| Full name: NIMA related kinase 11 | Alias Symbol: FLJ23495 | ||
| Type: protein-coding gene | Cytoband: 3q22.1 | ||
| Entrez ID: 79858 | HGNC ID: HGNC:18593 | Ensembl Gene: ENSG00000114670 | OMIM ID: 609779 |
| Drug and gene relationship at DGIdb | |||
Expression of NEK11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NEK11 | 79858 | 219542_at | 0.3347 | 0.5219 | |
| GSE20347 | NEK11 | 79858 | 219542_at | -0.1380 | 0.3157 | |
| GSE23400 | NEK11 | 79858 | 219542_at | -0.1707 | 0.0003 | |
| GSE26886 | NEK11 | 79858 | 219542_at | 0.1608 | 0.6533 | |
| GSE29001 | NEK11 | 79858 | 219542_at | 0.0949 | 0.6305 | |
| GSE38129 | NEK11 | 79858 | 219542_at | -0.2056 | 0.0942 | |
| GSE45670 | NEK11 | 79858 | 219542_at | 0.0227 | 0.9157 | |
| GSE53622 | NEK11 | 79858 | 19597 | 0.1895 | 0.1414 | |
| GSE53624 | NEK11 | 79858 | 19597 | 0.3407 | 0.0006 | |
| GSE63941 | NEK11 | 79858 | 219542_at | -0.4394 | 0.3934 | |
| GSE77861 | NEK11 | 79858 | 1555082_a_at | 0.0640 | 0.6497 | |
| GSE97050 | NEK11 | 79858 | A_23_P211973 | 0.0646 | 0.8324 | |
| SRP007169 | NEK11 | 79858 | RNAseq | -0.4945 | 0.3482 | |
| SRP008496 | NEK11 | 79858 | RNAseq | 0.2115 | 0.6675 | |
| SRP064894 | NEK11 | 79858 | RNAseq | 0.6236 | 0.0032 | |
| SRP133303 | NEK11 | 79858 | RNAseq | 0.2615 | 0.1919 | |
| SRP159526 | NEK11 | 79858 | RNAseq | 0.2722 | 0.5223 | |
| SRP193095 | NEK11 | 79858 | RNAseq | 0.4901 | 0.0003 | |
| SRP219564 | NEK11 | 79858 | RNAseq | 0.2483 | 0.5237 | |
| TCGA | NEK11 | 79858 | RNAseq | 0.2391 | 0.0903 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NEK11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NEK11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NEK11 | 79858 | 16 | 0 | 14 | |
| GSE20123 | NEK11 | 79858 | 16 | 0 | 14 | |
| GSE43470 | NEK11 | 79858 | 21 | 0 | 22 | |
| GSE46452 | NEK11 | 79858 | 15 | 4 | 40 | |
| GSE47630 | NEK11 | 79858 | 18 | 3 | 19 | |
| GSE54993 | NEK11 | 79858 | 2 | 8 | 60 | |
| GSE54994 | NEK11 | 79858 | 32 | 3 | 18 | |
| GSE60625 | NEK11 | 79858 | 0 | 6 | 5 | |
| GSE74703 | NEK11 | 79858 | 18 | 0 | 18 | |
| GSE74704 | NEK11 | 79858 | 12 | 0 | 8 | |
| TCGA | NEK11 | 79858 | 58 | 9 | 29 |
Total number of gains: 208; Total number of losses: 33; Total Number of normals: 247.
Somatic mutations of NEK11:
Generating mutation plots.
Highly correlated genes for NEK11:
Showing top 20/138 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NEK11 | NQO2 | 0.765384 | 3 | 0 | 3 |
| NEK11 | PTPN1 | 0.733656 | 3 | 0 | 3 |
| NEK11 | CPNE1 | 0.731224 | 3 | 0 | 3 |
| NEK11 | RNF187 | 0.721002 | 3 | 0 | 3 |
| NEK11 | SLC35E3 | 0.720348 | 4 | 0 | 4 |
| NEK11 | HFE | 0.710879 | 3 | 0 | 3 |
| NEK11 | ISCA2 | 0.709696 | 3 | 0 | 3 |
| NEK11 | ADAM11 | 0.70545 | 3 | 0 | 3 |
| NEK11 | GPR158 | 0.705292 | 3 | 0 | 3 |
| NEK11 | GGA3 | 0.702437 | 3 | 0 | 3 |
| NEK11 | HSDL1 | 0.699843 | 3 | 0 | 3 |
| NEK11 | SAG | 0.698154 | 3 | 0 | 3 |
| NEK11 | TRMT12 | 0.693395 | 3 | 0 | 3 |
| NEK11 | TBC1D23 | 0.691842 | 3 | 0 | 3 |
| NEK11 | KIAA0895 | 0.691266 | 3 | 0 | 3 |
| NEK11 | E2F4 | 0.684776 | 3 | 0 | 3 |
| NEK11 | SPNS1 | 0.684593 | 3 | 0 | 3 |
| NEK11 | ZNF717 | 0.683665 | 3 | 0 | 3 |
| NEK11 | SERINC3 | 0.682712 | 5 | 0 | 4 |
| NEK11 | PSME1 | 0.670275 | 3 | 0 | 3 |
For details and further investigation, click here
