| Full name: mitogen-activated protein kinase 8 interacting protein 1 | Alias Symbol: IB1|JIP-1|JIP1 | ||
| Type: protein-coding gene | Cytoband: 11p11.2 | ||
| Entrez ID: 9479 | HGNC ID: HGNC:6882 | Ensembl Gene: ENSG00000121653 | OMIM ID: 604641 |
| Drug and gene relationship at DGIdb | |||
MAPK8IP1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of MAPK8IP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPK8IP1 | 9479 | 213014_at | -0.2749 | 0.1789 | |
| GSE20347 | MAPK8IP1 | 9479 | 213014_at | -0.1856 | 0.0020 | |
| GSE23400 | MAPK8IP1 | 9479 | 213014_at | -0.2437 | 0.0000 | |
| GSE26886 | MAPK8IP1 | 9479 | 213014_at | -0.0635 | 0.7341 | |
| GSE29001 | MAPK8IP1 | 9479 | 213014_at | -0.2109 | 0.0845 | |
| GSE38129 | MAPK8IP1 | 9479 | 213014_at | -0.2155 | 0.0000 | |
| GSE45670 | MAPK8IP1 | 9479 | 213014_at | -0.0550 | 0.6511 | |
| GSE53622 | MAPK8IP1 | 9479 | 156091 | 0.2671 | 0.0025 | |
| GSE53624 | MAPK8IP1 | 9479 | 156091 | -0.0140 | 0.8801 | |
| GSE63941 | MAPK8IP1 | 9479 | 213014_at | 0.4909 | 0.0821 | |
| GSE77861 | MAPK8IP1 | 9479 | 213014_at | -0.1776 | 0.0864 | |
| GSE97050 | MAPK8IP1 | 9479 | A_24_P409595 | 0.0496 | 0.8312 | |
| SRP007169 | MAPK8IP1 | 9479 | RNAseq | 1.5745 | 0.0276 | |
| SRP008496 | MAPK8IP1 | 9479 | RNAseq | 1.7003 | 0.0004 | |
| SRP064894 | MAPK8IP1 | 9479 | RNAseq | 0.9456 | 0.0245 | |
| SRP133303 | MAPK8IP1 | 9479 | RNAseq | 0.4149 | 0.2401 | |
| SRP159526 | MAPK8IP1 | 9479 | RNAseq | 1.1507 | 0.0006 | |
| SRP193095 | MAPK8IP1 | 9479 | RNAseq | 0.9953 | 0.0001 | |
| SRP219564 | MAPK8IP1 | 9479 | RNAseq | 0.1616 | 0.8547 | |
| TCGA | MAPK8IP1 | 9479 | RNAseq | -0.4804 | 0.0016 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by MAPK8IP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPK8IP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPK8IP1 | 9479 | 3 | 7 | 20 | |
| GSE20123 | MAPK8IP1 | 9479 | 2 | 6 | 22 | |
| GSE43470 | MAPK8IP1 | 9479 | 2 | 4 | 37 | |
| GSE46452 | MAPK8IP1 | 9479 | 8 | 5 | 46 | |
| GSE47630 | MAPK8IP1 | 9479 | 3 | 9 | 28 | |
| GSE54993 | MAPK8IP1 | 9479 | 3 | 0 | 67 | |
| GSE54994 | MAPK8IP1 | 9479 | 2 | 10 | 41 | |
| GSE60625 | MAPK8IP1 | 9479 | 0 | 0 | 11 | |
| GSE74703 | MAPK8IP1 | 9479 | 2 | 2 | 32 | |
| GSE74704 | MAPK8IP1 | 9479 | 1 | 4 | 15 | |
| TCGA | MAPK8IP1 | 9479 | 16 | 18 | 62 |
Total number of gains: 42; Total number of losses: 65; Total Number of normals: 381.
Somatic mutations of MAPK8IP1:
Generating mutation plots.
Highly correlated genes for MAPK8IP1:
Showing top 20/672 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPK8IP1 | FAM110B | 0.832617 | 3 | 0 | 3 |
| MAPK8IP1 | LTC4S | 0.736561 | 3 | 0 | 3 |
| MAPK8IP1 | ANKDD1A | 0.682042 | 4 | 0 | 4 |
| MAPK8IP1 | C4BPB | 0.681575 | 4 | 0 | 3 |
| MAPK8IP1 | PSG7 | 0.679251 | 3 | 0 | 3 |
| MAPK8IP1 | ARX | 0.677839 | 3 | 0 | 3 |
| MAPK8IP1 | GNMT | 0.674185 | 3 | 0 | 3 |
| MAPK8IP1 | MASP2 | 0.671836 | 6 | 0 | 6 |
| MAPK8IP1 | MYL4 | 0.671625 | 7 | 0 | 6 |
| MAPK8IP1 | IQCF3 | 0.667184 | 3 | 0 | 3 |
| MAPK8IP1 | OR2T1 | 0.666153 | 3 | 0 | 3 |
| MAPK8IP1 | POU4F3 | 0.664753 | 4 | 0 | 4 |
| MAPK8IP1 | DNAH10OS | 0.661495 | 3 | 0 | 3 |
| MAPK8IP1 | GLIS3-AS1 | 0.658299 | 3 | 0 | 3 |
| MAPK8IP1 | GPAT2 | 0.658204 | 3 | 0 | 3 |
| MAPK8IP1 | SLC25A48 | 0.656983 | 3 | 0 | 3 |
| MAPK8IP1 | C19orf71 | 0.656787 | 3 | 0 | 3 |
| MAPK8IP1 | GADL1 | 0.656119 | 3 | 0 | 3 |
| MAPK8IP1 | WDR87 | 0.655851 | 5 | 0 | 4 |
| MAPK8IP1 | LCN8 | 0.654219 | 5 | 0 | 4 |
For details and further investigation, click here
