| Full name: Rho guanine nucleotide exchange factor 11 | Alias Symbol: KIAA0380|GTRAP48|PDZ-RHOGEF | ||
| Type: protein-coding gene | Cytoband: 1q23.1 | ||
| Entrez ID: 9826 | HGNC ID: HGNC:14580 | Ensembl Gene: ENSG00000132694 | OMIM ID: 605708 |
| Drug and gene relationship at DGIdb | |||
ARHGEF11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04270 | Vascular smooth muscle contraction |
Expression of ARHGEF11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARHGEF11 | 9826 | 202913_at | 0.5347 | 0.0528 | |
| GSE20347 | ARHGEF11 | 9826 | 202913_at | 0.0659 | 0.3871 | |
| GSE23400 | ARHGEF11 | 9826 | 202913_at | -0.0145 | 0.6998 | |
| GSE26886 | ARHGEF11 | 9826 | 202913_at | -0.0099 | 0.9617 | |
| GSE29001 | ARHGEF11 | 9826 | 202913_at | -0.0079 | 0.9778 | |
| GSE38129 | ARHGEF11 | 9826 | 202913_at | 0.0809 | 0.2824 | |
| GSE45670 | ARHGEF11 | 9826 | 202913_at | 0.0600 | 0.5917 | |
| GSE53622 | ARHGEF11 | 9826 | 121117 | 0.0803 | 0.2941 | |
| GSE53624 | ARHGEF11 | 9826 | 121117 | 0.1226 | 0.0504 | |
| GSE63941 | ARHGEF11 | 9826 | 202913_at | 0.3136 | 0.1782 | |
| GSE77861 | ARHGEF11 | 9826 | 202913_at | 0.1216 | 0.5949 | |
| GSE97050 | ARHGEF11 | 9826 | A_23_P426809 | 0.0468 | 0.8307 | |
| SRP007169 | ARHGEF11 | 9826 | RNAseq | -0.7116 | 0.0947 | |
| SRP008496 | ARHGEF11 | 9826 | RNAseq | -0.3939 | 0.1217 | |
| SRP064894 | ARHGEF11 | 9826 | RNAseq | -0.1583 | 0.3886 | |
| SRP133303 | ARHGEF11 | 9826 | RNAseq | 0.1067 | 0.4552 | |
| SRP159526 | ARHGEF11 | 9826 | RNAseq | 1.0873 | 0.0113 | |
| SRP193095 | ARHGEF11 | 9826 | RNAseq | 0.0624 | 0.5643 | |
| SRP219564 | ARHGEF11 | 9826 | RNAseq | 0.1837 | 0.4810 | |
| TCGA | ARHGEF11 | 9826 | RNAseq | -0.0983 | 0.0230 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ARHGEF11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARHGEF11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARHGEF11 | 9826 | 12 | 0 | 18 | |
| GSE20123 | ARHGEF11 | 9826 | 12 | 0 | 18 | |
| GSE43470 | ARHGEF11 | 9826 | 7 | 2 | 34 | |
| GSE46452 | ARHGEF11 | 9826 | 2 | 1 | 56 | |
| GSE47630 | ARHGEF11 | 9826 | 14 | 0 | 26 | |
| GSE54993 | ARHGEF11 | 9826 | 0 | 5 | 65 | |
| GSE54994 | ARHGEF11 | 9826 | 16 | 0 | 37 | |
| GSE60625 | ARHGEF11 | 9826 | 0 | 0 | 11 | |
| GSE74703 | ARHGEF11 | 9826 | 7 | 2 | 27 | |
| GSE74704 | ARHGEF11 | 9826 | 6 | 0 | 14 | |
| TCGA | ARHGEF11 | 9826 | 38 | 3 | 55 |
Total number of gains: 114; Total number of losses: 13; Total Number of normals: 361.
Somatic mutations of ARHGEF11:
Generating mutation plots.
Highly correlated genes for ARHGEF11:
Showing top 20/285 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARHGEF11 | FLVCR1 | 0.791711 | 3 | 0 | 3 |
| ARHGEF11 | IFFO2 | 0.787148 | 3 | 0 | 3 |
| ARHGEF11 | RAB7A | 0.786513 | 3 | 0 | 3 |
| ARHGEF11 | C1orf131 | 0.784174 | 3 | 0 | 3 |
| ARHGEF11 | ZGPAT | 0.782018 | 3 | 0 | 3 |
| ARHGEF11 | GRWD1 | 0.775123 | 3 | 0 | 3 |
| ARHGEF11 | KDM1B | 0.765564 | 3 | 0 | 3 |
| ARHGEF11 | MAP3K11 | 0.761713 | 3 | 0 | 3 |
| ARHGEF11 | KRI1 | 0.758048 | 3 | 0 | 3 |
| ARHGEF11 | PACS1 | 0.75596 | 3 | 0 | 3 |
| ARHGEF11 | VAPB | 0.755149 | 3 | 0 | 3 |
| ARHGEF11 | HMBOX1 | 0.751748 | 3 | 0 | 3 |
| ARHGEF11 | MIER2 | 0.746423 | 4 | 0 | 4 |
| ARHGEF11 | DGCR2 | 0.746048 | 3 | 0 | 3 |
| ARHGEF11 | MMP15 | 0.743199 | 3 | 0 | 3 |
| ARHGEF11 | NTPCR | 0.73862 | 3 | 0 | 3 |
| ARHGEF11 | FAM89B | 0.737467 | 4 | 0 | 3 |
| ARHGEF11 | SNTA1 | 0.734843 | 3 | 0 | 3 |
| ARHGEF11 | TMEM184B | 0.73459 | 3 | 0 | 3 |
| ARHGEF11 | FZR1 | 0.732429 | 4 | 0 | 3 |
For details and further investigation, click here
