| Full name: SH2 domain containing 4B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q23.1 | ||
| Entrez ID: 387694 | HGNC ID: HGNC:31440 | Ensembl Gene: ENSG00000178217 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of SH2D4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH2D4B | 387694 | 1563849_at | 0.0745 | 0.7188 | |
| GSE26886 | SH2D4B | 387694 | 1563849_at | 0.1114 | 0.3824 | |
| GSE45670 | SH2D4B | 387694 | 1563849_at | 0.0769 | 0.3655 | |
| GSE53622 | SH2D4B | 387694 | 59954 | -0.4166 | 0.0005 | |
| GSE53624 | SH2D4B | 387694 | 59954 | -0.3533 | 0.0003 | |
| GSE63941 | SH2D4B | 387694 | 1563849_at | -0.0352 | 0.7820 | |
| GSE77861 | SH2D4B | 387694 | 1563849_at | 0.0021 | 0.9877 | |
| GSE97050 | SH2D4B | 387694 | A_33_P3319856 | -0.7019 | 0.1972 | |
| TCGA | SH2D4B | 387694 | RNAseq | 4.1670 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by SH2D4B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH2D4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH2D4B | 387694 | 2 | 4 | 24 | |
| GSE20123 | SH2D4B | 387694 | 2 | 3 | 25 | |
| GSE43470 | SH2D4B | 387694 | 1 | 7 | 35 | |
| GSE46452 | SH2D4B | 387694 | 0 | 11 | 48 | |
| GSE47630 | SH2D4B | 387694 | 2 | 14 | 24 | |
| GSE54993 | SH2D4B | 387694 | 7 | 0 | 63 | |
| GSE54994 | SH2D4B | 387694 | 1 | 12 | 40 | |
| GSE60625 | SH2D4B | 387694 | 0 | 0 | 11 | |
| GSE74703 | SH2D4B | 387694 | 1 | 4 | 31 | |
| GSE74704 | SH2D4B | 387694 | 1 | 1 | 18 | |
| TCGA | SH2D4B | 387694 | 10 | 24 | 62 |
Total number of gains: 27; Total number of losses: 80; Total Number of normals: 381.
Somatic mutations of SH2D4B:
Generating mutation plots.
Highly correlated genes for SH2D4B:
Showing top 20/49 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH2D4B | C9orf106 | 0.713187 | 3 | 0 | 3 |
| SH2D4B | MFSD2B | 0.713097 | 3 | 0 | 3 |
| SH2D4B | ZNF569 | 0.692171 | 3 | 0 | 3 |
| SH2D4B | TSNAXIP1 | 0.675963 | 3 | 0 | 3 |
| SH2D4B | KRTAP6-1 | 0.663465 | 3 | 0 | 3 |
| SH2D4B | EFNA4 | 0.649967 | 3 | 0 | 3 |
| SH2D4B | PROCA1 | 0.6466 | 3 | 0 | 3 |
| SH2D4B | PLEC | 0.645885 | 3 | 0 | 3 |
| SH2D4B | WDR62 | 0.643049 | 3 | 0 | 3 |
| SH2D4B | RHBDD3 | 0.634253 | 3 | 0 | 3 |
| SH2D4B | ESRRA | 0.633435 | 4 | 0 | 3 |
| SH2D4B | DRD3 | 0.632157 | 3 | 0 | 3 |
| SH2D4B | PGP | 0.631195 | 3 | 0 | 3 |
| SH2D4B | ABCA7 | 0.624895 | 5 | 0 | 4 |
| SH2D4B | TRPS1 | 0.624729 | 3 | 0 | 3 |
| SH2D4B | GRM1 | 0.623416 | 3 | 0 | 3 |
| SH2D4B | CPNE9 | 0.619317 | 3 | 0 | 3 |
| SH2D4B | PRDM16 | 0.602408 | 3 | 0 | 3 |
| SH2D4B | DUOXA2 | 0.601422 | 4 | 0 | 3 |
| SH2D4B | PRKAR1B | 0.598176 | 4 | 0 | 3 |
For details and further investigation, click here
