| Full name: kelch like family member 28 | Alias Symbol: FLJ20081 | ||
| Type: protein-coding gene | Cytoband: 14q21.2 | ||
| Entrez ID: 54813 | HGNC ID: HGNC:19741 | Ensembl Gene: ENSG00000179454 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL28:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL28 | 54813 | 235727_at | 0.2101 | 0.6175 | |
| GSE20347 | KLHL28 | 54813 | 220374_at | 0.1449 | 0.4721 | |
| GSE23400 | KLHL28 | 54813 | 220374_at | -0.0518 | 0.2018 | |
| GSE26886 | KLHL28 | 54813 | 235727_at | -0.8505 | 0.0021 | |
| GSE29001 | KLHL28 | 54813 | 220374_at | 0.3027 | 0.1063 | |
| GSE38129 | KLHL28 | 54813 | 220374_at | 0.0642 | 0.7720 | |
| GSE45670 | KLHL28 | 54813 | 228328_at | 0.0674 | 0.7146 | |
| GSE53622 | KLHL28 | 54813 | 25150 | 0.0848 | 0.2870 | |
| GSE53624 | KLHL28 | 54813 | 25150 | -0.0612 | 0.3899 | |
| GSE63941 | KLHL28 | 54813 | 228328_at | -0.5658 | 0.3143 | |
| GSE77861 | KLHL28 | 54813 | 235727_at | 0.2007 | 0.6538 | |
| GSE97050 | KLHL28 | 54813 | A_33_P3304107 | 0.2494 | 0.4921 | |
| SRP007169 | KLHL28 | 54813 | RNAseq | -0.3675 | 0.4285 | |
| SRP008496 | KLHL28 | 54813 | RNAseq | -0.4255 | 0.1244 | |
| SRP064894 | KLHL28 | 54813 | RNAseq | -0.2784 | 0.3510 | |
| SRP133303 | KLHL28 | 54813 | RNAseq | 0.0742 | 0.7440 | |
| SRP159526 | KLHL28 | 54813 | RNAseq | -0.7762 | 0.0004 | |
| SRP193095 | KLHL28 | 54813 | RNAseq | -0.4632 | 0.0003 | |
| SRP219564 | KLHL28 | 54813 | RNAseq | -0.2032 | 0.6743 | |
| TCGA | KLHL28 | 54813 | RNAseq | 0.0430 | 0.4669 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLHL28 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL28:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL28 | 54813 | 6 | 5 | 19 | |
| GSE20123 | KLHL28 | 54813 | 6 | 5 | 19 | |
| GSE43470 | KLHL28 | 54813 | 8 | 3 | 32 | |
| GSE46452 | KLHL28 | 54813 | 17 | 2 | 40 | |
| GSE47630 | KLHL28 | 54813 | 11 | 10 | 19 | |
| GSE54993 | KLHL28 | 54813 | 3 | 9 | 58 | |
| GSE54994 | KLHL28 | 54813 | 18 | 5 | 30 | |
| GSE60625 | KLHL28 | 54813 | 0 | 2 | 9 | |
| GSE74703 | KLHL28 | 54813 | 7 | 3 | 26 | |
| GSE74704 | KLHL28 | 54813 | 3 | 3 | 14 | |
| TCGA | KLHL28 | 54813 | 32 | 15 | 49 |
Total number of gains: 111; Total number of losses: 62; Total Number of normals: 315.
Somatic mutations of KLHL28:
Generating mutation plots.
Highly correlated genes for KLHL28:
Showing top 20/243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL28 | TDP1 | 0.88985 | 3 | 0 | 3 |
| KLHL28 | IL17RD | 0.792006 | 3 | 0 | 3 |
| KLHL28 | ZNF577 | 0.768417 | 3 | 0 | 3 |
| KLHL28 | ERGIC1 | 0.753682 | 3 | 0 | 3 |
| KLHL28 | G2E3 | 0.75048 | 3 | 0 | 3 |
| KLHL28 | HAUS2 | 0.741085 | 6 | 0 | 6 |
| KLHL28 | MAP2K7 | 0.736634 | 4 | 0 | 3 |
| KLHL28 | NAA25 | 0.732451 | 3 | 0 | 3 |
| KLHL28 | RALGPS2 | 0.731206 | 4 | 0 | 4 |
| KLHL28 | TNFSF14 | 0.730338 | 3 | 0 | 3 |
| KLHL28 | ZC3H7B | 0.725937 | 4 | 0 | 4 |
| KLHL28 | MTF1 | 0.722473 | 3 | 0 | 3 |
| KLHL28 | ALMS1 | 0.716809 | 5 | 0 | 5 |
| KLHL28 | PPP2R3A | 0.715924 | 3 | 0 | 3 |
| KLHL28 | NUBPL | 0.710683 | 4 | 0 | 4 |
| KLHL28 | FAM126B | 0.709302 | 3 | 0 | 3 |
| KLHL28 | SLC35E1 | 0.709287 | 7 | 0 | 6 |
| KLHL28 | USF1 | 0.708517 | 3 | 0 | 3 |
| KLHL28 | IPMK | 0.706799 | 3 | 0 | 3 |
| KLHL28 | HDAC3 | 0.69518 | 3 | 0 | 3 |
For details and further investigation, click here
