| Full name: prolactin regulatory element binding | Alias Symbol: SEC12 | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 10113 | HGNC ID: HGNC:9356 | Ensembl Gene: ENSG00000138073 | OMIM ID: 606395 |
| Drug and gene relationship at DGIdb | |||
Expression of PREB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PREB | 10113 | 217861_s_at | 0.6504 | 0.0269 | |
| GSE20347 | PREB | 10113 | 217861_s_at | 0.4027 | 0.0068 | |
| GSE23400 | PREB | 10113 | 217861_s_at | 0.2207 | 0.0000 | |
| GSE26886 | PREB | 10113 | 217861_s_at | -0.2139 | 0.0438 | |
| GSE29001 | PREB | 10113 | 217861_s_at | 0.2635 | 0.0693 | |
| GSE38129 | PREB | 10113 | 217861_s_at | 0.4628 | 0.0000 | |
| GSE45670 | PREB | 10113 | 217861_s_at | 0.5937 | 0.0000 | |
| GSE53622 | PREB | 10113 | 41765 | 0.5324 | 0.0000 | |
| GSE53624 | PREB | 10113 | 91567 | 0.4846 | 0.0000 | |
| GSE63941 | PREB | 10113 | 217861_s_at | -0.0775 | 0.8783 | |
| GSE77861 | PREB | 10113 | 217861_s_at | 0.1632 | 0.3408 | |
| GSE97050 | PREB | 10113 | A_23_P91114 | 0.5703 | 0.1372 | |
| SRP007169 | PREB | 10113 | RNAseq | 0.3982 | 0.2214 | |
| SRP008496 | PREB | 10113 | RNAseq | 0.2788 | 0.2176 | |
| SRP064894 | PREB | 10113 | RNAseq | 0.6792 | 0.0005 | |
| SRP133303 | PREB | 10113 | RNAseq | 0.5074 | 0.0003 | |
| SRP159526 | PREB | 10113 | RNAseq | 0.4906 | 0.0262 | |
| SRP193095 | PREB | 10113 | RNAseq | 0.1901 | 0.1067 | |
| SRP219564 | PREB | 10113 | RNAseq | 0.3934 | 0.1718 | |
| TCGA | PREB | 10113 | RNAseq | -0.0193 | 0.7034 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PREB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PREB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PREB | 10113 | 11 | 2 | 17 | |
| GSE20123 | PREB | 10113 | 11 | 2 | 17 | |
| GSE43470 | PREB | 10113 | 3 | 1 | 39 | |
| GSE46452 | PREB | 10113 | 3 | 4 | 52 | |
| GSE47630 | PREB | 10113 | 8 | 0 | 32 | |
| GSE54993 | PREB | 10113 | 0 | 6 | 64 | |
| GSE54994 | PREB | 10113 | 10 | 0 | 43 | |
| GSE60625 | PREB | 10113 | 0 | 3 | 8 | |
| GSE74703 | PREB | 10113 | 3 | 0 | 33 | |
| GSE74704 | PREB | 10113 | 9 | 1 | 10 | |
| TCGA | PREB | 10113 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of PREB:
Generating mutation plots.
Highly correlated genes for PREB:
Showing top 20/1061 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PREB | NF2 | 0.775401 | 3 | 0 | 3 |
| PREB | DGKQ | 0.770518 | 3 | 0 | 3 |
| PREB | PRELID1 | 0.76562 | 3 | 0 | 3 |
| PREB | ORAI1 | 0.755358 | 4 | 0 | 3 |
| PREB | FAM90A1 | 0.752386 | 3 | 0 | 3 |
| PREB | ILVBL | 0.747151 | 3 | 0 | 3 |
| PREB | P2RY6 | 0.745577 | 3 | 0 | 3 |
| PREB | MAP2K7 | 0.741976 | 3 | 0 | 3 |
| PREB | TBCD | 0.741497 | 3 | 0 | 3 |
| PREB | SLC39A3 | 0.728392 | 3 | 0 | 3 |
| PREB | SLC25A39 | 0.727453 | 3 | 0 | 3 |
| PREB | CWF19L1 | 0.727273 | 4 | 0 | 4 |
| PREB | C1orf131 | 0.726872 | 5 | 0 | 5 |
| PREB | DNAJB11 | 0.724795 | 5 | 0 | 5 |
| PREB | C12orf73 | 0.72254 | 3 | 0 | 3 |
| PREB | UHMK1 | 0.721825 | 4 | 0 | 3 |
| PREB | C6orf62 | 0.721571 | 3 | 0 | 3 |
| PREB | LRRC58 | 0.715895 | 4 | 0 | 3 |
| PREB | CERS5 | 0.7154 | 3 | 0 | 3 |
| PREB | SAMD1 | 0.714234 | 5 | 0 | 5 |
For details and further investigation, click here
