KIT

 

Full name: KIT proto-oncogene, receptor tyrosine kinase Alias Symbol: CD117|SCFR|C-Kit
Type: protein-coding gene Cytoband: 4q12
Entrez ID: 3815 HGNC ID: HGNC:6342 Ensembl Gene: ENSG00000157404 OMIM ID: 164920
Related drugs: AKN-028, AMUVATINIB, AST-487, AXITINIB, Anlotinib, BEVACIZUMAB, CABOZANTINIB, CEDIRANIB, CHEMBL1908396, CHEMBL2325503... [more]
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

KIT involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05221Acute myeloid leukemia

 

Expression of KIT:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KIT 3815 205051_s_at -1.5584 0.3262
GSE20347 KIT 3815 205051_s_at -0.7245 0.0264
GSE23400 KIT 3815 205051_s_at -0.7083 0.0000
GSE26886 KIT 3815 205051_s_at 0.2583 0.7007
GSE29001 KIT 3815 205051_s_at -0.7785 0.2136
GSE38129 KIT 3815 205051_s_at -0.9461 0.0033
GSE45670 KIT 3815 205051_s_at -2.0124 0.0000
GSE53622 KIT 3815 129158 -1.6327 0.0000
GSE53624 KIT 3815 117840 -1.5127 0.0000
GSE63941 KIT 3815 205051_s_at -4.7009 0.0004
GSE77861 KIT 3815 205051_s_at -0.2614 0.1941
GSE97050 KIT 3815 A_33_P3303245 -1.5780 0.0640
SRP007169 KIT 3815 RNAseq -1.6929 0.0023
SRP008496 KIT 3815 RNAseq -0.9455 0.0129
SRP064894 KIT 3815 RNAseq -0.9652 0.0187
SRP133303 KIT 3815 RNAseq -1.6871 0.0000
SRP159526 KIT 3815 RNAseq 0.1487 0.7427
SRP193095 KIT 3815 RNAseq -0.8521 0.0009
SRP219564 KIT 3815 RNAseq 0.2026 0.8317
TCGA KIT 3815 RNAseq -1.1483 0.0000

Upregulated datasets: 0; Downregulated datasets: 7.  

 

Survival by KIT expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KIT:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KIT 3815 3 11 16
GSE20123 KIT 3815 2 11 17
GSE43470 KIT 3815 0 14 29
GSE46452 KIT 3815 1 36 22
GSE47630 KIT 3815 1 18 21
GSE54993 KIT 3815 7 0 63
GSE54994 KIT 3815 2 10 41
GSE60625 KIT 3815 0 0 11
GSE74703 KIT 3815 0 12 24
GSE74704 KIT 3815 1 6 13
TCGA KIT 3815 19 27 50

Total number of gains: 36; Total number of losses: 145; Total Number of normals: 307.  

 

Somatic mutations of KIT:

 

Generating mutation plots.

 

Highly correlated genes for KIT:

 

Showing top 20/1110 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KITAFF30.811781303
KITFAM13C0.807904404
KITPRKAR2B0.76984311011
KITPREX20.768949404
KITSORCS10.767433404
KITMYOCD0.763926505
KITCLEC3B0.756363303
KITMRVI10.755711606
KITXKR40.755022505
KITCYP4V20.752919404
KITCBX70.750935909
KITPARD3B0.747696505
KITJAM20.7457371109
KITABCA80.7444681009
KITCYP21A20.741498303
KITMEOX20.741465808
KITARHGAP60.74102510010
KITPPP1R12B0.73292611010
KITPLAC90.731858504
KITHEIH0.731825303

For details and further investigation, click here