| Full name: integrin subunit alpha 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10p13 | ||
| Entrez ID: 8516 | HGNC ID: HGNC:6144 | Ensembl Gene: ENSG00000077943 | OMIM ID: 604063 |
| Drug and gene relationship at DGIdb | |||
ITGA8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ITGA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGA8 | 8516 | 235666_at | -2.0692 | 0.0171 | |
| GSE20347 | ITGA8 | 8516 | 214265_at | -0.9678 | 0.0005 | |
| GSE23400 | ITGA8 | 8516 | 214265_at | -0.7208 | 0.0000 | |
| GSE26886 | ITGA8 | 8516 | 242071_x_at | 0.5789 | 0.0003 | |
| GSE29001 | ITGA8 | 8516 | 214265_at | -1.0525 | 0.0001 | |
| GSE38129 | ITGA8 | 8516 | 214265_at | -1.8735 | 0.0000 | |
| GSE45670 | ITGA8 | 8516 | 235666_at | -2.7255 | 0.0000 | |
| GSE53622 | ITGA8 | 8516 | 90742 | -2.1069 | 0.0000 | |
| GSE53624 | ITGA8 | 8516 | 90742 | -2.2809 | 0.0000 | |
| GSE63941 | ITGA8 | 8516 | 242071_x_at | 0.3187 | 0.0388 | |
| GSE77861 | ITGA8 | 8516 | 242071_x_at | 0.0055 | 0.9869 | |
| GSE97050 | ITGA8 | 8516 | A_23_P46781 | -1.9646 | 0.1204 | |
| SRP007169 | ITGA8 | 8516 | RNAseq | -0.0648 | 0.9009 | |
| SRP064894 | ITGA8 | 8516 | RNAseq | -1.2153 | 0.0015 | |
| SRP133303 | ITGA8 | 8516 | RNAseq | -1.9077 | 0.0000 | |
| SRP159526 | ITGA8 | 8516 | RNAseq | -0.8871 | 0.1095 | |
| SRP193095 | ITGA8 | 8516 | RNAseq | 0.1910 | 0.6267 | |
| TCGA | ITGA8 | 8516 | RNAseq | -1.8422 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by ITGA8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGA8 | 8516 | 3 | 8 | 19 | |
| GSE20123 | ITGA8 | 8516 | 3 | 7 | 20 | |
| GSE43470 | ITGA8 | 8516 | 3 | 5 | 35 | |
| GSE46452 | ITGA8 | 8516 | 1 | 14 | 44 | |
| GSE47630 | ITGA8 | 8516 | 5 | 15 | 20 | |
| GSE54993 | ITGA8 | 8516 | 10 | 0 | 60 | |
| GSE54994 | ITGA8 | 8516 | 4 | 9 | 40 | |
| GSE60625 | ITGA8 | 8516 | 0 | 0 | 11 | |
| GSE74703 | ITGA8 | 8516 | 2 | 3 | 31 | |
| GSE74704 | ITGA8 | 8516 | 0 | 6 | 14 | |
| TCGA | ITGA8 | 8516 | 20 | 25 | 51 |
Total number of gains: 51; Total number of losses: 92; Total Number of normals: 345.
Somatic mutations of ITGA8:
Generating mutation plots.
Highly correlated genes for ITGA8:
Showing top 20/663 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGA8 | CLEC3B | 0.873528 | 3 | 0 | 3 |
| ITGA8 | CYP21A2 | 0.810439 | 3 | 0 | 3 |
| ITGA8 | XKR4 | 0.787363 | 5 | 0 | 5 |
| ITGA8 | PLCXD3 | 0.785704 | 4 | 0 | 4 |
| ITGA8 | FXYD1 | 0.777315 | 8 | 0 | 8 |
| ITGA8 | ITIH5 | 0.77639 | 9 | 0 | 9 |
| ITGA8 | MEOX2 | 0.767861 | 8 | 0 | 8 |
| ITGA8 | TNFSF12 | 0.766551 | 3 | 0 | 3 |
| ITGA8 | IGSF10 | 0.764591 | 5 | 0 | 5 |
| ITGA8 | TCEAL5 | 0.764587 | 3 | 0 | 3 |
| ITGA8 | GPRASP2 | 0.759222 | 3 | 0 | 3 |
| ITGA8 | PLAC9 | 0.756699 | 6 | 0 | 6 |
| ITGA8 | CHADL | 0.756064 | 3 | 0 | 3 |
| ITGA8 | LIFR | 0.751493 | 6 | 0 | 5 |
| ITGA8 | RERG | 0.746705 | 5 | 0 | 5 |
| ITGA8 | NCKIPSD | 0.740181 | 3 | 0 | 3 |
| ITGA8 | TGFBR3 | 0.739659 | 9 | 0 | 8 |
| ITGA8 | PDZRN4 | 0.739167 | 9 | 0 | 9 |
| ITGA8 | SLC43A2 | 0.738194 | 3 | 0 | 3 |
| ITGA8 | BCHE | 0.736781 | 8 | 0 | 8 |
For details and further investigation, click here
