| Full name: klotho | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 13q13.1 | ||
| Entrez ID: 9365 | HGNC ID: HGNC:6344 | Ensembl Gene: ENSG00000133116 | OMIM ID: 604824 |
| Drug and gene relationship at DGIdb | |||
KL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04211 | Longevity regulating pathway - mammal | |
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
Expression of KL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KL | 9365 | 205978_at | -0.6334 | 0.4048 | |
| GSE20347 | KL | 9365 | 205978_at | -0.1341 | 0.0520 | |
| GSE23400 | KL | 9365 | 205978_at | -0.0465 | 0.0768 | |
| GSE26886 | KL | 9365 | 205978_at | 0.2359 | 0.2552 | |
| GSE29001 | KL | 9365 | 205978_at | -0.0768 | 0.8193 | |
| GSE38129 | KL | 9365 | 205978_at | -0.5462 | 0.0082 | |
| GSE45670 | KL | 9365 | 205978_at | -0.7506 | 0.0049 | |
| GSE53622 | KL | 9365 | 34635 | -1.2745 | 0.0000 | |
| GSE53624 | KL | 9365 | 34635 | -1.4242 | 0.0000 | |
| GSE63941 | KL | 9365 | 205978_at | 0.4944 | 0.7671 | |
| GSE77861 | KL | 9365 | 205978_at | -0.0986 | 0.1539 | |
| SRP133303 | KL | 9365 | RNAseq | -1.0353 | 0.0064 | |
| SRP159526 | KL | 9365 | RNAseq | -0.3074 | 0.5802 | |
| TCGA | KL | 9365 | RNAseq | -1.8961 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by KL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KL | 9365 | 0 | 15 | 15 | |
| GSE20123 | KL | 9365 | 0 | 14 | 16 | |
| GSE43470 | KL | 9365 | 2 | 13 | 28 | |
| GSE46452 | KL | 9365 | 0 | 33 | 26 | |
| GSE47630 | KL | 9365 | 2 | 27 | 11 | |
| GSE54993 | KL | 9365 | 12 | 2 | 56 | |
| GSE54994 | KL | 9365 | 2 | 15 | 36 | |
| GSE60625 | KL | 9365 | 0 | 3 | 8 | |
| GSE74703 | KL | 9365 | 2 | 10 | 24 | |
| GSE74704 | KL | 9365 | 0 | 12 | 8 | |
| TCGA | KL | 9365 | 8 | 37 | 51 |
Total number of gains: 28; Total number of losses: 181; Total Number of normals: 279.
Somatic mutations of KL:
Generating mutation plots.
Highly correlated genes for KL:
Showing top 20/806 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KL | C1QTNF7 | 0.799071 | 4 | 0 | 4 |
| KL | KLHL41 | 0.775323 | 3 | 0 | 3 |
| KL | PREX2 | 0.775284 | 3 | 0 | 3 |
| KL | SHE | 0.773944 | 3 | 0 | 3 |
| KL | ZCWPW2 | 0.766176 | 3 | 0 | 3 |
| KL | C1QTNF2 | 0.758102 | 4 | 0 | 4 |
| KL | ALDH1A2 | 0.751092 | 3 | 0 | 3 |
| KL | ADAMTSL1 | 0.736827 | 4 | 0 | 4 |
| KL | XKR4 | 0.734793 | 4 | 0 | 4 |
| KL | SLC8A1 | 0.733515 | 3 | 0 | 3 |
| KL | ANO5 | 0.732116 | 4 | 0 | 4 |
| KL | MKX | 0.730311 | 3 | 0 | 3 |
| KL | PLN | 0.725435 | 6 | 0 | 6 |
| KL | LRRN4CL | 0.725377 | 4 | 0 | 4 |
| KL | ARHGAP6 | 0.724582 | 7 | 0 | 6 |
| KL | GIMAP8 | 0.723261 | 3 | 0 | 3 |
| KL | RGS9 | 0.722473 | 3 | 0 | 3 |
| KL | TMEM100 | 0.719643 | 8 | 0 | 7 |
| KL | SHISA3 | 0.718965 | 5 | 0 | 4 |
| KL | CYP2U1 | 0.718841 | 5 | 0 | 5 |
For details and further investigation, click here
