| Full name: dihydrodiol dehydrogenase | Alias Symbol: HUM2DD | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 27294 | HGNC ID: HGNC:17887 | Ensembl Gene: ENSG00000104808 | OMIM ID: 606377 |
| Drug and gene relationship at DGIdb | |||
Expression of DHDH:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHDH | 27294 | 231416_at | 0.0980 | 0.7296 | |
| GSE26886 | DHDH | 27294 | 231416_at | -0.1774 | 0.2339 | |
| GSE45670 | DHDH | 27294 | 231416_at | 0.2922 | 0.3509 | |
| GSE53622 | DHDH | 27294 | 127772 | 0.2705 | 0.0025 | |
| GSE53624 | DHDH | 27294 | 127772 | 0.2767 | 0.0045 | |
| GSE63941 | DHDH | 27294 | 231416_at | 0.5523 | 0.0482 | |
| GSE77861 | DHDH | 27294 | 231416_at | -0.1396 | 0.3459 | |
| GSE97050 | DHDH | 27294 | A_23_P67367 | 0.0312 | 0.8830 | |
| SRP219564 | DHDH | 27294 | RNAseq | -0.9156 | 0.0837 | |
| TCGA | DHDH | 27294 | RNAseq | 0.6673 | 0.1382 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DHDH expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHDH:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHDH | 27294 | 4 | 4 | 22 | |
| GSE20123 | DHDH | 27294 | 4 | 3 | 23 | |
| GSE43470 | DHDH | 27294 | 4 | 10 | 29 | |
| GSE46452 | DHDH | 27294 | 45 | 1 | 13 | |
| GSE47630 | DHDH | 27294 | 9 | 6 | 25 | |
| GSE54993 | DHDH | 27294 | 17 | 4 | 49 | |
| GSE54994 | DHDH | 27294 | 4 | 14 | 35 | |
| GSE60625 | DHDH | 27294 | 9 | 0 | 2 | |
| GSE74703 | DHDH | 27294 | 4 | 7 | 25 | |
| GSE74704 | DHDH | 27294 | 4 | 1 | 15 | |
| TCGA | DHDH | 27294 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of DHDH:
Generating mutation plots.
Highly correlated genes for DHDH:
Showing top 20/91 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHDH | GDF11 | 0.823755 | 3 | 0 | 3 |
| DHDH | SLC13A2 | 0.811232 | 3 | 0 | 3 |
| DHDH | MAST2 | 0.780496 | 3 | 0 | 3 |
| DHDH | FHL3 | 0.749578 | 3 | 0 | 3 |
| DHDH | JPH2 | 0.732933 | 3 | 0 | 3 |
| DHDH | MAP2K7 | 0.727397 | 3 | 0 | 3 |
| DHDH | PPP2R1A | 0.720374 | 3 | 0 | 3 |
| DHDH | PPP2R5C | 0.709434 | 4 | 0 | 4 |
| DHDH | KLHDC3 | 0.703497 | 3 | 0 | 3 |
| DHDH | PLEKHA4 | 0.703302 | 3 | 0 | 3 |
| DHDH | AP2M1 | 0.698196 | 3 | 0 | 3 |
| DHDH | HCFC1 | 0.698183 | 3 | 0 | 3 |
| DHDH | TNFSF14 | 0.698002 | 3 | 0 | 3 |
| DHDH | BSG | 0.697268 | 3 | 0 | 3 |
| DHDH | SPEN | 0.695842 | 3 | 0 | 3 |
| DHDH | DNAH11 | 0.694596 | 3 | 0 | 3 |
| DHDH | NUCB1 | 0.687719 | 4 | 0 | 4 |
| DHDH | SLC29A1 | 0.686884 | 4 | 0 | 4 |
| DHDH | LSM11 | 0.685211 | 3 | 0 | 3 |
| DHDH | VWA1 | 0.684519 | 3 | 0 | 3 |
For details and further investigation, click here
