| Full name: hematopoietic prostaglandin D synthase | Alias Symbol: GSTS|PGDS|H-PGDS|PGD2|GSTS1-1|GSTS1 | ||
| Type: protein-coding gene | Cytoband: 4q22.3 | ||
| Entrez ID: 27306 | HGNC ID: HGNC:17890 | Ensembl Gene: ENSG00000163106 | OMIM ID: 602598 |
| Drug and gene relationship at DGIdb | |||
Expression of HPGDS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPGDS | 27306 | 206726_at | -0.7507 | 0.3103 | |
| GSE20347 | HPGDS | 27306 | 206726_at | -0.1648 | 0.1192 | |
| GSE23400 | HPGDS | 27306 | 206726_at | -0.1528 | 0.0000 | |
| GSE26886 | HPGDS | 27306 | 206726_at | -0.6242 | 0.0158 | |
| GSE29001 | HPGDS | 27306 | 206726_at | -0.3382 | 0.0893 | |
| GSE38129 | HPGDS | 27306 | 206726_at | -0.3832 | 0.0508 | |
| GSE45670 | HPGDS | 27306 | 206726_at | -1.0970 | 0.0003 | |
| GSE53622 | HPGDS | 27306 | 67753 | -1.2151 | 0.0000 | |
| GSE53624 | HPGDS | 27306 | 67753 | -1.0270 | 0.0000 | |
| GSE63941 | HPGDS | 27306 | 206726_at | 0.0157 | 0.9438 | |
| GSE77861 | HPGDS | 27306 | 206726_at | -0.1004 | 0.6282 | |
| GSE97050 | HPGDS | 27306 | A_23_P10506 | -0.5111 | 0.2764 | |
| SRP064894 | HPGDS | 27306 | RNAseq | -0.6980 | 0.0435 | |
| SRP133303 | HPGDS | 27306 | RNAseq | -1.0313 | 0.0066 | |
| SRP159526 | HPGDS | 27306 | RNAseq | -0.0652 | 0.8927 | |
| SRP219564 | HPGDS | 27306 | RNAseq | -0.2811 | 0.6260 | |
| TCGA | HPGDS | 27306 | RNAseq | -1.0156 | 0.0020 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by HPGDS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPGDS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPGDS | 27306 | 0 | 12 | 18 | |
| GSE20123 | HPGDS | 27306 | 0 | 12 | 18 | |
| GSE43470 | HPGDS | 27306 | 0 | 16 | 27 | |
| GSE46452 | HPGDS | 27306 | 1 | 36 | 22 | |
| GSE47630 | HPGDS | 27306 | 0 | 20 | 20 | |
| GSE54993 | HPGDS | 27306 | 8 | 0 | 62 | |
| GSE54994 | HPGDS | 27306 | 1 | 11 | 41 | |
| GSE60625 | HPGDS | 27306 | 0 | 3 | 8 | |
| GSE74703 | HPGDS | 27306 | 0 | 14 | 22 | |
| GSE74704 | HPGDS | 27306 | 0 | 6 | 14 | |
| TCGA | HPGDS | 27306 | 8 | 40 | 48 |
Total number of gains: 18; Total number of losses: 170; Total Number of normals: 300.
Somatic mutations of HPGDS:
Generating mutation plots.
Highly correlated genes for HPGDS:
Showing top 20/651 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPGDS | CCL23 | 0.747557 | 3 | 0 | 3 |
| HPGDS | PID1 | 0.723873 | 7 | 0 | 7 |
| HPGDS | CCL14 | 0.713555 | 3 | 0 | 3 |
| HPGDS | CCPG1 | 0.712863 | 3 | 0 | 3 |
| HPGDS | P2RY12 | 0.706897 | 6 | 0 | 6 |
| HPGDS | RNASE1 | 0.698847 | 6 | 0 | 6 |
| HPGDS | CYP21A2 | 0.696719 | 3 | 0 | 3 |
| HPGDS | LRRN4CL | 0.696042 | 5 | 0 | 5 |
| HPGDS | CNRIP1 | 0.694408 | 5 | 0 | 5 |
| HPGDS | CLEC3B | 0.693409 | 3 | 0 | 3 |
| HPGDS | IGSF10 | 0.692376 | 5 | 0 | 5 |
| HPGDS | FIBIN | 0.686519 | 3 | 0 | 3 |
| HPGDS | PPM1M | 0.683932 | 4 | 0 | 4 |
| HPGDS | MS4A2 | 0.683232 | 9 | 0 | 6 |
| HPGDS | NR2F1 | 0.682384 | 3 | 0 | 3 |
| HPGDS | LYVE1 | 0.678441 | 9 | 0 | 9 |
| HPGDS | TFPI | 0.678199 | 6 | 0 | 6 |
| HPGDS | PLCXD3 | 0.672675 | 5 | 0 | 5 |
| HPGDS | ARHGAP31 | 0.670247 | 5 | 0 | 5 |
| HPGDS | ZNF423 | 0.668834 | 5 | 0 | 5 |
For details and further investigation, click here
