| Full name: splicing factor 3a subunit 2 | Alias Symbol: SF3a66|SAP62|PRPF11|Prp11 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 8175 | HGNC ID: HGNC:10766 | Ensembl Gene: ENSG00000104897 | OMIM ID: 600796 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SF3A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SF3A2 | 8175 | 37462_i_at | 0.3575 | 0.2951 | |
| GSE20347 | SF3A2 | 8175 | 37462_i_at | 0.1584 | 0.3374 | |
| GSE23400 | SF3A2 | 8175 | 37462_i_at | 0.5371 | 0.0000 | |
| GSE26886 | SF3A2 | 8175 | 37462_i_at | 1.4066 | 0.0000 | |
| GSE29001 | SF3A2 | 8175 | 37462_i_at | 0.0392 | 0.9677 | |
| GSE38129 | SF3A2 | 8175 | 37462_i_at | 0.3508 | 0.0231 | |
| GSE45670 | SF3A2 | 8175 | 37462_i_at | 0.2198 | 0.0329 | |
| GSE53622 | SF3A2 | 8175 | 143780 | 0.3524 | 0.0000 | |
| GSE53624 | SF3A2 | 8175 | 143780 | 0.6939 | 0.0000 | |
| GSE63941 | SF3A2 | 8175 | 37462_i_at | 0.3105 | 0.3779 | |
| GSE77861 | SF3A2 | 8175 | 209381_x_at | 0.3704 | 0.3363 | |
| GSE97050 | SF3A2 | 8175 | A_33_P3210079 | 0.1376 | 0.5391 | |
| SRP007169 | SF3A2 | 8175 | RNAseq | 0.5082 | 0.3422 | |
| SRP008496 | SF3A2 | 8175 | RNAseq | 0.5641 | 0.1746 | |
| SRP064894 | SF3A2 | 8175 | RNAseq | 0.6336 | 0.0067 | |
| SRP133303 | SF3A2 | 8175 | RNAseq | 0.2821 | 0.1069 | |
| SRP159526 | SF3A2 | 8175 | RNAseq | 0.3330 | 0.1659 | |
| SRP193095 | SF3A2 | 8175 | RNAseq | 0.4195 | 0.0043 | |
| SRP219564 | SF3A2 | 8175 | RNAseq | 0.5640 | 0.0373 | |
| TCGA | SF3A2 | 8175 | RNAseq | 0.2503 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SF3A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SF3A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SF3A2 | 8175 | 4 | 6 | 20 | |
| GSE20123 | SF3A2 | 8175 | 4 | 5 | 21 | |
| GSE43470 | SF3A2 | 8175 | 1 | 10 | 32 | |
| GSE46452 | SF3A2 | 8175 | 47 | 1 | 11 | |
| GSE47630 | SF3A2 | 8175 | 5 | 7 | 28 | |
| GSE54993 | SF3A2 | 8175 | 16 | 3 | 51 | |
| GSE54994 | SF3A2 | 8175 | 8 | 15 | 30 | |
| GSE60625 | SF3A2 | 8175 | 9 | 0 | 2 | |
| GSE74703 | SF3A2 | 8175 | 1 | 7 | 28 | |
| GSE74704 | SF3A2 | 8175 | 3 | 3 | 14 | |
| TCGA | SF3A2 | 8175 | 7 | 24 | 65 |
Total number of gains: 105; Total number of losses: 81; Total Number of normals: 302.
Somatic mutations of SF3A2:
Generating mutation plots.
Highly correlated genes for SF3A2:
Showing top 20/1028 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SF3A2 | RNASEH2C | 0.824729 | 3 | 0 | 3 |
| SF3A2 | SGSH | 0.811726 | 3 | 0 | 3 |
| SF3A2 | ZNF451 | 0.807068 | 3 | 0 | 3 |
| SF3A2 | SPTAN1 | 0.793833 | 3 | 0 | 3 |
| SF3A2 | SZT2 | 0.777415 | 4 | 0 | 4 |
| SF3A2 | SLC25A29 | 0.774274 | 3 | 0 | 3 |
| SF3A2 | ANKRD11 | 0.76736 | 3 | 0 | 3 |
| SF3A2 | EVI5L | 0.766259 | 4 | 0 | 4 |
| SF3A2 | HIP1 | 0.76121 | 4 | 0 | 4 |
| SF3A2 | SPIRE1 | 0.753897 | 3 | 0 | 3 |
| SF3A2 | ZNF628 | 0.743236 | 5 | 0 | 5 |
| SF3A2 | COL17A1 | 0.742148 | 3 | 0 | 3 |
| SF3A2 | SLC39A3 | 0.738467 | 4 | 0 | 3 |
| SF3A2 | LGI2 | 0.737536 | 3 | 0 | 3 |
| SF3A2 | SNTA1 | 0.736399 | 5 | 0 | 5 |
| SF3A2 | SCNM1 | 0.728577 | 3 | 0 | 3 |
| SF3A2 | CCDC124 | 0.726001 | 3 | 0 | 3 |
| SF3A2 | PRR12 | 0.724635 | 4 | 0 | 4 |
| SF3A2 | PIP5K1C | 0.724511 | 5 | 0 | 5 |
| SF3A2 | NUP43 | 0.723362 | 5 | 0 | 4 |
For details and further investigation, click here
