| Full name: complement component 4 binding protein beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 725 | HGNC ID: HGNC:1328 | Ensembl Gene: ENSG00000123843 | OMIM ID: 120831 |
| Drug and gene relationship at DGIdb | |||
C4BPB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05133 | Pertussis |
Expression of C4BPB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | C4BPB | 725 | 208209_s_at | -0.0323 | 0.9082 | |
| GSE20347 | C4BPB | 725 | 208209_s_at | -0.1062 | 0.1505 | |
| GSE23400 | C4BPB | 725 | 208209_s_at | -0.0511 | 0.0404 | |
| GSE26886 | C4BPB | 725 | 208209_s_at | 0.0532 | 0.7511 | |
| GSE29001 | C4BPB | 725 | 208209_s_at | -0.0916 | 0.5186 | |
| GSE38129 | C4BPB | 725 | 208209_s_at | -0.2023 | 0.0261 | |
| GSE45670 | C4BPB | 725 | 208209_s_at | -0.0850 | 0.3531 | |
| GSE53622 | C4BPB | 725 | 13682 | -0.4872 | 0.0154 | |
| GSE53624 | C4BPB | 725 | 13682 | -0.5847 | 0.0002 | |
| GSE63941 | C4BPB | 725 | 208209_s_at | 0.1192 | 0.5759 | |
| GSE77861 | C4BPB | 725 | 208209_s_at | -0.2883 | 0.0145 | |
| GSE97050 | C4BPB | 725 | A_23_P319598 | 0.1487 | 0.4753 | |
| TCGA | C4BPB | 725 | RNAseq | -4.2061 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by C4BPB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of C4BPB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | C4BPB | 725 | 11 | 0 | 19 | |
| GSE20123 | C4BPB | 725 | 11 | 0 | 19 | |
| GSE43470 | C4BPB | 725 | 8 | 0 | 35 | |
| GSE46452 | C4BPB | 725 | 3 | 1 | 55 | |
| GSE47630 | C4BPB | 725 | 14 | 0 | 26 | |
| GSE54993 | C4BPB | 725 | 0 | 6 | 64 | |
| GSE54994 | C4BPB | 725 | 14 | 0 | 39 | |
| GSE60625 | C4BPB | 725 | 0 | 0 | 11 | |
| GSE74703 | C4BPB | 725 | 8 | 0 | 28 | |
| GSE74704 | C4BPB | 725 | 5 | 0 | 15 | |
| TCGA | C4BPB | 725 | 45 | 3 | 48 |
Total number of gains: 119; Total number of losses: 10; Total Number of normals: 359.
Somatic mutations of C4BPB:
Generating mutation plots.
Highly correlated genes for C4BPB:
Showing top 20/645 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| C4BPB | BSND | 0.720949 | 3 | 0 | 3 |
| C4BPB | FATE1 | 0.71748 | 3 | 0 | 3 |
| C4BPB | ENHO | 0.703243 | 3 | 0 | 3 |
| C4BPB | PAX8 | 0.696865 | 6 | 0 | 6 |
| C4BPB | SLC6A7 | 0.693418 | 4 | 0 | 3 |
| C4BPB | TAAR5 | 0.690144 | 4 | 0 | 4 |
| C4BPB | NANOG | 0.687365 | 5 | 0 | 4 |
| C4BPB | MAPK8IP1 | 0.681575 | 4 | 0 | 3 |
| C4BPB | LTA | 0.674223 | 4 | 0 | 4 |
| C4BPB | HUS1B | 0.673383 | 4 | 0 | 3 |
| C4BPB | AOC2 | 0.671849 | 3 | 0 | 3 |
| C4BPB | SOHLH1 | 0.671392 | 3 | 0 | 3 |
| C4BPB | GRM2 | 0.670287 | 5 | 0 | 4 |
| C4BPB | LMAN1L | 0.669056 | 8 | 0 | 7 |
| C4BPB | DIO3 | 0.667588 | 3 | 0 | 3 |
| C4BPB | KCNJ4 | 0.666074 | 3 | 0 | 3 |
| C4BPB | KSR1 | 0.664129 | 5 | 0 | 4 |
| C4BPB | KRTAP1-1 | 0.663916 | 5 | 0 | 5 |
| C4BPB | PAPOLB | 0.659012 | 3 | 0 | 3 |
| C4BPB | MEPE | 0.657597 | 4 | 0 | 4 |
For details and further investigation, click here
