| Full name: transmembrane O-mannosyltransferase targeting cadherins 4 | Alias Symbol: FLJ14624|FLJ22153 | ||
| Type: protein-coding gene | Cytoband: 13q32.3 | ||
| Entrez ID: 84899 | HGNC ID: HGNC:25904 | Ensembl Gene: ENSG00000125247 | OMIM ID: 618203 |
| Drug and gene relationship at DGIdb | |||
Expression of TMTC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMTC4 | 84899 | 225666_at | 1.1221 | 0.1633 | |
| GSE26886 | TMTC4 | 84899 | 225666_at | 0.7205 | 0.1121 | |
| GSE45670 | TMTC4 | 84899 | 225666_at | 0.1994 | 0.5700 | |
| GSE53622 | TMTC4 | 84899 | 52663 | 0.2103 | 0.0631 | |
| GSE53624 | TMTC4 | 84899 | 52663 | 0.1909 | 0.0776 | |
| GSE63941 | TMTC4 | 84899 | 225666_at | -1.0330 | 0.1718 | |
| GSE77861 | TMTC4 | 84899 | 225666_at | 0.7889 | 0.0493 | |
| GSE97050 | TMTC4 | 84899 | A_23_P65230 | 0.2345 | 0.3967 | |
| SRP007169 | TMTC4 | 84899 | RNAseq | 1.5378 | 0.0164 | |
| SRP008496 | TMTC4 | 84899 | RNAseq | 1.9593 | 0.0004 | |
| SRP064894 | TMTC4 | 84899 | RNAseq | 0.4162 | 0.0281 | |
| SRP133303 | TMTC4 | 84899 | RNAseq | 0.3303 | 0.1680 | |
| SRP159526 | TMTC4 | 84899 | RNAseq | 0.2508 | 0.3465 | |
| SRP193095 | TMTC4 | 84899 | RNAseq | -0.0494 | 0.7182 | |
| SRP219564 | TMTC4 | 84899 | RNAseq | 0.3995 | 0.4777 | |
| TCGA | TMTC4 | 84899 | RNAseq | -0.2112 | 0.0166 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TMTC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMTC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMTC4 | 84899 | 3 | 9 | 18 | |
| GSE20123 | TMTC4 | 84899 | 3 | 8 | 19 | |
| GSE43470 | TMTC4 | 84899 | 4 | 12 | 27 | |
| GSE46452 | TMTC4 | 84899 | 0 | 32 | 27 | |
| GSE47630 | TMTC4 | 84899 | 3 | 26 | 11 | |
| GSE54993 | TMTC4 | 84899 | 11 | 4 | 55 | |
| GSE54994 | TMTC4 | 84899 | 6 | 10 | 37 | |
| GSE60625 | TMTC4 | 84899 | 0 | 3 | 8 | |
| GSE74703 | TMTC4 | 84899 | 3 | 10 | 23 | |
| GSE74704 | TMTC4 | 84899 | 1 | 8 | 11 | |
| TCGA | TMTC4 | 84899 | 17 | 34 | 45 |
Total number of gains: 51; Total number of losses: 156; Total Number of normals: 281.
Somatic mutations of TMTC4:
Generating mutation plots.
Highly correlated genes for TMTC4:
Showing top 20/833 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMTC4 | ZFYVE27 | 0.895654 | 3 | 0 | 3 |
| TMTC4 | RBM4B | 0.849965 | 3 | 0 | 3 |
| TMTC4 | CBLB | 0.824945 | 3 | 0 | 3 |
| TMTC4 | CXCL16 | 0.814806 | 3 | 0 | 3 |
| TMTC4 | ADAR | 0.810784 | 3 | 0 | 3 |
| TMTC4 | NSUN5 | 0.810558 | 3 | 0 | 3 |
| TMTC4 | ZNF451 | 0.806067 | 3 | 0 | 3 |
| TMTC4 | KDM1B | 0.802759 | 3 | 0 | 3 |
| TMTC4 | CDCA3 | 0.802335 | 3 | 0 | 3 |
| TMTC4 | GTPBP6 | 0.801956 | 3 | 0 | 3 |
| TMTC4 | ITGAE | 0.798943 | 3 | 0 | 3 |
| TMTC4 | U2AF2 | 0.79398 | 3 | 0 | 3 |
| TMTC4 | CRTC2 | 0.791722 | 3 | 0 | 3 |
| TMTC4 | MAPKAPK2 | 0.790654 | 3 | 0 | 3 |
| TMTC4 | STAT2 | 0.787888 | 3 | 0 | 3 |
| TMTC4 | IGF2R | 0.786506 | 3 | 0 | 3 |
| TMTC4 | FZD6 | 0.784218 | 4 | 0 | 4 |
| TMTC4 | SENP3 | 0.779432 | 3 | 0 | 3 |
| TMTC4 | TRAF3 | 0.775307 | 3 | 0 | 3 |
| TMTC4 | PDCD2L | 0.773844 | 4 | 0 | 3 |
For details and further investigation, click here
