MYC

 

Full name: MYC proto-oncogene, bHLH transcription factor Alias Symbol: c-Myc|bHLHe39|MYCC
Type: protein-coding gene Cytoband: 8q24.21
Entrez ID: 4609 HGNC ID: HGNC:7553 Ensembl Gene: ENSG00000136997 OMIM ID: 190080
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 282/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MYC involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04110Cell cycle
hsa04151PI3K-Akt signaling pathway
hsa04310Wnt signaling pathway
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04630Jak-STAT signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa05216Thyroid cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer

 

Expression of MYC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MYC 4609 202431_s_at 0.0910 0.9259
GSE20347 MYC 4609 202431_s_at 0.7150 0.0065
GSE23400 MYC 4609 202431_s_at 0.5593 0.0008
GSE26886 MYC 4609 202431_s_at 0.8820 0.0010
GSE29001 MYC 4609 202431_s_at 0.0751 0.8981
GSE38129 MYC 4609 202431_s_at 0.4957 0.0678
GSE45670 MYC 4609 202431_s_at -0.0418 0.8655
GSE53622 MYC 4609 122219 0.1339 0.3067
GSE53624 MYC 4609 122219 0.2869 0.0041
GSE63941 MYC 4609 202431_s_at 1.8794 0.0678
GSE77861 MYC 4609 202431_s_at 0.3858 0.3075
GSE97050 MYC 4609 A_23_P215956 0.5023 0.2027
SRP007169 MYC 4609 RNAseq 0.2568 0.5394
SRP008496 MYC 4609 RNAseq 0.0490 0.8663
SRP064894 MYC 4609 RNAseq -0.3249 0.2076
SRP133303 MYC 4609 RNAseq 0.1212 0.6231
SRP159526 MYC 4609 RNAseq -0.4064 0.2398
SRP193095 MYC 4609 RNAseq 0.4238 0.0618
SRP219564 MYC 4609 RNAseq -0.2088 0.6812
TCGA MYC 4609 RNAseq 0.1769 0.0104

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MYC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MYC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MYC 4609 22 0 8
GSE20123 MYC 4609 22 0 8
GSE43470 MYC 4609 23 0 20
GSE46452 MYC 4609 30 0 29
GSE47630 MYC 4609 25 0 15
GSE54993 MYC 4609 0 23 47
GSE54994 MYC 4609 41 0 12
GSE60625 MYC 4609 0 7 4
GSE74703 MYC 4609 19 0 17
GSE74704 MYC 4609 15 0 5
TCGA MYC 4609 70 1 25

Total number of gains: 267; Total number of losses: 31; Total Number of normals: 190.  

 

Somatic mutations of MYC:

 

Generating mutation plots.

 

Highly correlated genes for MYC:

 

Showing top 20/433 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MYCB3GNT90.777592303
MYCSDR39U10.739283303
MYCNGF0.738448303
MYCZSCAN210.732624303
MYCTTC7B0.732516404
MYCKPNA50.714636303
MYCRNF19A0.71343303
MYCPPP1R350.712681303
MYCNAF10.706881303
MYCMED170.703837505
MYCPRTFDC10.703615403
MYCAP2B10.696718303
MYCPLOD30.696062303
MYCZFP10.69222303
MYCTBX180.689648303
MYCSPAG70.681957403
MYCZFP900.680243403
MYCARL100.680194303
MYCRRAS0.679588404
MYCNAP1L50.676985303

For details and further investigation, click here