| Full name: acid sensing ion channel subunit 2 | Alias Symbol: ASIC2a|BNC1|BNaC1|hBNaC1|MDEG | ||
| Type: protein-coding gene | Cytoband: 17q11.2-q12 | ||
| Entrez ID: 40 | HGNC ID: HGNC:99 | Ensembl Gene: ENSG00000108684 | OMIM ID: 601784 |
| Drug and gene relationship at DGIdb | |||
ASIC2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of ASIC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASIC2 | 40 | 206690_at | -0.0518 | 0.8440 | |
| GSE20347 | ASIC2 | 40 | 206690_at | -0.0752 | 0.3657 | |
| GSE23400 | ASIC2 | 40 | 206690_at | -0.1538 | 0.0000 | |
| GSE26886 | ASIC2 | 40 | 206690_at | 0.0284 | 0.7591 | |
| GSE29001 | ASIC2 | 40 | 206690_at | -0.2105 | 0.0853 | |
| GSE38129 | ASIC2 | 40 | 206690_at | -0.1698 | 0.0188 | |
| GSE45670 | ASIC2 | 40 | 206690_at | -0.0166 | 0.8866 | |
| GSE53622 | ASIC2 | 40 | 58121 | 0.2422 | 0.0392 | |
| GSE53624 | ASIC2 | 40 | 58121 | 0.0916 | 0.3593 | |
| GSE63941 | ASIC2 | 40 | 206690_at | -0.0793 | 0.7177 | |
| GSE77861 | ASIC2 | 40 | 206690_at | -0.1612 | 0.1298 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ASIC2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of ASIC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASIC2 | 40 | 7 | 1 | 22 | |
| GSE20123 | ASIC2 | 40 | 7 | 1 | 22 | |
| GSE43470 | ASIC2 | 40 | 1 | 3 | 39 | |
| GSE46452 | ASIC2 | 40 | 34 | 0 | 25 | |
| GSE47630 | ASIC2 | 40 | 7 | 1 | 32 | |
| GSE54993 | ASIC2 | 40 | 3 | 3 | 64 | |
| GSE54994 | ASIC2 | 40 | 8 | 9 | 36 | |
| GSE60625 | ASIC2 | 40 | 4 | 0 | 7 | |
| GSE74703 | ASIC2 | 40 | 1 | 2 | 33 | |
| GSE74704 | ASIC2 | 40 | 4 | 1 | 15 | |
| TCGA | ASIC2 | 40 | 20 | 9 | 67 |
Total number of gains: 96; Total number of losses: 30; Total Number of normals: 362.
Somatic mutations of ASIC2:
Generating mutation plots.
Highly correlated genes for ASIC2:
Showing top 20/679 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASIC2 | MOS | 0.760944 | 4 | 0 | 4 |
| ASIC2 | CAMK1G | 0.709966 | 4 | 0 | 4 |
| ASIC2 | CNR2 | 0.6867 | 5 | 0 | 4 |
| ASIC2 | FEV | 0.684387 | 5 | 0 | 5 |
| ASIC2 | CKM | 0.684166 | 3 | 0 | 3 |
| ASIC2 | TMEM198 | 0.682062 | 3 | 0 | 3 |
| ASIC2 | FGF23 | 0.681207 | 6 | 0 | 6 |
| ASIC2 | ATRNL1 | 0.680032 | 4 | 0 | 4 |
| ASIC2 | ATAT1 | 0.67772 | 3 | 0 | 3 |
| ASIC2 | BTNL3 | 0.676778 | 6 | 0 | 6 |
| ASIC2 | SLC13A3 | 0.675726 | 4 | 0 | 4 |
| ASIC2 | PLIN1 | 0.669657 | 4 | 0 | 3 |
| ASIC2 | CETP | 0.669088 | 3 | 0 | 3 |
| ASIC2 | LY9 | 0.667486 | 5 | 0 | 5 |
| ASIC2 | PHLDB1 | 0.661556 | 5 | 0 | 5 |
| ASIC2 | CST5 | 0.65988 | 3 | 0 | 3 |
| ASIC2 | RARG | 0.653284 | 4 | 0 | 4 |
| ASIC2 | TEX11 | 0.653146 | 4 | 0 | 4 |
| ASIC2 | FKBP8 | 0.653139 | 4 | 0 | 3 |
| ASIC2 | RALYL | 0.651612 | 4 | 0 | 3 |
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