| Full name: membrane spanning 4-domains A2 | Alias Symbol: MS4A1 | ||
| Type: protein-coding gene | Cytoband: 11q12.1 | ||
| Entrez ID: 2206 | HGNC ID: HGNC:7316 | Ensembl Gene: ENSG00000149534 | OMIM ID: 147138 |
| Drug and gene relationship at DGIdb | |||
MS4A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04071 | Sphingolipid signaling pathway | |
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04664 | Fc epsilon RI signaling pathway |
Expression of MS4A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MS4A2 | 2206 | 207497_s_at | -0.2982 | 0.4057 | |
| GSE20347 | MS4A2 | 2206 | 207497_s_at | 0.0518 | 0.5314 | |
| GSE23400 | MS4A2 | 2206 | 207496_at | -0.1242 | 0.0000 | |
| GSE26886 | MS4A2 | 2206 | 207497_s_at | -0.0805 | 0.3671 | |
| GSE29001 | MS4A2 | 2206 | 207497_s_at | -0.0308 | 0.8058 | |
| GSE38129 | MS4A2 | 2206 | 207496_at | -0.4618 | 0.0191 | |
| GSE45670 | MS4A2 | 2206 | 207496_at | -1.1413 | 0.0076 | |
| GSE53622 | MS4A2 | 2206 | 89285 | -1.2040 | 0.0000 | |
| GSE53624 | MS4A2 | 2206 | 89285 | -1.0174 | 0.0000 | |
| GSE63941 | MS4A2 | 2206 | 207497_s_at | 0.0911 | 0.4511 | |
| GSE77861 | MS4A2 | 2206 | 207497_s_at | 0.0188 | 0.8535 | |
| GSE97050 | MS4A2 | 2206 | A_33_P3295313 | -0.0801 | 0.7388 | |
| SRP007169 | MS4A2 | 2206 | RNAseq | -0.5808 | 0.3834 | |
| SRP064894 | MS4A2 | 2206 | RNAseq | -0.8548 | 0.0631 | |
| SRP133303 | MS4A2 | 2206 | RNAseq | -1.4548 | 0.0001 | |
| SRP159526 | MS4A2 | 2206 | RNAseq | 0.0252 | 0.9789 | |
| SRP193095 | MS4A2 | 2206 | RNAseq | -0.4458 | 0.0901 | |
| SRP219564 | MS4A2 | 2206 | RNAseq | 0.4810 | 0.4913 | |
| TCGA | MS4A2 | 2206 | RNAseq | -1.3746 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by MS4A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MS4A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MS4A2 | 2206 | 1 | 5 | 24 | |
| GSE20123 | MS4A2 | 2206 | 1 | 5 | 24 | |
| GSE43470 | MS4A2 | 2206 | 2 | 5 | 36 | |
| GSE46452 | MS4A2 | 2206 | 8 | 4 | 47 | |
| GSE47630 | MS4A2 | 2206 | 3 | 8 | 29 | |
| GSE54993 | MS4A2 | 2206 | 3 | 0 | 67 | |
| GSE54994 | MS4A2 | 2206 | 6 | 5 | 42 | |
| GSE60625 | MS4A2 | 2206 | 0 | 3 | 8 | |
| GSE74703 | MS4A2 | 2206 | 2 | 3 | 31 | |
| GSE74704 | MS4A2 | 2206 | 1 | 4 | 15 | |
| TCGA | MS4A2 | 2206 | 15 | 10 | 71 |
Total number of gains: 42; Total number of losses: 52; Total Number of normals: 394.
Somatic mutations of MS4A2:
Generating mutation plots.
Highly correlated genes for MS4A2:
Showing top 20/313 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MS4A2 | HPGDS | 0.683232 | 9 | 0 | 6 |
| MS4A2 | PLCXD3 | 0.675599 | 4 | 0 | 4 |
| MS4A2 | C1QTNF7 | 0.672406 | 4 | 0 | 4 |
| MS4A2 | CCPG1 | 0.671532 | 4 | 0 | 3 |
| MS4A2 | KIT | 0.668493 | 6 | 0 | 5 |
| MS4A2 | SLC18A2 | 0.667559 | 8 | 0 | 5 |
| MS4A2 | ZNF366 | 0.665116 | 3 | 0 | 3 |
| MS4A2 | AZGP1 | 0.664461 | 3 | 0 | 3 |
| MS4A2 | S100G | 0.660455 | 3 | 0 | 3 |
| MS4A2 | ITGA8 | 0.657332 | 6 | 0 | 5 |
| MS4A2 | FGF10 | 0.657121 | 4 | 0 | 3 |
| MS4A2 | CCL14 | 0.65621 | 3 | 0 | 3 |
| MS4A2 | ORM1 | 0.655629 | 3 | 0 | 3 |
| MS4A2 | KIAA1324 | 0.654744 | 4 | 0 | 4 |
| MS4A2 | GPR34 | 0.653174 | 3 | 0 | 3 |
| MS4A2 | LINC01082 | 0.651605 | 4 | 0 | 4 |
| MS4A2 | LAMA2 | 0.649713 | 5 | 0 | 5 |
| MS4A2 | CHST4 | 0.645554 | 5 | 0 | 3 |
| MS4A2 | CFD | 0.642584 | 6 | 0 | 6 |
| MS4A2 | KL | 0.640737 | 5 | 0 | 4 |
For details and further investigation, click here
