| Full name: outer mitochondrial membrane lipid metabolism regulator OPA3 | Alias Symbol: FLJ22187|MGA3 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 80207 | HGNC ID: HGNC:8142 | Ensembl Gene: ENSG00000125741 | OMIM ID: 606580 |
| Drug and gene relationship at DGIdb | |||
Expression of OPA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OPA3 | 80207 | 229624_at | 0.2751 | 0.3180 | |
| GSE20347 | OPA3 | 80207 | 206357_at | -0.2497 | 0.0078 | |
| GSE23400 | OPA3 | 80207 | 206357_at | -0.1083 | 0.0009 | |
| GSE26886 | OPA3 | 80207 | 229624_at | 0.2079 | 0.2293 | |
| GSE29001 | OPA3 | 80207 | 206357_at | 0.2589 | 0.2445 | |
| GSE38129 | OPA3 | 80207 | 206357_at | -0.0331 | 0.7979 | |
| GSE45670 | OPA3 | 80207 | 229624_at | 0.2505 | 0.0119 | |
| GSE53622 | OPA3 | 80207 | 77837 | -0.4037 | 0.0078 | |
| GSE53624 | OPA3 | 80207 | 77837 | 0.0390 | 0.7393 | |
| GSE63941 | OPA3 | 80207 | 229624_at | -0.4307 | 0.0459 | |
| GSE77861 | OPA3 | 80207 | 229624_at | -0.0269 | 0.7933 | |
| GSE97050 | OPA3 | 80207 | A_24_P475814 | -0.0864 | 0.6542 | |
| SRP007169 | OPA3 | 80207 | RNAseq | 0.3245 | 0.4008 | |
| SRP008496 | OPA3 | 80207 | RNAseq | 0.0446 | 0.8572 | |
| SRP064894 | OPA3 | 80207 | RNAseq | 0.4111 | 0.0005 | |
| SRP133303 | OPA3 | 80207 | RNAseq | 0.0715 | 0.4715 | |
| SRP159526 | OPA3 | 80207 | RNAseq | 0.1052 | 0.4623 | |
| SRP193095 | OPA3 | 80207 | RNAseq | 0.1399 | 0.1375 | |
| SRP219564 | OPA3 | 80207 | RNAseq | 0.2389 | 0.4066 | |
| TCGA | OPA3 | 80207 | RNAseq | -0.0889 | 0.0813 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by OPA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OPA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OPA3 | 80207 | 4 | 5 | 21 | |
| GSE20123 | OPA3 | 80207 | 4 | 4 | 22 | |
| GSE43470 | OPA3 | 80207 | 3 | 11 | 29 | |
| GSE46452 | OPA3 | 80207 | 45 | 1 | 13 | |
| GSE47630 | OPA3 | 80207 | 8 | 7 | 25 | |
| GSE54993 | OPA3 | 80207 | 17 | 4 | 49 | |
| GSE54994 | OPA3 | 80207 | 6 | 12 | 35 | |
| GSE60625 | OPA3 | 80207 | 9 | 0 | 2 | |
| GSE74703 | OPA3 | 80207 | 3 | 7 | 26 | |
| GSE74704 | OPA3 | 80207 | 4 | 2 | 14 | |
| TCGA | OPA3 | 80207 | 15 | 16 | 65 |
Total number of gains: 118; Total number of losses: 69; Total Number of normals: 301.
Somatic mutations of OPA3:
Generating mutation plots.
Highly correlated genes for OPA3:
Showing top 20/41 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OPA3 | C1orf53 | 0.703622 | 3 | 0 | 3 |
| OPA3 | COL27A1 | 0.6543 | 3 | 0 | 3 |
| OPA3 | MAPKAPK2 | 0.629696 | 3 | 0 | 3 |
| OPA3 | IL18BP | 0.627783 | 4 | 0 | 3 |
| OPA3 | ZFYVE26 | 0.626768 | 3 | 0 | 3 |
| OPA3 | WDR25 | 0.625033 | 3 | 0 | 3 |
| OPA3 | YY1 | 0.622276 | 4 | 0 | 3 |
| OPA3 | TWIST2 | 0.620327 | 3 | 0 | 3 |
| OPA3 | PBX4 | 0.614836 | 4 | 0 | 3 |
| OPA3 | TMEM151B | 0.604944 | 3 | 0 | 3 |
| OPA3 | TFPT | 0.591832 | 4 | 0 | 3 |
| OPA3 | LRRC6 | 0.588038 | 4 | 0 | 3 |
| OPA3 | VGF | 0.586814 | 3 | 0 | 3 |
| OPA3 | ZBTB49 | 0.582936 | 3 | 0 | 3 |
| OPA3 | MCF2L2 | 0.580214 | 4 | 0 | 3 |
| OPA3 | SFXN5 | 0.575914 | 5 | 0 | 4 |
| OPA3 | CDC34 | 0.57336 | 3 | 0 | 3 |
| OPA3 | CYTH2 | 0.566633 | 4 | 0 | 3 |
| OPA3 | S1PR2 | 0.565615 | 4 | 0 | 3 |
| OPA3 | USP46-AS1 | 0.563395 | 3 | 0 | 3 |
For details and further investigation, click here
