SRP54

 

Full name: signal recognition particle 54 Alias Symbol: 
Type: protein-coding gene Cytoband: 14q13.2
Entrez ID: 6729 HGNC ID: HGNC:11301 Ensembl Gene: ENSG00000100883 OMIM ID: 604857
Drug and gene relationship at DGIdb

 

Expression of SRP54:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SRP54 6729 203605_at 0.6619 0.4738
GSE20347 SRP54 6729 203605_at 0.6332 0.0028
GSE23400 SRP54 6729 203605_at 0.5929 0.0000
GSE26886 SRP54 6729 203605_at -0.2517 0.2116
GSE29001 SRP54 6729 203605_at 0.5029 0.0214
GSE38129 SRP54 6729 203605_at 0.5992 0.0001
GSE45670 SRP54 6729 203605_at 0.3173 0.0124
GSE53622 SRP54 6729 120732 0.5605 0.0000
GSE53624 SRP54 6729 120732 0.2933 0.0000
GSE63941 SRP54 6729 203605_at 0.0413 0.9363
GSE77861 SRP54 6729 203605_at 0.8568 0.2654
GSE97050 SRP54 6729 A_23_P162945 0.5521 0.1241
SRP007169 SRP54 6729 RNAseq 0.0939 0.7926
SRP008496 SRP54 6729 RNAseq -0.1705 0.4800
SRP064894 SRP54 6729 RNAseq 0.2424 0.2420
SRP133303 SRP54 6729 RNAseq 0.8979 0.0013
SRP159526 SRP54 6729 RNAseq 0.0968 0.7211
SRP193095 SRP54 6729 RNAseq 0.0126 0.9063
SRP219564 SRP54 6729 RNAseq 0.3893 0.4259
TCGA SRP54 6729 RNAseq 0.0561 0.2809

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by SRP54 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SRP54:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SRP54 6729 10 4 16
GSE20123 SRP54 6729 11 4 15
GSE43470 SRP54 6729 9 2 32
GSE46452 SRP54 6729 18 2 39
GSE47630 SRP54 6729 11 10 19
GSE54993 SRP54 6729 3 10 57
GSE54994 SRP54 6729 19 5 29
GSE60625 SRP54 6729 0 2 9
GSE74703 SRP54 6729 8 2 26
GSE74704 SRP54 6729 5 3 12
TCGA SRP54 6729 32 15 49

Total number of gains: 126; Total number of losses: 59; Total Number of normals: 303.  

 

Somatic mutations of SRP54:

 

Generating mutation plots.

 

Highly correlated genes for SRP54:

 

Showing top 20/673 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SRP54SNX60.7738110010
SRP54VPS33A0.751293303
SRP54MBIP0.73754712012
SRP54BAZ1A0.72592712012
SRP54FAM177A10.710274303
SRP54AP3D10.69449303
SRP54FCHSD20.692324303
SRP54SLC38A60.6847707
SRP54STAG10.68136303
SRP54ZNF350.678379303
SRP54SASS60.676729303
SRP54CCDC240.672928303
SRP54MNAT10.669181909
SRP54SIX40.660417404
SRP54MGAT20.659504806
SRP54EIF2AK10.658309606
SRP54G2E30.654441706
SRP54HPRT10.652978808
SRP54BRMS1L0.652158908
SRP54GET40.651755303

For details and further investigation, click here