 7 | 8 | 25 | |
| GSE54993 | FOXC1 | 2296 | 1 | 1 | 68 | |
| GSE54994 | FOXC1 | 2296 | 10 | 3 | 40 | |
| GSE60625 | FOXC1 | 2296 | 0 | 1 | 10 | |
| GSE74703 | FOXC1 | 2296 | 8 | 3 | 25 | |
| GSE74704 | FOXC1 | 2296 | 2 | 3 | 15 | |
| TCGA | FOXC1 | 2296 | 16 | 29 | 51 |
Total number of gains: 60; Total number of losses: 74; Total Number of normals: 354.
Somatic mutations of FOXC1:
Generating mutation plots.
Highly correlated genes for FOXC1:
Showing top 20/223 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FOXC1 | GABBR1 | 0.763569 | 3 | 0 | 3 |
| FOXC1 | MAP2K7 | 0.727116 | 3 | 0 | 3 |
| FOXC1 | USP20 | 0.72698 | 3 | 0 | 3 |
| FOXC1 | FAM131B | 0.717524 | 3 | 0 | 3 |
| FOXC1 | WDTC1 | 0.711179 | 3 | 0 | 3 |
| FOXC1 | BRAT1 | 0.71005 | 3 | 0 | 3 |
| FOXC1 | TP53I11 | 0.707019 | 3 | 0 | 3 |
| FOXC1 | NR4A1 | 0.706401 | 3 | 0 | 3 |
| FOXC1 | FADS1 | 0.705204 | 3 | 0 | 3 |
| FOXC1 | CBX6 | 0.703766 | 3 | 0 | 3 |
| FOXC1 | TRMT5 | 0.700184 | 3 | 0 | 3 |
| FOXC1 | SLC39A3 | 0.694881 | 3 | 0 | 3 |
| FOXC1 | PYCR2 | 0.69405 | 3 | 0 | 3 |
| FOXC1 | LRP3 | 0.692235 | 3 | 0 | 3 |
| FOXC1 | FXYD6 | 0.69158 | 3 | 0 | 3 |
| FOXC1 | RNPS1 | 0.690859 | 4 | 0 | 4 |
| FOXC1 | LMNB2 | 0.690448 | 3 | 0 | 3 |
| FOXC1 | RHBDD2 | 0.689025 | 3 | 0 | 3 |
| FOXC1 | USP42 | 0.688919 | 3 | 0 | 3 |
| FOXC1 | TMEM150A | 0.6883 | 3 | 0 | 3 |
For details and further investigation, click here
