| Full name: melanocortin 1 receptor | Alias Symbol: MSH-R | ||
| Type: protein-coding gene | Cytoband: 16q24.3 | ||
| Entrez ID: 4157 | HGNC ID: HGNC:6929 | Ensembl Gene: ENSG00000258839 | OMIM ID: 155555 |
| Drug and gene relationship at DGIdb | |||
MC1R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04916 | Melanogenesis |
Expression of MC1R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MC1R | 4157 | 205458_at | 0.2034 | 0.3905 | |
| GSE20347 | MC1R | 4157 | 205458_at | 0.2367 | 0.0222 | |
| GSE23400 | MC1R | 4157 | 205458_at | 0.0089 | 0.8768 | |
| GSE26886 | MC1R | 4157 | 205458_at | 0.4357 | 0.0027 | |
| GSE29001 | MC1R | 4157 | 205458_at | 0.1668 | 0.4404 | |
| GSE38129 | MC1R | 4157 | 205458_at | 0.3174 | 0.0008 | |
| GSE45670 | MC1R | 4157 | 205458_at | 0.2892 | 0.0303 | |
| GSE53622 | MC1R | 4157 | 94321 | 0.6619 | 0.0000 | |
| GSE53624 | MC1R | 4157 | 94321 | 0.9960 | 0.0000 | |
| GSE63941 | MC1R | 4157 | 205458_at | 0.2911 | 0.1894 | |
| GSE77861 | MC1R | 4157 | 205458_at | 0.2356 | 0.1526 | |
| GSE97050 | MC1R | 4157 | A_33_P3352767 | 0.4203 | 0.1782 | |
| SRP007169 | MC1R | 4157 | RNAseq | 1.8585 | 0.1070 | |
| SRP064894 | MC1R | 4157 | RNAseq | 2.3530 | 0.0000 | |
| SRP133303 | MC1R | 4157 | RNAseq | 1.5846 | 0.0000 | |
| SRP159526 | MC1R | 4157 | RNAseq | 1.7679 | 0.0000 | |
| SRP193095 | MC1R | 4157 | RNAseq | 1.7388 | 0.0000 | |
| SRP219564 | MC1R | 4157 | RNAseq | 0.9772 | 0.0218 | |
| TCGA | MC1R | 4157 | RNAseq | 0.4477 | 0.0011 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by MC1R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MC1R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MC1R | 4157 | 4 | 3 | 23 | |
| GSE20123 | MC1R | 4157 | 4 | 3 | 23 | |
| GSE43470 | MC1R | 4157 | 1 | 13 | 29 | |
| GSE46452 | MC1R | 4157 | 38 | 1 | 20 | |
| GSE47630 | MC1R | 4157 | 11 | 9 | 20 | |
| GSE54993 | MC1R | 4157 | 3 | 4 | 63 | |
| GSE54994 | MC1R | 4157 | 9 | 11 | 33 | |
| GSE60625 | MC1R | 4157 | 4 | 0 | 7 | |
| GSE74703 | MC1R | 4157 | 1 | 9 | 26 | |
| GSE74704 | MC1R | 4157 | 3 | 1 | 16 | |
| TCGA | MC1R | 4157 | 26 | 15 | 55 |
Total number of gains: 104; Total number of losses: 69; Total Number of normals: 315.
Somatic mutations of MC1R:
Generating mutation plots.
Highly correlated genes for MC1R:
Showing top 20/627 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MC1R | DEFB121 | 0.775943 | 3 | 0 | 3 |
| MC1R | MS4A18 | 0.763206 | 3 | 0 | 3 |
| MC1R | LHB | 0.747823 | 3 | 0 | 3 |
| MC1R | FAM181A | 0.737135 | 3 | 0 | 3 |
| MC1R | MRGPRG | 0.736626 | 3 | 0 | 3 |
| MC1R | IFITM5 | 0.736223 | 3 | 0 | 3 |
| MC1R | KIF19 | 0.722836 | 3 | 0 | 3 |
| MC1R | SUN5 | 0.720309 | 3 | 0 | 3 |
| MC1R | C15orf40 | 0.716792 | 3 | 0 | 3 |
| MC1R | PRAMEF5 | 0.707905 | 3 | 0 | 3 |
| MC1R | NPBWR1 | 0.697941 | 4 | 0 | 4 |
| MC1R | ELOVL3 | 0.69343 | 4 | 0 | 3 |
| MC1R | FUZ | 0.690071 | 3 | 0 | 3 |
| MC1R | OR2A5 | 0.689811 | 3 | 0 | 3 |
| MC1R | ANKRD52 | 0.685906 | 5 | 0 | 5 |
| MC1R | NUBP2 | 0.685069 | 4 | 0 | 4 |
| MC1R | C2orf81 | 0.682141 | 4 | 0 | 4 |
| MC1R | CDRT15 | 0.681274 | 4 | 0 | 4 |
| MC1R | GPR150 | 0.678075 | 3 | 0 | 3 |
| MC1R | NTNG2 | 0.678005 | 4 | 0 | 4 |
For details and further investigation, click here
