| Full name: mitogen-activated protein kinase kinase kinase kinase 3 | Alias Symbol: GLK|MAPKKKK3 | ||
| Type: protein-coding gene | Cytoband: 2p22.1 | ||
| Entrez ID: 8491 | HGNC ID: HGNC:6865 | Ensembl Gene: ENSG00000011566 | OMIM ID: 604921 |
| Drug and gene relationship at DGIdb | |||
MAP4K3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of MAP4K3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP4K3 | 8491 | 218311_at | 0.0555 | 0.8911 | |
| GSE20347 | MAP4K3 | 8491 | 218311_at | 0.2430 | 0.1632 | |
| GSE23400 | MAP4K3 | 8491 | 218311_at | 0.3420 | 0.0001 | |
| GSE26886 | MAP4K3 | 8491 | 218311_at | -0.2903 | 0.4974 | |
| GSE29001 | MAP4K3 | 8491 | 218311_at | 0.2359 | 0.6067 | |
| GSE38129 | MAP4K3 | 8491 | 218311_at | 0.1868 | 0.1425 | |
| GSE45670 | MAP4K3 | 8491 | 218311_at | -0.1643 | 0.2781 | |
| GSE53622 | MAP4K3 | 8491 | 39849 | 0.1967 | 0.0505 | |
| GSE53624 | MAP4K3 | 8491 | 39849 | 0.0440 | 0.7151 | |
| GSE63941 | MAP4K3 | 8491 | 218311_at | -1.8380 | 0.0010 | |
| GSE77861 | MAP4K3 | 8491 | 218311_at | 0.7407 | 0.0458 | |
| GSE97050 | MAP4K3 | 8491 | A_24_P285522 | -0.1556 | 0.6965 | |
| SRP007169 | MAP4K3 | 8491 | RNAseq | 0.5539 | 0.1275 | |
| SRP008496 | MAP4K3 | 8491 | RNAseq | 0.9877 | 0.0001 | |
| SRP064894 | MAP4K3 | 8491 | RNAseq | 0.0961 | 0.7310 | |
| SRP133303 | MAP4K3 | 8491 | RNAseq | 0.5253 | 0.0028 | |
| SRP159526 | MAP4K3 | 8491 | RNAseq | 0.3786 | 0.0171 | |
| SRP193095 | MAP4K3 | 8491 | RNAseq | 0.0817 | 0.5774 | |
| SRP219564 | MAP4K3 | 8491 | RNAseq | 0.2289 | 0.3541 | |
| TCGA | MAP4K3 | 8491 | RNAseq | -0.2595 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MAP4K3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP4K3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP4K3 | 8491 | 11 | 1 | 18 | |
| GSE20123 | MAP4K3 | 8491 | 9 | 1 | 20 | |
| GSE43470 | MAP4K3 | 8491 | 3 | 0 | 40 | |
| GSE46452 | MAP4K3 | 8491 | 1 | 4 | 54 | |
| GSE47630 | MAP4K3 | 8491 | 7 | 0 | 33 | |
| GSE54993 | MAP4K3 | 8491 | 0 | 5 | 65 | |
| GSE54994 | MAP4K3 | 8491 | 10 | 0 | 43 | |
| GSE60625 | MAP4K3 | 8491 | 0 | 3 | 8 | |
| GSE74703 | MAP4K3 | 8491 | 3 | 0 | 33 | |
| GSE74704 | MAP4K3 | 8491 | 9 | 1 | 10 | |
| TCGA | MAP4K3 | 8491 | 35 | 3 | 58 |
Total number of gains: 88; Total number of losses: 18; Total Number of normals: 382.
Somatic mutations of MAP4K3:
Generating mutation plots.
Highly correlated genes for MAP4K3:
Showing top 20/724 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP4K3 | NOM1 | 0.780999 | 3 | 0 | 3 |
| MAP4K3 | FAM8A1 | 0.765852 | 3 | 0 | 3 |
| MAP4K3 | RAD21 | 0.763422 | 4 | 0 | 4 |
| MAP4K3 | ARHGAP5 | 0.749697 | 3 | 0 | 3 |
| MAP4K3 | RDH14 | 0.74879 | 3 | 0 | 3 |
| MAP4K3 | TMEM218 | 0.746388 | 3 | 0 | 3 |
| MAP4K3 | TRAPPC6B | 0.746367 | 3 | 0 | 3 |
| MAP4K3 | NARS2 | 0.745213 | 3 | 0 | 3 |
| MAP4K3 | ATL1 | 0.732029 | 3 | 0 | 3 |
| MAP4K3 | APPBP2 | 0.731401 | 3 | 0 | 3 |
| MAP4K3 | TSEN2 | 0.723659 | 3 | 0 | 3 |
| MAP4K3 | RNF14 | 0.723337 | 3 | 0 | 3 |
| MAP4K3 | MCPH1 | 0.721091 | 3 | 0 | 3 |
| MAP4K3 | SLFN12 | 0.720922 | 3 | 0 | 3 |
| MAP4K3 | ZNF83 | 0.718498 | 3 | 0 | 3 |
| MAP4K3 | MED7 | 0.717609 | 3 | 0 | 3 |
| MAP4K3 | THOC1 | 0.715181 | 4 | 0 | 3 |
| MAP4K3 | CHL1 | 0.712407 | 3 | 0 | 3 |
| MAP4K3 | SLC19A2 | 0.712245 | 3 | 0 | 3 |
| MAP4K3 | HNRNPH2 | 0.704985 | 3 | 0 | 3 |
For details and further investigation, click here
