| Full name: MOS proto-oncogene, serine/threonine kinase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q12.1 | ||
| Entrez ID: 4342 | HGNC ID: HGNC:7199 | Ensembl Gene: ENSG00000172680 | OMIM ID: 190060 |
| Drug and gene relationship at DGIdb | |||
MOS involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04114 | Oocyte meiosis | |
| hsa04810 | Regulation of actin cytoskeleton | |
| hsa04914 | Progesterone-mediated oocyte maturation |
Expression of MOS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MOS | 4342 | 221367_at | -0.2631 | 0.3888 | |
| GSE20347 | MOS | 4342 | 221367_at | -0.2031 | 0.0010 | |
| GSE23400 | MOS | 4342 | 221367_at | -0.1509 | 0.0000 | |
| GSE26886 | MOS | 4342 | 221367_at | -0.0342 | 0.8125 | |
| GSE29001 | MOS | 4342 | 221367_at | -0.3555 | 0.0201 | |
| GSE38129 | MOS | 4342 | 221367_at | -0.2256 | 0.0000 | |
| GSE45670 | MOS | 4342 | 221367_at | -0.2026 | 0.0467 | |
| GSE53622 | MOS | 4342 | 65789 | -0.2187 | 0.0515 | |
| GSE53624 | MOS | 4342 | 65789 | -0.0305 | 0.7323 | |
| GSE63941 | MOS | 4342 | 221367_at | 0.0493 | 0.7667 | |
| GSE77861 | MOS | 4342 | 221367_at | -0.2871 | 0.0226 | |
| GSE97050 | MOS | 4342 | A_23_P157513 | -0.2680 | 0.2734 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MOS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MOS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MOS | 4342 | 14 | 1 | 15 | |
| GSE20123 | MOS | 4342 | 14 | 1 | 15 | |
| GSE43470 | MOS | 4342 | 13 | 3 | 27 | |
| GSE46452 | MOS | 4342 | 20 | 3 | 36 | |
| GSE47630 | MOS | 4342 | 23 | 1 | 16 | |
| GSE54993 | MOS | 4342 | 1 | 17 | 52 | |
| GSE54994 | MOS | 4342 | 29 | 0 | 24 | |
| GSE60625 | MOS | 4342 | 0 | 4 | 7 | |
| GSE74703 | MOS | 4342 | 12 | 2 | 22 | |
| GSE74704 | MOS | 4342 | 10 | 0 | 10 | |
| TCGA | MOS | 4342 | 43 | 8 | 45 |
Total number of gains: 179; Total number of losses: 40; Total Number of normals: 269.
Somatic mutations of MOS:
Generating mutation plots.
Highly correlated genes for MOS:
Showing top 20/784 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MOS | SHISA8 | 0.868076 | 3 | 0 | 3 |
| MOS | CCDC42 | 0.797869 | 3 | 0 | 3 |
| MOS | CALML6 | 0.776387 | 3 | 0 | 3 |
| MOS | PGC | 0.773317 | 3 | 0 | 3 |
| MOS | STAC3 | 0.770188 | 3 | 0 | 3 |
| MOS | GPR78 | 0.769981 | 3 | 0 | 3 |
| MOS | C10orf90 | 0.763175 | 3 | 0 | 3 |
| MOS | KIRREL2 | 0.76203 | 3 | 0 | 3 |
| MOS | ASIC2 | 0.760944 | 4 | 0 | 4 |
| MOS | KRT74 | 0.757394 | 3 | 0 | 3 |
| MOS | CDH10 | 0.751358 | 3 | 0 | 3 |
| MOS | ABCC6 | 0.74559 | 3 | 0 | 3 |
| MOS | KIF17 | 0.742692 | 3 | 0 | 3 |
| MOS | SPINT3 | 0.727157 | 5 | 0 | 5 |
| MOS | FMR1NB | 0.723286 | 3 | 0 | 3 |
| MOS | SVOPL | 0.712162 | 3 | 0 | 3 |
| MOS | ZGLP1 | 0.71211 | 4 | 0 | 4 |
| MOS | GUCY2C | 0.70349 | 4 | 0 | 3 |
| MOS | DCAF12L2 | 0.691738 | 3 | 0 | 3 |
| MOS | SLC6A18 | 0.689042 | 5 | 0 | 4 |
For details and further investigation, click here
