| Full name: microcephalin 1 | Alias Symbol: FLJ12847|BRIT1 | ||
| Type: protein-coding gene | Cytoband: 8p23.1 | ||
| Entrez ID: 79648 | HGNC ID: HGNC:6954 | Ensembl Gene: ENSG00000147316 | OMIM ID: 607117 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MCPH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MCPH1 | 79648 | 1554155_at | 0.1875 | 0.7213 | |
| GSE20347 | MCPH1 | 79648 | 219592_at | 0.0005 | 0.9964 | |
| GSE23400 | MCPH1 | 79648 | 219592_at | -0.0272 | 0.4536 | |
| GSE26886 | MCPH1 | 79648 | 228778_at | -0.6166 | 0.0480 | |
| GSE29001 | MCPH1 | 79648 | 219592_at | 0.0810 | 0.7037 | |
| GSE38129 | MCPH1 | 79648 | 219592_at | 0.0471 | 0.5136 | |
| GSE45670 | MCPH1 | 79648 | 1557347_at | 0.0493 | 0.7416 | |
| GSE63941 | MCPH1 | 79648 | 1554155_at | -0.0092 | 0.9894 | |
| GSE77861 | MCPH1 | 79648 | 1557347_at | 0.0968 | 0.6530 | |
| GSE97050 | MCPH1 | A_21_P0000200 | -0.0518 | 0.8625 | ||
| SRP007169 | MCPH1 | 79648 | RNAseq | -0.0051 | 0.9902 | |
| SRP008496 | MCPH1 | 79648 | RNAseq | 0.2326 | 0.3284 | |
| SRP064894 | MCPH1 | 79648 | RNAseq | -0.0096 | 0.9529 | |
| SRP133303 | MCPH1 | 79648 | RNAseq | -0.0751 | 0.6678 | |
| SRP159526 | MCPH1 | 79648 | RNAseq | -0.2368 | 0.2683 | |
| SRP193095 | MCPH1 | 79648 | RNAseq | -0.1715 | 0.1253 | |
| SRP219564 | MCPH1 | 79648 | RNAseq | 0.0805 | 0.6392 | |
| TCGA | MCPH1 | 79648 | RNAseq | -0.0795 | 0.1668 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MCPH1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MCPH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MCPH1 | 79648 | 4 | 11 | 15 | |
| GSE20123 | MCPH1 | 79648 | 4 | 11 | 15 | |
| GSE43470 | MCPH1 | 79648 | 4 | 10 | 29 | |
| GSE46452 | MCPH1 | 79648 | 12 | 14 | 33 | |
| GSE47630 | MCPH1 | 79648 | 9 | 7 | 24 | |
| GSE54993 | MCPH1 | 79648 | 3 | 14 | 53 | |
| GSE54994 | MCPH1 | 79648 | 9 | 19 | 25 | |
| GSE60625 | MCPH1 | 79648 | 3 | 0 | 8 | |
| GSE74703 | MCPH1 | 79648 | 4 | 8 | 24 | |
| GSE74704 | MCPH1 | 79648 | 3 | 7 | 10 | |
| TCGA | MCPH1 | 79648 | 13 | 40 | 43 |
Total number of gains: 68; Total number of losses: 141; Total Number of normals: 279.
Somatic mutations of MCPH1:
Generating mutation plots.
Highly correlated genes for MCPH1:
Showing top 20/146 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MCPH1 | DHX40 | 0.843733 | 3 | 0 | 3 |
| MCPH1 | RNF138 | 0.830483 | 3 | 0 | 3 |
| MCPH1 | PMPCB | 0.817565 | 3 | 0 | 3 |
| MCPH1 | LIPT1 | 0.775652 | 3 | 0 | 3 |
| MCPH1 | CEP44 | 0.76607 | 3 | 0 | 3 |
| MCPH1 | ZNHIT3 | 0.760598 | 3 | 0 | 3 |
| MCPH1 | GALNT7 | 0.755896 | 3 | 0 | 3 |
| MCPH1 | SS18 | 0.748292 | 3 | 0 | 3 |
| MCPH1 | C5orf51 | 0.746587 | 4 | 0 | 4 |
| MCPH1 | GLYR1 | 0.74109 | 3 | 0 | 3 |
| MCPH1 | ZFAND1 | 0.739298 | 3 | 0 | 3 |
| MCPH1 | PIGA | 0.737138 | 3 | 0 | 3 |
| MCPH1 | STAMBPL1 | 0.734341 | 3 | 0 | 3 |
| MCPH1 | NFXL1 | 0.731477 | 3 | 0 | 3 |
| MCPH1 | ZRANB2 | 0.729872 | 3 | 0 | 3 |
| MCPH1 | ZNF805 | 0.729378 | 3 | 0 | 3 |
| MCPH1 | ZCCHC2 | 0.729296 | 3 | 0 | 3 |
| MCPH1 | SMAD2 | 0.728661 | 3 | 0 | 3 |
| MCPH1 | NUP54 | 0.722319 | 3 | 0 | 3 |
| MCPH1 | MAP4K3 | 0.721091 | 3 | 0 | 3 |
For details and further investigation, click here
