GNB5

 

Full name: G protein subunit beta 5 Alias Symbol: GB5
Type: protein-coding gene Cytoband: 15q21.2
Entrez ID: 10681 HGNC ID: HGNC:4401 Ensembl Gene: ENSG00000069966 OMIM ID: 604447
Drug and gene relationship at DGIdb

 

GNB5 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNB5:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNB5 10681 204000_at -0.1565 0.8657
GSE20347 GNB5 10681 204000_at 0.4234 0.0024
GSE23400 GNB5 10681 204000_at 0.0835 0.2400
GSE26886 GNB5 10681 204000_at 1.4053 0.0000
GSE29001 GNB5 10681 204000_at 0.5057 0.0744
GSE38129 GNB5 10681 204000_at 0.3324 0.0768
GSE45670 GNB5 10681 204000_at 0.1928 0.3473
GSE53622 GNB5 10681 46274 0.8042 0.0000
GSE53624 GNB5 10681 46274 0.7848 0.0000
GSE63941 GNB5 10681 204000_at -0.1339 0.8128
GSE77861 GNB5 10681 204000_at 0.7283 0.0013
GSE97050 GNB5 10681 A_23_P205778 -0.0154 0.9611
SRP007169 GNB5 10681 RNAseq 0.4684 0.2571
SRP008496 GNB5 10681 RNAseq 0.5721 0.0365
SRP064894 GNB5 10681 RNAseq 0.6802 0.0000
SRP133303 GNB5 10681 RNAseq 0.6166 0.0000
SRP159526 GNB5 10681 RNAseq 0.5627 0.1937
SRP193095 GNB5 10681 RNAseq 0.8415 0.0000
SRP219564 GNB5 10681 RNAseq 0.1508 0.7436
TCGA GNB5 10681 RNAseq 0.0534 0.3974

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by GNB5 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNB5:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNB5 10681 5 4 21
GSE20123 GNB5 10681 5 4 21
GSE43470 GNB5 10681 4 3 36
GSE46452 GNB5 10681 3 7 49
GSE47630 GNB5 10681 8 10 22
GSE54993 GNB5 10681 5 6 59
GSE54994 GNB5 10681 5 7 41
GSE60625 GNB5 10681 4 0 7
GSE74703 GNB5 10681 4 2 30
GSE74704 GNB5 10681 2 3 15
TCGA GNB5 10681 9 17 70

Total number of gains: 54; Total number of losses: 63; Total Number of normals: 371.  

 

Somatic mutations of GNB5:

 

Generating mutation plots.

 

Highly correlated genes for GNB5:

 

Showing top 20/1258 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNB5PPP1R350.831625303
GNB5PET1170.831314303
GNB5MAP3K110.818535303
GNB5SH2B20.795877303
GNB5SGTB0.787189404
GNB5PSMG30.778835303
GNB5RELL10.774903303
GNB5AKAP80.769415303
GNB5GSR0.768428303
GNB5ALKBH60.755204403
GNB5IRF2BP20.753667303
GNB5TMTC10.753066404
GNB5LRCH30.747677505
GNB5ZCRB10.743873303
GNB5DOCK110.742791404
GNB5SFT2D30.738556303
GNB5TRMT60.734325403
GNB5PDE6D0.734246403
GNB5C1orf1980.733792303
GNB5SDR39U10.733726303

For details and further investigation, click here