| Full name: MAP3K12 binding inhibitory protein 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q13.3 | ||
| Entrez ID: 51562 | HGNC ID: HGNC:20427 | Ensembl Gene: ENSG00000151332 | OMIM ID: 609431 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MBIP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MBIP | 51562 | 218411_s_at | 0.4224 | 0.6471 | |
| GSE20347 | MBIP | 51562 | 218411_s_at | 0.7667 | 0.0033 | |
| GSE23400 | MBIP | 51562 | 218411_s_at | 0.2714 | 0.0000 | |
| GSE26886 | MBIP | 51562 | 218411_s_at | 0.4697 | 0.0242 | |
| GSE29001 | MBIP | 51562 | 218411_s_at | 0.6808 | 0.0091 | |
| GSE38129 | MBIP | 51562 | 218411_s_at | 0.4729 | 0.0194 | |
| GSE45670 | MBIP | 51562 | 218411_s_at | 0.2107 | 0.1794 | |
| GSE53622 | MBIP | 51562 | 119125 | 0.7003 | 0.0000 | |
| GSE53624 | MBIP | 51562 | 119125 | 0.4743 | 0.0000 | |
| GSE63941 | MBIP | 51562 | 218411_s_at | 0.2480 | 0.7308 | |
| GSE77861 | MBIP | 51562 | 218411_s_at | 0.5128 | 0.2118 | |
| GSE97050 | MBIP | 51562 | A_33_P3288569 | 0.7689 | 0.1015 | |
| SRP007169 | MBIP | 51562 | RNAseq | 0.9154 | 0.0587 | |
| SRP008496 | MBIP | 51562 | RNAseq | 0.5633 | 0.1287 | |
| SRP064894 | MBIP | 51562 | RNAseq | 0.3200 | 0.0659 | |
| SRP133303 | MBIP | 51562 | RNAseq | 0.6021 | 0.0001 | |
| SRP159526 | MBIP | 51562 | RNAseq | 0.4010 | 0.0878 | |
| SRP193095 | MBIP | 51562 | RNAseq | 0.2440 | 0.1275 | |
| SRP219564 | MBIP | 51562 | RNAseq | 0.4072 | 0.2531 | |
| TCGA | MBIP | 51562 | RNAseq | -0.0849 | 0.2077 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MBIP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MBIP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MBIP | 51562 | 11 | 4 | 15 | |
| GSE20123 | MBIP | 51562 | 12 | 4 | 14 | |
| GSE43470 | MBIP | 51562 | 9 | 3 | 31 | |
| GSE46452 | MBIP | 51562 | 18 | 2 | 39 | |
| GSE47630 | MBIP | 51562 | 12 | 9 | 19 | |
| GSE54993 | MBIP | 51562 | 3 | 11 | 56 | |
| GSE54994 | MBIP | 51562 | 19 | 5 | 29 | |
| GSE60625 | MBIP | 51562 | 0 | 2 | 9 | |
| GSE74703 | MBIP | 51562 | 8 | 3 | 25 | |
| GSE74704 | MBIP | 51562 | 6 | 3 | 11 | |
| TCGA | MBIP | 51562 | 35 | 14 | 47 |
Total number of gains: 133; Total number of losses: 60; Total Number of normals: 295.
Somatic mutations of MBIP:
Generating mutation plots.
Highly correlated genes for MBIP:
Showing top 20/529 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MBIP | SFPQ | 0.741606 | 3 | 0 | 3 |
| MBIP | SRP54 | 0.737547 | 12 | 0 | 12 |
| MBIP | CHML | 0.699623 | 3 | 0 | 3 |
| MBIP | DCK | 0.693991 | 3 | 0 | 3 |
| MBIP | USP3 | 0.691413 | 3 | 0 | 3 |
| MBIP | MEAF6 | 0.68713 | 3 | 0 | 3 |
| MBIP | USP34 | 0.681394 | 3 | 0 | 3 |
| MBIP | FAM168A | 0.674632 | 4 | 0 | 4 |
| MBIP | ZFX | 0.669613 | 3 | 0 | 3 |
| MBIP | FAM177A1 | 0.667859 | 3 | 0 | 3 |
| MBIP | UHRF1BP1 | 0.667769 | 3 | 0 | 3 |
| MBIP | EIF1AX | 0.665555 | 3 | 0 | 3 |
| MBIP | MIPOL1 | 0.66326 | 7 | 0 | 6 |
| MBIP | ACBD5 | 0.662671 | 3 | 0 | 3 |
| MBIP | MYC | 0.658684 | 3 | 0 | 3 |
| MBIP | NEK11 | 0.658545 | 4 | 0 | 3 |
| MBIP | SRSF10 | 0.657503 | 6 | 0 | 5 |
| MBIP | ZNF668 | 0.657394 | 3 | 0 | 3 |
| MBIP | DHX8 | 0.657049 | 3 | 0 | 3 |
| MBIP | SLC38A6 | 0.65385 | 8 | 0 | 8 |
For details and further investigation, click here
