| Full name: leukotriene C4 synthase | Alias Symbol: MGC33147 | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 4056 | HGNC ID: HGNC:6719 | Ensembl Gene: ENSG00000213316 | OMIM ID: 246530 |
| Drug and gene relationship at DGIdb | |||
Expression of LTC4S:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LTC4S | 4056 | 206480_at | -0.2231 | 0.4694 | |
| GSE20347 | LTC4S | 4056 | 206480_at | -0.1914 | 0.0040 | |
| GSE23400 | LTC4S | 4056 | 206480_at | -0.1805 | 0.0000 | |
| GSE26886 | LTC4S | 4056 | 206480_at | 0.2070 | 0.0644 | |
| GSE29001 | LTC4S | 4056 | 206480_at | -0.1864 | 0.0528 | |
| GSE38129 | LTC4S | 4056 | 206480_at | -0.2754 | 0.0032 | |
| GSE45670 | LTC4S | 4056 | 206480_at | -0.4293 | 0.0008 | |
| GSE53622 | LTC4S | 4056 | 83748 | -0.2487 | 0.0000 | |
| GSE53624 | LTC4S | 4056 | 83748 | -0.3955 | 0.0000 | |
| GSE63941 | LTC4S | 4056 | 206480_at | 0.0004 | 0.9985 | |
| GSE77861 | LTC4S | 4056 | 206480_at | -0.0313 | 0.8255 | |
| GSE97050 | LTC4S | 4056 | A_24_P397294 | -0.0922 | 0.6618 | |
| SRP064894 | LTC4S | 4056 | RNAseq | -1.2615 | 0.0051 | |
| SRP133303 | LTC4S | 4056 | RNAseq | -1.2188 | 0.0001 | |
| SRP159526 | LTC4S | 4056 | RNAseq | -0.9885 | 0.1128 | |
| SRP219564 | LTC4S | 4056 | RNAseq | 0.0563 | 0.9218 | |
| TCGA | LTC4S | 4056 | RNAseq | -0.7434 | 0.0024 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LTC4S expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LTC4S:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LTC4S | 4056 | 2 | 12 | 16 | |
| GSE20123 | LTC4S | 4056 | 2 | 12 | 16 | |
| GSE43470 | LTC4S | 4056 | 1 | 11 | 31 | |
| GSE46452 | LTC4S | 4056 | 0 | 27 | 32 | |
| GSE47630 | LTC4S | 4056 | 1 | 20 | 19 | |
| GSE54993 | LTC4S | 4056 | 10 | 2 | 58 | |
| GSE54994 | LTC4S | 4056 | 2 | 17 | 34 | |
| GSE60625 | LTC4S | 4056 | 1 | 0 | 10 | |
| GSE74703 | LTC4S | 4056 | 1 | 7 | 28 | |
| GSE74704 | LTC4S | 4056 | 1 | 6 | 13 | |
| TCGA | LTC4S | 4056 | 11 | 34 | 51 |
Total number of gains: 32; Total number of losses: 148; Total Number of normals: 308.
Somatic mutations of LTC4S:
Generating mutation plots.
Highly correlated genes for LTC4S:
Showing top 20/263 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LTC4S | LRRC46 | 0.782945 | 3 | 0 | 3 |
| LTC4S | PNPLA5 | 0.756644 | 3 | 0 | 3 |
| LTC4S | C16orf89 | 0.75599 | 3 | 0 | 3 |
| LTC4S | ZNF524 | 0.736788 | 3 | 0 | 3 |
| LTC4S | LRFN2 | 0.736661 | 3 | 0 | 3 |
| LTC4S | MAPK8IP1 | 0.736561 | 3 | 0 | 3 |
| LTC4S | C19orf81 | 0.734753 | 3 | 0 | 3 |
| LTC4S | CEBPE | 0.726352 | 4 | 0 | 4 |
| LTC4S | ARMC5 | 0.726173 | 3 | 0 | 3 |
| LTC4S | PPM1J | 0.725192 | 3 | 0 | 3 |
| LTC4S | ORM1 | 0.718251 | 3 | 0 | 3 |
| LTC4S | NCR3 | 0.7128 | 4 | 0 | 4 |
| LTC4S | SYCE3 | 0.712265 | 3 | 0 | 3 |
| LTC4S | CPNE9 | 0.711025 | 3 | 0 | 3 |
| LTC4S | CCDC33 | 0.70774 | 3 | 0 | 3 |
| LTC4S | CHRD | 0.706945 | 3 | 0 | 3 |
| LTC4S | MAMLD1 | 0.696545 | 3 | 0 | 3 |
| LTC4S | PHOSPHO1 | 0.693646 | 3 | 0 | 3 |
| LTC4S | CHD5 | 0.693457 | 4 | 0 | 4 |
| LTC4S | TUBA8 | 0.689894 | 3 | 0 | 3 |
For details and further investigation, click here
