CRTC2

 

Full name: CREB regulated transcription coactivator 2 Alias Symbol: TORC2
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 200186 HGNC ID: HGNC:27301 Ensembl Gene: ENSG00000160741 OMIM ID: 608972
Drug and gene relationship at DGIdb

 

CRTC2 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance
hsa05166HTLV-I infection

 

Expression of CRTC2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CRTC2 200186 226307_at 0.5396 0.1908
GSE26886 CRTC2 200186 226307_at 0.7764 0.0000
GSE45670 CRTC2 200186 226307_at 0.0899 0.3736
GSE53622 CRTC2 200186 113323 0.0059 0.9342
GSE53624 CRTC2 200186 113323 0.3370 0.0000
GSE63941 CRTC2 200186 226307_at -0.2113 0.3547
GSE77861 CRTC2 200186 226307_at 0.4326 0.0086
GSE97050 CRTC2 200186 A_23_P12173 0.0695 0.7484
SRP007169 CRTC2 200186 RNAseq -0.4882 0.2394
SRP008496 CRTC2 200186 RNAseq 0.0124 0.9616
SRP064894 CRTC2 200186 RNAseq 0.1892 0.1523
SRP133303 CRTC2 200186 RNAseq 0.0792 0.5584
SRP159526 CRTC2 200186 RNAseq 0.4261 0.1266
SRP193095 CRTC2 200186 RNAseq 0.4254 0.0010
SRP219564 CRTC2 200186 RNAseq 0.3617 0.3088
TCGA CRTC2 200186 RNAseq 0.1169 0.0193

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CRTC2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CRTC2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CRTC2 200186 14 0 16
GSE20123 CRTC2 200186 14 0 16
GSE43470 CRTC2 200186 7 2 34
GSE46452 CRTC2 200186 2 1 56
GSE47630 CRTC2 200186 14 0 26
GSE54993 CRTC2 200186 0 4 66
GSE54994 CRTC2 200186 16 0 37
GSE60625 CRTC2 200186 0 0 11
GSE74703 CRTC2 200186 6 1 29
GSE74704 CRTC2 200186 7 0 13
TCGA CRTC2 200186 38 2 56

Total number of gains: 118; Total number of losses: 10; Total Number of normals: 360.  

 

Somatic mutations of CRTC2:

 

Generating mutation plots.

 

Highly correlated genes for CRTC2:

 

Showing top 20/1192 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CRTC2SF10.854246303
CRTC2DDX110.846108303
CRTC2MEA10.84188303
CRTC2SEMA3C0.838146303
CRTC2EHMT20.8356303
CRTC2DARS20.828484303
CRTC2PARVB0.824652303
CRTC2CELF10.82367303
CRTC2UTP230.821947303
CRTC2PA2G40.821943303
CRTC2MADD0.816934303
CRTC2YLPM10.814322303
CRTC2RAB150.81164404
CRTC2UXS10.811196303
CRTC2PRPS10.809712303
CRTC2NR1H30.808308303
CRTC2FCHO10.808281303
CRTC2RPL7L10.807232303
CRTC2TEX100.806694303
CRTC2FANCL0.806678303

For details and further investigation, click here