| Full name: gephyrin | Alias Symbol: KIAA1385 | ||
| Type: protein-coding gene | Cytoband: 14q23.3 | ||
| Entrez ID: 10243 | HGNC ID: HGNC:15465 | Ensembl Gene: ENSG00000171723 | OMIM ID: 603930 |
| Drug and gene relationship at DGIdb | |||
GPHN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse |
Expression of GPHN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPHN | 10243 | 223319_at | -0.6148 | 0.5353 | |
| GSE20347 | GPHN | 10243 | 220773_s_at | 0.2298 | 0.1093 | |
| GSE23400 | GPHN | 10243 | 220773_s_at | 0.2092 | 0.0021 | |
| GSE26886 | GPHN | 10243 | 223319_at | 0.2127 | 0.4302 | |
| GSE29001 | GPHN | 10243 | 220773_s_at | 0.1882 | 0.5108 | |
| GSE38129 | GPHN | 10243 | 220773_s_at | 0.2983 | 0.0067 | |
| GSE45670 | GPHN | 10243 | 223319_at | -0.1284 | 0.4412 | |
| GSE53622 | GPHN | 10243 | 70682 | -0.3751 | 0.0015 | |
| GSE53624 | GPHN | 10243 | 70682 | -0.3630 | 0.0001 | |
| GSE63941 | GPHN | 10243 | 223319_at | 0.2403 | 0.7179 | |
| GSE77861 | GPHN | 10243 | 223319_at | -0.0804 | 0.8255 | |
| GSE97050 | GPHN | 10243 | A_33_P3414422 | 0.1423 | 0.7247 | |
| SRP007169 | GPHN | 10243 | RNAseq | -0.2480 | 0.7517 | |
| SRP008496 | GPHN | 10243 | RNAseq | -0.3392 | 0.4159 | |
| SRP064894 | GPHN | 10243 | RNAseq | -0.1352 | 0.3635 | |
| SRP133303 | GPHN | 10243 | RNAseq | 0.0376 | 0.8806 | |
| SRP159526 | GPHN | 10243 | RNAseq | -0.2687 | 0.4491 | |
| SRP193095 | GPHN | 10243 | RNAseq | 0.0639 | 0.6374 | |
| SRP219564 | GPHN | 10243 | RNAseq | -0.0571 | 0.7750 | |
| TCGA | GPHN | 10243 | RNAseq | -0.2047 | 0.0254 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GPHN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPHN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPHN | 10243 | 7 | 3 | 20 | |
| GSE20123 | GPHN | 10243 | 7 | 3 | 20 | |
| GSE43470 | GPHN | 10243 | 8 | 2 | 33 | |
| GSE46452 | GPHN | 10243 | 16 | 3 | 40 | |
| GSE47630 | GPHN | 10243 | 11 | 9 | 20 | |
| GSE54993 | GPHN | 10243 | 3 | 9 | 58 | |
| GSE54994 | GPHN | 10243 | 18 | 5 | 30 | |
| GSE60625 | GPHN | 10243 | 0 | 2 | 9 | |
| GSE74703 | GPHN | 10243 | 7 | 2 | 27 | |
| GSE74704 | GPHN | 10243 | 3 | 2 | 15 | |
| TCGA | GPHN | 10243 | 33 | 19 | 44 |
Total number of gains: 113; Total number of losses: 59; Total Number of normals: 316.
Somatic mutations of GPHN:
Generating mutation plots.
Highly correlated genes for GPHN:
Showing top 20/269 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPHN | C21orf91 | 0.823805 | 3 | 0 | 3 |
| GPHN | PDLIM1 | 0.775625 | 3 | 0 | 3 |
| GPHN | CDK5RAP2 | 0.752793 | 3 | 0 | 3 |
| GPHN | RNF144B | 0.750718 | 3 | 0 | 3 |
| GPHN | MKLN1 | 0.747523 | 3 | 0 | 3 |
| GPHN | FZD1 | 0.745578 | 3 | 0 | 3 |
| GPHN | PLCD3 | 0.742254 | 4 | 0 | 3 |
| GPHN | HSPB11 | 0.741754 | 3 | 0 | 3 |
| GPHN | SCAMP1 | 0.739047 | 3 | 0 | 3 |
| GPHN | MTOR | 0.73565 | 3 | 0 | 3 |
| GPHN | ETFA | 0.729421 | 3 | 0 | 3 |
| GPHN | PLEKHA5 | 0.722604 | 3 | 0 | 3 |
| GPHN | MRPL27 | 0.718521 | 3 | 0 | 3 |
| GPHN | TBCK | 0.718049 | 3 | 0 | 3 |
| GPHN | CUL1 | 0.71751 | 3 | 0 | 3 |
| GPHN | PAN2 | 0.715342 | 3 | 0 | 3 |
| GPHN | TMEM107 | 0.715267 | 3 | 0 | 3 |
| GPHN | UBE2Q2 | 0.705276 | 3 | 0 | 3 |
| GPHN | FAM98B | 0.702222 | 3 | 0 | 3 |
| GPHN | CHCHD3 | 0.701979 | 3 | 0 | 3 |
For details and further investigation, click here
