Full name: KIT proto-oncogene, receptor tyrosine kinase	Alias Symbol: CD117|SCFR|C-Kit
Type: protein-coding gene	Cytoband: 4q12
Entrez ID: 3815	HGNC ID: HGNC:6342	Ensembl Gene: ENSG00000157404	OMIM ID: 164920
Drug and gene relationship at DGIdb
Screen Evidence: This gene has been idenfitied as a common driver in this paper. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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KIT involved pathways:

KEGG pathway	Description	View
hsa04014	Ras signaling pathway	View
hsa04015	Rap1 signaling pathway	View
hsa04072	Phospholipase D signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04916	Melanogenesis	View
hsa05200	Pathways in cancer	View
hsa05221	Acute myeloid leukemia	View

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Expression of KIT:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	KIT	3815	205051_s_at	-1.5584	0.3262	Show
GSE20347	KIT	3815	205051_s_at	-0.7245	0.0264	Show
GSE23400	KIT	3815	205051_s_at	-0.7083	0.0000	Show
GSE26886	KIT	3815	205051_s_at	0.2583	0.7007	Show
GSE29001	KIT	3815	205051_s_at	-0.7785	0.2136	Show
GSE38129	KIT	3815	205051_s_at	-0.9461	0.0033	Show
GSE45670	KIT	3815	205051_s_at	-2.0124	0.0000	Show
GSE53622	KIT	3815	129158	-1.6327	0.0000	Show
GSE53624	KIT	3815	117840	-1.5127	0.0000	Show
GSE63941	KIT	3815	205051_s_at	-4.7009	0.0004	Show
GSE77861	KIT	3815	205051_s_at	-0.2614	0.1941	Show
GSE97050	KIT	3815	A_33_P3303245	-1.5780	0.0640	Show
SRP007169	KIT	3815	RNAseq	-1.6929	0.0023	Show
SRP008496	KIT	3815	RNAseq	-0.9455	0.0129	Show
SRP064894	KIT	3815	RNAseq	-0.9652	0.0187	Show
SRP133303	KIT	3815	RNAseq	-1.6871	0.0000	Show
SRP159526	KIT	3815	RNAseq	0.1487	0.7427	Show
SRP193095	KIT	3815	RNAseq	-0.8521	0.0009	Show
SRP219564	KIT	3815	RNAseq	0.2026	0.8317	Show
TCGA	KIT	3815	RNAseq	-1.1483	0.0000	Show

Upregulated datasets: 0; Downregulated datasets: 7.  Download Data

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Survival by KIT expression:

 

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Copy number change of KIT:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	KIT	3815	3	11	16	Show
GSE20123	KIT	3815	2	11	17	Show
GSE43470	KIT	3815	0	14	29	Show
GSE46452	KIT	3815	1	36	22	Show
GSE47630	KIT	3815	1	18	21	Show
GSE54993	KIT	3815	7	0	63	Show
GSE54994	KIT	3815	2	10	41	Show
GSE60625	KIT	3815	0	0	11	Show
GSE74703	KIT	3815	0	12	24	Show
GSE74704	KIT	3815	1	6	13	Show
TCGA	KIT	3815	19	27	50	Show

Total number of gains: 36; Total number of losses: 145; Total Number of normals: 307.  Download Data

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Somatic mutations of KIT:

 

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Highly correlated genes for KIT:

 

Showing top 20/1110 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
KIT	AFF3	0.811781	3	0	3
KIT	FAM13C	0.807904	4	0	4
KIT	PRKAR2B	0.769843	11	0	11
KIT	PREX2	0.768949	4	0	4
KIT	SORCS1	0.767433	4	0	4
KIT	MYOCD	0.763926	5	0	5
KIT	CLEC3B	0.756363	3	0	3
KIT	MRVI1	0.755711	6	0	6
KIT	XKR4	0.755022	5	0	5
KIT	CYP4V2	0.752919	4	0	4
KIT	CBX7	0.750935	9	0	9
KIT	PARD3B	0.747696	5	0	5
KIT	JAM2	0.745737	11	0	9
KIT	ABCA8	0.744468	10	0	9
KIT	CYP21A2	0.741498	3	0	3
KIT	MEOX2	0.741465	8	0	8
KIT	ARHGAP6	0.741025	10	0	10
KIT	PPP1R12B	0.732926	11	0	10
KIT	PLAC9	0.731858	5	0	4
KIT	HEIH	0.731825	3	0	3

For details and further investigation, click here