MTOR

 

Full name: mechanistic target of rapamycin kinase Alias Symbol: RAFT1|RAPT1|FLJ44809
Type: protein-coding gene Cytoband: 1p36.22
Entrez ID: 2475 HGNC ID: HGNC:3942 Ensembl Gene: ENSG00000198793 OMIM ID: 601231
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 259/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

MTOR involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04066HIF-1 signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04630Jak-STAT signaling pathway
hsa04910Insulin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04930Type II diabetes mellitus
hsa04931Insulin resistance
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05221Acute myeloid leukemia
hsa05231Choline metabolism in cancer

 

Expression of MTOR:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MTOR 2475 202288_at 0.3848 0.2698
GSE20347 MTOR 2475 202288_at 0.0030 0.9795
GSE23400 MTOR 2475 215381_at -0.1013 0.0220
GSE26886 MTOR 2475 202288_at 0.1685 0.3292
GSE29001 MTOR 2475 202288_at 0.0882 0.7288
GSE38129 MTOR 2475 202288_at 0.0519 0.6123
GSE45670 MTOR 2475 202288_at 0.2171 0.1105
GSE53622 MTOR 2475 54878 0.3090 0.0000
GSE53624 MTOR 2475 54878 0.2681 0.0000
GSE63941 MTOR 2475 202288_at -0.5148 0.1877
GSE77861 MTOR 2475 202288_at -0.1462 0.0792
GSE97050 MTOR 2475 A_23_P34606 0.3219 0.3185
SRP007169 MTOR 2475 RNAseq 0.7769 0.1552
SRP008496 MTOR 2475 RNAseq 0.7037 0.0384
SRP064894 MTOR 2475 RNAseq 0.2586 0.1999
SRP133303 MTOR 2475 RNAseq 0.2228 0.1352
SRP159526 MTOR 2475 RNAseq 0.1398 0.6032
SRP193095 MTOR 2475 RNAseq 0.3221 0.0001
SRP219564 MTOR 2475 RNAseq 0.0146 0.9505
TCGA MTOR 2475 RNAseq -0.0440 0.3258

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MTOR expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MTOR:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MTOR 2475 0 5 25
GSE20123 MTOR 2475 0 4 26
GSE43470 MTOR 2475 6 5 32
GSE46452 MTOR 2475 7 1 51
GSE47630 MTOR 2475 8 4 28
GSE54993 MTOR 2475 3 1 66
GSE54994 MTOR 2475 11 4 38
GSE60625 MTOR 2475 0 0 11
GSE74703 MTOR 2475 5 3 28
GSE74704 MTOR 2475 0 0 20
TCGA MTOR 2475 9 23 64

Total number of gains: 49; Total number of losses: 50; Total Number of normals: 389.  

 

Somatic mutations of MTOR:

 

Generating mutation plots.

 

Highly correlated genes for MTOR:

 

Showing top 20/366 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MTORZSCAN120.796669303
MTORROMO10.783514303
MTORZBTB440.775003303
MTORNUP540.774994303
MTORFNTA0.772524303
MTORMOB3C0.75627303
MTORZNF3940.743607303
MTORACBD50.737381303
MTORGPHN0.73565303
MTORNCOA60.734841403
MTORBAG60.7341403
MTORMAGED10.730307303
MTORGOLGA70.726942303
MTORTSEN150.726059303
MTORSWT10.725814303
MTORCDC730.723354303
MTORDCAF100.715048303
MTORUSP160.709179303
MTORKBTBD70.705493303
MTORST8SIA6-AS10.702559303

For details and further investigation, click here