| Full name: serine and arginine rich splicing factor 10 | Alias Symbol: TASR1|TASR2|SRp38|SRrp40|SFRS13|PPP1R149 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 10772 | HGNC ID: HGNC:16713 | Ensembl Gene: ENSG00000188529 | OMIM ID: 605221 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SRSF10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRSF10 | 10772 | 206095_s_at | 0.2799 | 0.3299 | |
| GSE20347 | SRSF10 | 10772 | 206095_s_at | 0.2319 | 0.0834 | |
| GSE23400 | SRSF10 | 10772 | 213594_x_at | 0.7022 | 0.0000 | |
| GSE26886 | SRSF10 | 10772 | 206095_s_at | -0.9238 | 0.0006 | |
| GSE29001 | SRSF10 | 10772 | 206095_s_at | 0.6534 | 0.0151 | |
| GSE38129 | SRSF10 | 10772 | 206095_s_at | 0.2933 | 0.0181 | |
| GSE45670 | SRSF10 | 10772 | 206095_s_at | 0.1977 | 0.1037 | |
| GSE53622 | SRSF10 | 10772 | 69993 | 0.6347 | 0.0000 | |
| GSE53624 | SRSF10 | 10772 | 69993 | 0.6098 | 0.0000 | |
| GSE63941 | SRSF10 | 10772 | 206095_s_at | -0.0392 | 0.9036 | |
| GSE77861 | SRSF10 | 10772 | 206095_s_at | 0.0445 | 0.8715 | |
| GSE97050 | SRSF10 | 10772 | A_33_P3303215 | 0.4534 | 0.1399 | |
| SRP007169 | SRSF10 | 10772 | RNAseq | 0.2615 | 0.4285 | |
| SRP008496 | SRSF10 | 10772 | RNAseq | 0.2386 | 0.2144 | |
| SRP064894 | SRSF10 | 10772 | RNAseq | 0.3477 | 0.0875 | |
| SRP133303 | SRSF10 | 10772 | RNAseq | 0.4819 | 0.0002 | |
| SRP159526 | SRSF10 | 10772 | RNAseq | 0.3769 | 0.0839 | |
| SRP193095 | SRSF10 | 10772 | RNAseq | 0.1630 | 0.0265 | |
| SRP219564 | SRSF10 | 10772 | RNAseq | 0.0824 | 0.6545 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SRSF10 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF10 | 10772 | 0 | 5 | 25 | |
| GSE20123 | SRSF10 | 10772 | 0 | 4 | 26 | |
| GSE43470 | SRSF10 | 10772 | 2 | 6 | 35 | |
| GSE46452 | SRSF10 | 10772 | 5 | 1 | 53 | |
| GSE47630 | SRSF10 | 10772 | 8 | 3 | 29 | |
| GSE54993 | SRSF10 | 10772 | 2 | 1 | 67 | |
| GSE54994 | SRSF10 | 10772 | 11 | 4 | 38 | |
| GSE60625 | SRSF10 | 10772 | 0 | 0 | 11 | |
| GSE74703 | SRSF10 | 10772 | 1 | 4 | 31 | |
| GSE74704 | SRSF10 | 10772 | 0 | 0 | 20 | |
| TCGA | SRSF10 | 10772 | 9 | 24 | 63 |
Total number of gains: 38; Total number of losses: 52; Total Number of normals: 398.
Somatic mutations of SRSF10:
Generating mutation plots.
Highly correlated genes for SRSF10:
Showing top 20/1089 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF10 | C2CD2 | 0.835668 | 3 | 0 | 3 |
| SRSF10 | GNG10 | 0.794321 | 3 | 0 | 3 |
| SRSF10 | MAD2L2 | 0.78745 | 4 | 0 | 4 |
| SRSF10 | FAM161A | 0.762554 | 3 | 0 | 3 |
| SRSF10 | KCTD15 | 0.760648 | 3 | 0 | 3 |
| SRSF10 | HMGN1 | 0.755461 | 3 | 0 | 3 |
| SRSF10 | GSPT2 | 0.750677 | 3 | 0 | 3 |
| SRSF10 | HNRNPR | 0.74919 | 10 | 0 | 10 |
| SRSF10 | STX10 | 0.748939 | 3 | 0 | 3 |
| SRSF10 | HEATR5A | 0.748657 | 3 | 0 | 3 |
| SRSF10 | SYNGR3 | 0.745392 | 3 | 0 | 3 |
| SRSF10 | FOXK2 | 0.743102 | 4 | 0 | 4 |
| SRSF10 | FBXW8 | 0.738495 | 3 | 0 | 3 |
| SRSF10 | ZBTB2 | 0.735667 | 4 | 0 | 4 |
| SRSF10 | MRPL51 | 0.732843 | 4 | 0 | 4 |
| SRSF10 | AP3M1 | 0.731613 | 3 | 0 | 3 |
| SRSF10 | VPS26B | 0.730898 | 3 | 0 | 3 |
| SRSF10 | MSL3 | 0.727051 | 3 | 0 | 3 |
| SRSF10 | NUDT19 | 0.725604 | 3 | 0 | 3 |
| SRSF10 | UBE3C | 0.717423 | 5 | 0 | 4 |
For details and further investigation, click here
