| Full name: mitogen-activated protein kinase kinase kinase 11 | Alias Symbol: SPRK|MEKK11 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 4296 | HGNC ID: HGNC:6850 | Ensembl Gene: ENSG00000173327 | OMIM ID: 600050 |
| Drug and gene relationship at DGIdb | |||
MAP3K11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD) |
Expression of MAP3K11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP3K11 | 4296 | 203652_at | 0.6195 | 0.0534 | |
| GSE20347 | MAP3K11 | 4296 | 203652_at | 0.4607 | 0.0012 | |
| GSE23400 | MAP3K11 | 4296 | 203652_at | 0.2881 | 0.0000 | |
| GSE26886 | MAP3K11 | 4296 | 203652_at | 1.1359 | 0.0000 | |
| GSE29001 | MAP3K11 | 4296 | 203652_at | 0.3247 | 0.1583 | |
| GSE38129 | MAP3K11 | 4296 | 203652_at | 0.2563 | 0.0420 | |
| GSE45670 | MAP3K11 | 4296 | 203652_at | 0.3906 | 0.0005 | |
| GSE53622 | MAP3K11 | 4296 | 81114 | 0.2909 | 0.0001 | |
| GSE53624 | MAP3K11 | 4296 | 81114 | 0.7161 | 0.0000 | |
| GSE63941 | MAP3K11 | 4296 | 203652_at | 0.8932 | 0.0184 | |
| GSE77861 | MAP3K11 | 4296 | 203652_at | 0.6078 | 0.0129 | |
| GSE97050 | MAP3K11 | 4296 | A_33_P3301851 | 0.5058 | 0.1855 | |
| SRP007169 | MAP3K11 | 4296 | RNAseq | -0.0898 | 0.7941 | |
| SRP008496 | MAP3K11 | 4296 | RNAseq | -0.1127 | 0.6429 | |
| SRP064894 | MAP3K11 | 4296 | RNAseq | 0.5408 | 0.0153 | |
| SRP133303 | MAP3K11 | 4296 | RNAseq | 0.3026 | 0.1592 | |
| SRP159526 | MAP3K11 | 4296 | RNAseq | 0.2448 | 0.3487 | |
| SRP193095 | MAP3K11 | 4296 | RNAseq | 0.2935 | 0.0252 | |
| SRP219564 | MAP3K11 | 4296 | RNAseq | 0.0949 | 0.7655 | |
| TCGA | MAP3K11 | 4296 | RNAseq | 0.0504 | 0.2523 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MAP3K11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP3K11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP3K11 | 4296 | 8 | 5 | 17 | |
| GSE20123 | MAP3K11 | 4296 | 8 | 5 | 17 | |
| GSE43470 | MAP3K11 | 4296 | 4 | 1 | 38 | |
| GSE46452 | MAP3K11 | 4296 | 11 | 3 | 45 | |
| GSE47630 | MAP3K11 | 4296 | 7 | 5 | 28 | |
| GSE54993 | MAP3K11 | 4296 | 3 | 0 | 67 | |
| GSE54994 | MAP3K11 | 4296 | 7 | 5 | 41 | |
| GSE60625 | MAP3K11 | 4296 | 0 | 3 | 8 | |
| GSE74703 | MAP3K11 | 4296 | 3 | 0 | 33 | |
| GSE74704 | MAP3K11 | 4296 | 6 | 3 | 11 | |
| TCGA | MAP3K11 | 4296 | 23 | 7 | 66 |
Total number of gains: 80; Total number of losses: 37; Total Number of normals: 371.
Somatic mutations of MAP3K11:
Generating mutation plots.
Highly correlated genes for MAP3K11:
Showing top 20/1498 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP3K11 | GNB5 | 0.818535 | 3 | 0 | 3 |
| MAP3K11 | ZNF358 | 0.786673 | 3 | 0 | 3 |
| MAP3K11 | MSTO1 | 0.783536 | 5 | 0 | 5 |
| MAP3K11 | NUP43 | 0.780192 | 5 | 0 | 5 |
| MAP3K11 | ACBD6 | 0.768669 | 4 | 0 | 4 |
| MAP3K11 | KRTCAP2 | 0.764122 | 4 | 0 | 4 |
| MAP3K11 | ARHGEF11 | 0.761713 | 3 | 0 | 3 |
| MAP3K11 | CENPV | 0.759166 | 3 | 0 | 3 |
| MAP3K11 | GEN1 | 0.758072 | 4 | 0 | 3 |
| MAP3K11 | RILPL2 | 0.746283 | 3 | 0 | 3 |
| MAP3K11 | DGCR8 | 0.746197 | 3 | 0 | 3 |
| MAP3K11 | XXYLT1 | 0.745514 | 4 | 0 | 4 |
| MAP3K11 | SLC39A3 | 0.74541 | 4 | 0 | 4 |
| MAP3K11 | ARV1 | 0.745261 | 3 | 0 | 3 |
| MAP3K11 | PIK3R3 | 0.744913 | 3 | 0 | 3 |
| MAP3K11 | CDC42EP4 | 0.732695 | 3 | 0 | 3 |
| MAP3K11 | TP53I13 | 0.724231 | 6 | 0 | 5 |
| MAP3K11 | DDX60L | 0.721858 | 3 | 0 | 3 |
| MAP3K11 | TMTC4 | 0.721289 | 3 | 0 | 3 |
| MAP3K11 | COLEC11 | 0.720875 | 3 | 0 | 3 |
For details and further investigation, click here
