| Full name: MYST/Esa1 associated factor 6 | Alias Symbol: NY-SAR-91|FLJ11730|Eaf6|CENP-28 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 64769 | HGNC ID: HGNC:25674 | Ensembl Gene: ENSG00000163875 | OMIM ID: 611001 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MEAF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEAF6 | 64769 | 218165_at | 0.0435 | 0.9484 | |
| GSE20347 | MEAF6 | 64769 | 218165_at | 0.0614 | 0.6968 | |
| GSE23400 | MEAF6 | 64769 | 218165_at | 0.1694 | 0.0017 | |
| GSE26886 | MEAF6 | 64769 | 218165_at | -0.4126 | 0.0194 | |
| GSE29001 | MEAF6 | 64769 | 218165_at | -0.0611 | 0.7817 | |
| GSE38129 | MEAF6 | 64769 | 218165_at | 0.0414 | 0.7201 | |
| GSE45670 | MEAF6 | 64769 | 218165_at | -0.1828 | 0.0565 | |
| GSE53622 | MEAF6 | 64769 | 104039 | 0.0087 | 0.8804 | |
| GSE53624 | MEAF6 | 64769 | 104039 | 0.1346 | 0.0207 | |
| GSE63941 | MEAF6 | 64769 | 218165_at | -0.3115 | 0.3389 | |
| GSE77861 | MEAF6 | 64769 | 218165_at | -0.0960 | 0.6705 | |
| GSE97050 | MEAF6 | 64769 | A_24_P268015 | -0.0212 | 0.9537 | |
| SRP007169 | MEAF6 | 64769 | RNAseq | -0.6577 | 0.1023 | |
| SRP008496 | MEAF6 | 64769 | RNAseq | -0.5645 | 0.0101 | |
| SRP064894 | MEAF6 | 64769 | RNAseq | -0.0944 | 0.4518 | |
| SRP133303 | MEAF6 | 64769 | RNAseq | 0.0819 | 0.5113 | |
| SRP159526 | MEAF6 | 64769 | RNAseq | 0.0228 | 0.9209 | |
| SRP193095 | MEAF6 | 64769 | RNAseq | -0.0947 | 0.2431 | |
| SRP219564 | MEAF6 | 64769 | RNAseq | 0.1223 | 0.7062 | |
| TCGA | MEAF6 | 64769 | RNAseq | 0.0627 | 0.1994 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MEAF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MEAF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEAF6 | 64769 | 2 | 4 | 24 | |
| GSE20123 | MEAF6 | 64769 | 2 | 3 | 25 | |
| GSE43470 | MEAF6 | 64769 | 7 | 3 | 33 | |
| GSE46452 | MEAF6 | 64769 | 4 | 1 | 54 | |
| GSE47630 | MEAF6 | 64769 | 8 | 3 | 29 | |
| GSE54993 | MEAF6 | 64769 | 1 | 1 | 68 | |
| GSE54994 | MEAF6 | 64769 | 11 | 2 | 40 | |
| GSE60625 | MEAF6 | 64769 | 0 | 0 | 11 | |
| GSE74703 | MEAF6 | 64769 | 6 | 2 | 28 | |
| GSE74704 | MEAF6 | 64769 | 1 | 0 | 19 | |
| TCGA | MEAF6 | 64769 | 12 | 16 | 68 |
Total number of gains: 54; Total number of losses: 35; Total Number of normals: 399.
Somatic mutations of MEAF6:
Generating mutation plots.
Highly correlated genes for MEAF6:
Showing top 20/243 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEAF6 | NSD1 | 0.780509 | 3 | 0 | 3 |
| MEAF6 | CHCHD6 | 0.780337 | 3 | 0 | 3 |
| MEAF6 | MYSM1 | 0.773343 | 3 | 0 | 3 |
| MEAF6 | WBP2 | 0.77008 | 3 | 0 | 3 |
| MEAF6 | SPRYD4 | 0.759194 | 3 | 0 | 3 |
| MEAF6 | PEPD | 0.733606 | 3 | 0 | 3 |
| MEAF6 | PDK2 | 0.727794 | 3 | 0 | 3 |
| MEAF6 | PALM | 0.726335 | 3 | 0 | 3 |
| MEAF6 | SRP68 | 0.722663 | 3 | 0 | 3 |
| MEAF6 | UBE4B | 0.722435 | 4 | 0 | 4 |
| MEAF6 | NACC2 | 0.716595 | 3 | 0 | 3 |
| MEAF6 | CLK3 | 0.716065 | 3 | 0 | 3 |
| MEAF6 | UBR4 | 0.715649 | 3 | 0 | 3 |
| MEAF6 | NDUFA13 | 0.712428 | 4 | 0 | 4 |
| MEAF6 | SLC25A39 | 0.710109 | 3 | 0 | 3 |
| MEAF6 | C6orf120 | 0.706848 | 3 | 0 | 3 |
| MEAF6 | GLUD1 | 0.702054 | 4 | 0 | 3 |
| MEAF6 | PPP4R1 | 0.698826 | 3 | 0 | 3 |
| MEAF6 | PRPF38A | 0.697496 | 4 | 0 | 3 |
| MEAF6 | AGAP1 | 0.693244 | 4 | 0 | 3 |
For details and further investigation, click here
