| Full name: MCF.2 cell line derived transforming sequence-like 2 | Alias Symbol: KIAA0861|ARHGEF22 | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 23101 | HGNC ID: HGNC:30319 | Ensembl Gene: ENSG00000053524 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of MCF2L2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCF2L2 | 23101 | 215112_x_at | 0.0773 | 0.7415 | |
| GSE20347 | MCF2L2 | 23101 | 215112_x_at | 0.0676 | 0.1643 | |
| GSE23400 | MCF2L2 | 23101 | 215112_x_at | 0.0076 | 0.5044 | |
| GSE26886 | MCF2L2 | 23101 | 215112_x_at | 0.0568 | 0.5725 | |
| GSE29001 | MCF2L2 | 23101 | 215112_x_at | 0.0408 | 0.7058 | |
| GSE38129 | MCF2L2 | 23101 | 215112_x_at | 0.0834 | 0.0264 | |
| GSE45670 | MCF2L2 | 23101 | 215112_x_at | 0.0538 | 0.3634 | |
| GSE53622 | MCF2L2 | 23101 | 53761 | 0.4783 | 0.0000 | |
| GSE53624 | MCF2L2 | 23101 | 53761 | 0.2167 | 0.0130 | |
| GSE63941 | MCF2L2 | 23101 | 215112_x_at | -0.0513 | 0.7158 | |
| GSE77861 | MCF2L2 | 23101 | 215112_x_at | 0.0232 | 0.7247 | |
| SRP064894 | MCF2L2 | 23101 | RNAseq | 0.3967 | 0.1917 | |
| SRP133303 | MCF2L2 | 23101 | RNAseq | 0.3798 | 0.0444 | |
| SRP159526 | MCF2L2 | 23101 | RNAseq | 1.1978 | 0.0003 | |
| SRP193095 | MCF2L2 | 23101 | RNAseq | 0.4840 | 0.0044 | |
| SRP219564 | MCF2L2 | 23101 | RNAseq | 0.6611 | 0.1530 | |
| TCGA | MCF2L2 | 23101 | RNAseq | 0.7654 | 0.0002 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by MCF2L2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MCF2L2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCF2L2 | 23101 | 25 | 0 | 5 | |
| GSE20123 | MCF2L2 | 23101 | 25 | 0 | 5 | |
| GSE43470 | MCF2L2 | 23101 | 24 | 0 | 19 | |
| GSE46452 | MCF2L2 | 23101 | 19 | 1 | 39 | |
| GSE47630 | MCF2L2 | 23101 | 27 | 2 | 11 | |
| GSE54993 | MCF2L2 | 23101 | 1 | 19 | 50 | |
| GSE54994 | MCF2L2 | 23101 | 41 | 0 | 12 | |
| GSE60625 | MCF2L2 | 23101 | 0 | 6 | 5 | |
| GSE74703 | MCF2L2 | 23101 | 20 | 0 | 16 | |
| GSE74704 | MCF2L2 | 23101 | 17 | 0 | 3 | |
| TCGA | MCF2L2 | 23101 | 77 | 0 | 19 |
Total number of gains: 276; Total number of losses: 28; Total Number of normals: 184.
Somatic mutations of MCF2L2:
Generating mutation plots.
Highly correlated genes for MCF2L2:
Showing all 16 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCF2L2 | SASH3 | 0.588277 | 3 | 0 | 3 |
| MCF2L2 | LILRA4 | 0.584342 | 3 | 0 | 3 |
| MCF2L2 | OPA3 | 0.580214 | 4 | 0 | 3 |
| MCF2L2 | LIN28A | 0.56658 | 5 | 0 | 3 |
| MCF2L2 | SH2D4B | 0.565706 | 3 | 0 | 3 |
| MCF2L2 | EMC10 | 0.554642 | 4 | 0 | 3 |
| MCF2L2 | BAIAP2L1 | 0.553055 | 3 | 0 | 3 |
| MCF2L2 | ANAPC2 | 0.551236 | 3 | 0 | 3 |
| MCF2L2 | SF3A2 | 0.544006 | 4 | 0 | 3 |
| MCF2L2 | APOF | 0.537246 | 5 | 0 | 4 |
| MCF2L2 | GMEB2 | 0.530361 | 4 | 0 | 3 |
| MCF2L2 | HAUS5 | 0.523926 | 5 | 0 | 3 |
| MCF2L2 | JUND | 0.518126 | 3 | 0 | 3 |
| MCF2L2 | TBX19 | 0.51527 | 5 | 0 | 3 |
| MCF2L2 | KHSRP | 0.509407 | 4 | 0 | 3 |
| MCF2L2 | HIVEP2 | 0.507601 | 4 | 0 | 3 |
For details and further investigation, click here
