| Full name: ubiquitin specific peptidase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q22.31 | ||
| Entrez ID: 9960 | HGNC ID: HGNC:12626 | Ensembl Gene: ENSG00000140455 | OMIM ID: 604728 |
| Drug and gene relationship at DGIdb | |||
Expression of USP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP3 | 9960 | 221654_s_at | 0.0809 | 0.8641 | |
| GSE20347 | USP3 | 9960 | 221654_s_at | 0.1652 | 0.3684 | |
| GSE23400 | USP3 | 9960 | 221654_s_at | 0.1855 | 0.0218 | |
| GSE26886 | USP3 | 9960 | 221654_s_at | 0.4228 | 0.0750 | |
| GSE29001 | USP3 | 9960 | 221654_s_at | -0.0764 | 0.8219 | |
| GSE38129 | USP3 | 9960 | 221654_s_at | 0.2846 | 0.0428 | |
| GSE45670 | USP3 | 9960 | 221654_s_at | 0.0252 | 0.8810 | |
| GSE63941 | USP3 | 9960 | 221654_s_at | 0.7349 | 0.0814 | |
| GSE77861 | USP3 | 9960 | 221654_s_at | 0.6318 | 0.1067 | |
| GSE97050 | USP3 | 9960 | A_33_P3231110 | 0.1156 | 0.5852 | |
| SRP007169 | USP3 | 9960 | RNAseq | -0.3086 | 0.4507 | |
| SRP008496 | USP3 | 9960 | RNAseq | -0.1163 | 0.6415 | |
| SRP064894 | USP3 | 9960 | RNAseq | -0.2598 | 0.0492 | |
| SRP133303 | USP3 | 9960 | RNAseq | 0.0868 | 0.4992 | |
| SRP159526 | USP3 | 9960 | RNAseq | -0.3743 | 0.2223 | |
| SRP193095 | USP3 | 9960 | RNAseq | -0.0766 | 0.4026 | |
| SRP219564 | USP3 | 9960 | RNAseq | -0.2063 | 0.5103 | |
| TCGA | USP3 | 9960 | RNAseq | -0.1194 | 0.0246 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by USP3 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of USP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP3 | 9960 | 8 | 2 | 20 | |
| GSE20123 | USP3 | 9960 | 8 | 2 | 20 | |
| GSE43470 | USP3 | 9960 | 4 | 6 | 33 | |
| GSE46452 | USP3 | 9960 | 3 | 7 | 49 | |
| GSE47630 | USP3 | 9960 | 8 | 10 | 22 | |
| GSE54993 | USP3 | 9960 | 5 | 6 | 59 | |
| GSE54994 | USP3 | 9960 | 6 | 8 | 39 | |
| GSE60625 | USP3 | 9960 | 4 | 0 | 7 | |
| GSE74703 | USP3 | 9960 | 4 | 3 | 29 | |
| GSE74704 | USP3 | 9960 | 4 | 2 | 14 | |
| TCGA | USP3 | 9960 | 10 | 16 | 70 |
Total number of gains: 64; Total number of losses: 62; Total Number of normals: 362.
Somatic mutations of USP3:
Generating mutation plots.
Highly correlated genes for USP3:
Showing top 20/261 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP3 | PIGS | 0.763297 | 3 | 0 | 3 |
| USP3 | CHCHD5 | 0.757025 | 3 | 0 | 3 |
| USP3 | BCKDK | 0.755009 | 3 | 0 | 3 |
| USP3 | MRPL21 | 0.74966 | 3 | 0 | 3 |
| USP3 | REPIN1 | 0.74941 | 3 | 0 | 3 |
| USP3 | SMARCA5 | 0.748908 | 3 | 0 | 3 |
| USP3 | MRPS18A | 0.74615 | 3 | 0 | 3 |
| USP3 | C17orf75 | 0.745473 | 3 | 0 | 3 |
| USP3 | LSM10 | 0.743806 | 3 | 0 | 3 |
| USP3 | DNTTIP1 | 0.735391 | 3 | 0 | 3 |
| USP3 | PSMA5 | 0.733746 | 3 | 0 | 3 |
| USP3 | BRMS1L | 0.730723 | 3 | 0 | 3 |
| USP3 | TTI2 | 0.711563 | 3 | 0 | 3 |
| USP3 | RBM22 | 0.711474 | 3 | 0 | 3 |
| USP3 | MGAT4A | 0.704256 | 3 | 0 | 3 |
| USP3 | CCT4 | 0.702276 | 3 | 0 | 3 |
| USP3 | SUB1 | 0.699518 | 3 | 0 | 3 |
| USP3 | EIF2S2 | 0.698696 | 4 | 0 | 4 |
| USP3 | NAIF1 | 0.698496 | 3 | 0 | 3 |
| USP3 | ARFIP1 | 0.698452 | 3 | 0 | 3 |
For details and further investigation, click here
