| Full name: DEAH-box helicase 8 | Alias Symbol: HRH1|PRP22|PRPF22|Dhr2 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 1659 | HGNC ID: HGNC:2749 | Ensembl Gene: | OMIM ID: 600396 |
| Drug and gene relationship at DGIdb | |||
Expression of DHX8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHX8 | 1659 | 203334_at | 0.3368 | 0.3861 | |
| GSE20347 | DHX8 | 1659 | 203334_at | 0.0302 | 0.8319 | |
| GSE23400 | DHX8 | 1659 | 203334_at | 0.2776 | 0.0000 | |
| GSE26886 | DHX8 | 1659 | 227079_at | 0.3469 | 0.0351 | |
| GSE29001 | DHX8 | 1659 | 203334_at | 0.1528 | 0.6079 | |
| GSE38129 | DHX8 | 1659 | 203334_at | 0.3282 | 0.0069 | |
| GSE45670 | DHX8 | 1659 | 203334_at | 0.3273 | 0.0023 | |
| GSE53622 | DHX8 | 1659 | 72673 | 0.2727 | 0.0000 | |
| GSE53624 | DHX8 | 1659 | 21003 | 0.1524 | 0.0017 | |
| GSE63941 | DHX8 | 1659 | 203334_at | 0.8761 | 0.0083 | |
| GSE77861 | DHX8 | 1659 | 203334_at | 0.4344 | 0.1282 | |
| GSE97050 | DHX8 | 1659 | A_23_P124224 | 0.2013 | 0.3192 | |
| SRP007169 | DHX8 | 1659 | RNAseq | 0.8001 | 0.0554 | |
| SRP008496 | DHX8 | 1659 | RNAseq | 0.6603 | 0.0135 | |
| SRP064894 | DHX8 | 1659 | RNAseq | 0.2442 | 0.0194 | |
| SRP133303 | DHX8 | 1659 | RNAseq | 0.1728 | 0.1930 | |
| SRP159526 | DHX8 | 1659 | RNAseq | 0.1891 | 0.3071 | |
| SRP193095 | DHX8 | 1659 | RNAseq | 0.1346 | 0.0407 | |
| SRP219564 | DHX8 | 1659 | RNAseq | -0.0525 | 0.8628 | |
| TCGA | DHX8 | 1659 | RNAseq | 0.0998 | 0.0340 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DHX8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHX8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHX8 | 1659 | 5 | 2 | 23 | |
| GSE20123 | DHX8 | 1659 | 5 | 2 | 23 | |
| GSE43470 | DHX8 | 1659 | 1 | 2 | 40 | |
| GSE46452 | DHX8 | 1659 | 34 | 0 | 25 | |
| GSE47630 | DHX8 | 1659 | 8 | 1 | 31 | |
| GSE54993 | DHX8 | 1659 | 3 | 4 | 63 | |
| GSE54994 | DHX8 | 1659 | 8 | 5 | 40 | |
| GSE60625 | DHX8 | 1659 | 4 | 0 | 7 | |
| GSE74703 | DHX8 | 1659 | 1 | 1 | 34 | |
| GSE74704 | DHX8 | 1659 | 3 | 1 | 16 | |
| TCGA | DHX8 | 1659 | 25 | 6 | 65 |
Total number of gains: 97; Total number of losses: 24; Total Number of normals: 367.
Somatic mutations of DHX8:
Generating mutation plots.
Highly correlated genes for DHX8:
Showing top 20/810 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHX8 | CEP63 | 0.770436 | 3 | 0 | 3 |
| DHX8 | NRARP | 0.763807 | 3 | 0 | 3 |
| DHX8 | PRELID1 | 0.75222 | 3 | 0 | 3 |
| DHX8 | ARFGEF2 | 0.747674 | 3 | 0 | 3 |
| DHX8 | DIP2B | 0.74351 | 4 | 0 | 4 |
| DHX8 | TCEANC2 | 0.722869 | 3 | 0 | 3 |
| DHX8 | GMCL1 | 0.719359 | 4 | 0 | 4 |
| DHX8 | VRK3 | 0.716004 | 3 | 0 | 3 |
| DHX8 | NUB1 | 0.707012 | 3 | 0 | 3 |
| DHX8 | KTI12 | 0.700382 | 3 | 0 | 3 |
| DHX8 | RAP1B | 0.695762 | 3 | 0 | 3 |
| DHX8 | EFTUD2 | 0.692541 | 8 | 0 | 7 |
| DHX8 | SFT2D3 | 0.691045 | 3 | 0 | 3 |
| DHX8 | MRPL37 | 0.687918 | 5 | 0 | 5 |
| DHX8 | STAU1 | 0.685376 | 4 | 0 | 3 |
| DHX8 | LMBR1 | 0.684906 | 4 | 0 | 3 |
| DHX8 | NOL9 | 0.676195 | 3 | 0 | 3 |
| DHX8 | PPP4C | 0.675996 | 7 | 0 | 6 |
| DHX8 | NFKB1 | 0.675313 | 5 | 0 | 4 |
| DHX8 | GPR160 | 0.673672 | 4 | 0 | 3 |
For details and further investigation, click here
