SMAD2

 

Full name: SMAD family member 2 Alias Symbol: MADR2|JV18-1
Type: protein-coding gene Cytoband: 18q21.1
Entrez ID: 4087 HGNC ID: HGNC:6768 Ensembl Gene: ENSG00000175387 OMIM ID: 601366
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 4/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

SMAD2 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04520Adherens junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05142Chagas disease (American trypanosomiasis)
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05321Inflammatory bowel disease (IBD)

 

Expression of SMAD2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SMAD2 4087 203075_at -0.2754 0.5905
GSE20347 SMAD2 4087 203075_at -0.1299 0.4374
GSE23400 SMAD2 4087 203076_s_at 0.1416 0.0072
GSE26886 SMAD2 4087 203075_at -0.3134 0.0721
GSE29001 SMAD2 4087 203075_at 0.2672 0.2213
GSE38129 SMAD2 4087 203075_at -0.1632 0.2235
GSE45670 SMAD2 4087 203076_s_at -0.1671 0.1727
GSE53622 SMAD2 4087 5428 1.8659 0.0000
GSE53624 SMAD2 4087 5428 1.7218 0.0000
GSE63941 SMAD2 4087 203076_s_at 0.0085 0.9894
GSE77861 SMAD2 4087 203076_s_at 0.1654 0.5547
GSE97050 SMAD2 4087 A_32_P12580 -0.0976 0.6233
SRP007169 SMAD2 4087 RNAseq -0.3876 0.2200
SRP008496 SMAD2 4087 RNAseq 0.4366 0.2490
SRP064894 SMAD2 4087 RNAseq 0.0619 0.6128
SRP133303 SMAD2 4087 RNAseq -0.0074 0.9668
SRP159526 SMAD2 4087 RNAseq 0.1999 0.5604
SRP193095 SMAD2 4087 RNAseq -0.1216 0.2208
SRP219564 SMAD2 4087 RNAseq -0.2086 0.3474
TCGA SMAD2 4087 RNAseq -0.0347 0.4839

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by SMAD2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SMAD2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SMAD2 4087 1 8 21
GSE20123 SMAD2 4087 1 8 21
GSE43470 SMAD2 4087 0 5 38
GSE46452 SMAD2 4087 1 26 32
GSE47630 SMAD2 4087 5 20 15
GSE54993 SMAD2 4087 8 1 61
GSE54994 SMAD2 4087 2 16 35
GSE60625 SMAD2 4087 0 4 7
GSE74703 SMAD2 4087 0 4 32
GSE74704 SMAD2 4087 0 6 14
TCGA SMAD2 4087 13 41 42

Total number of gains: 31; Total number of losses: 139; Total Number of normals: 318.  

 

Somatic mutations of SMAD2:

 

Generating mutation plots.

 

Highly correlated genes for SMAD2:

 

Showing top 20/231 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SMAD2BEX50.832545303
SMAD2ASB30.758228303
SMAD2ALG110.752827303
SMAD2CMTM60.741189303
SMAD2EIF3J0.735957303
SMAD2MCPH10.728661303
SMAD2SPDYE30.715708303
SMAD2TIMM210.713541303
SMAD2DTWD10.698457303
SMAD2SUMO30.694999403
SMAD2MCM80.694969303
SMAD2MPHOSPH90.694564404
SMAD2AATF0.693819303
SMAD2NUB10.690087303
SMAD2SIX40.687892303
SMAD2C1orf1220.682787303
SMAD2FUBP10.680422303
SMAD2INPP5B0.678956303
SMAD2STXBP40.676114303
SMAD2SCNM10.675672303

For details and further investigation, click here