| Full name: cell division cycle 73 | Alias Symbol: parafibromin|FIHP | ||
| Type: protein-coding gene | Cytoband: 1q31.2 | ||
| Entrez ID: 79577 | HGNC ID: HGNC:16783 | Ensembl Gene: ENSG00000134371 | OMIM ID: 607393 |
| Drug and gene relationship at DGIdb | |||
Expression of CDC73:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDC73 | 79577 | 218578_at | 0.2399 | 0.5183 | |
| GSE20347 | CDC73 | 79577 | 218578_at | 0.1736 | 0.3927 | |
| GSE23400 | CDC73 | 79577 | 218578_at | 0.2551 | 0.0001 | |
| GSE26886 | CDC73 | 79577 | 218578_at | 0.3792 | 0.0763 | |
| GSE29001 | CDC73 | 79577 | 218578_at | 0.0809 | 0.8713 | |
| GSE38129 | CDC73 | 79577 | 218578_at | 0.1922 | 0.2075 | |
| GSE45670 | CDC73 | 79577 | 218578_at | 0.2101 | 0.0983 | |
| GSE53622 | CDC73 | 79577 | 20961 | -0.3614 | 0.0000 | |
| GSE53624 | CDC73 | 79577 | 20961 | -0.3089 | 0.0001 | |
| GSE63941 | CDC73 | 79577 | 218578_at | 0.2073 | 0.6619 | |
| GSE77861 | CDC73 | 79577 | 218578_at | 0.0392 | 0.8583 | |
| GSE97050 | CDC73 | 79577 | A_33_P3219770 | -0.5197 | 0.1754 | |
| SRP007169 | CDC73 | 79577 | RNAseq | 0.2149 | 0.4848 | |
| SRP008496 | CDC73 | 79577 | RNAseq | 0.6274 | 0.0093 | |
| SRP064894 | CDC73 | 79577 | RNAseq | -0.1160 | 0.5963 | |
| SRP133303 | CDC73 | 79577 | RNAseq | 0.0674 | 0.5591 | |
| SRP159526 | CDC73 | 79577 | RNAseq | 0.0240 | 0.9223 | |
| SRP193095 | CDC73 | 79577 | RNAseq | 0.0092 | 0.8918 | |
| SRP219564 | CDC73 | 79577 | RNAseq | -0.1952 | 0.4270 | |
| TCGA | CDC73 | 79577 | RNAseq | 0.0157 | 0.7369 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CDC73 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDC73:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDC73 | 79577 | 9 | 1 | 20 | |
| GSE20123 | CDC73 | 79577 | 9 | 1 | 20 | |
| GSE43470 | CDC73 | 79577 | 5 | 1 | 37 | |
| GSE46452 | CDC73 | 79577 | 3 | 1 | 55 | |
| GSE47630 | CDC73 | 79577 | 14 | 0 | 26 | |
| GSE54993 | CDC73 | 79577 | 0 | 6 | 64 | |
| GSE54994 | CDC73 | 79577 | 15 | 0 | 38 | |
| GSE60625 | CDC73 | 79577 | 0 | 0 | 11 | |
| GSE74703 | CDC73 | 79577 | 5 | 1 | 30 | |
| GSE74704 | CDC73 | 79577 | 3 | 1 | 16 | |
| TCGA | CDC73 | 79577 | 41 | 9 | 46 |
Total number of gains: 104; Total number of losses: 21; Total Number of normals: 363.
Somatic mutations of CDC73:
Generating mutation plots.
Highly correlated genes for CDC73:
Showing top 20/406 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDC73 | ING2 | 0.831379 | 3 | 0 | 3 |
| CDC73 | TIGD1 | 0.803825 | 3 | 0 | 3 |
| CDC73 | UTP3 | 0.799656 | 3 | 0 | 3 |
| CDC73 | ZNF544 | 0.793702 | 3 | 0 | 3 |
| CDC73 | MRPS22 | 0.778093 | 3 | 0 | 3 |
| CDC73 | TADA1 | 0.774897 | 3 | 0 | 3 |
| CDC73 | ZMPSTE24 | 0.773472 | 3 | 0 | 3 |
| CDC73 | COCH | 0.771563 | 3 | 0 | 3 |
| CDC73 | SON | 0.761686 | 3 | 0 | 3 |
| CDC73 | MBD5 | 0.761213 | 3 | 0 | 3 |
| CDC73 | ARFGEF2 | 0.752351 | 3 | 0 | 3 |
| CDC73 | PTPN23 | 0.746141 | 3 | 0 | 3 |
| CDC73 | ZNF766 | 0.74449 | 3 | 0 | 3 |
| CDC73 | SRSF6 | 0.744021 | 3 | 0 | 3 |
| CDC73 | GTF2H5 | 0.73023 | 3 | 0 | 3 |
| CDC73 | CFL2 | 0.72893 | 3 | 0 | 3 |
| CDC73 | ZNF557 | 0.726365 | 3 | 0 | 3 |
| CDC73 | BRWD1 | 0.723971 | 4 | 0 | 4 |
| CDC73 | MTOR | 0.723354 | 3 | 0 | 3 |
| CDC73 | ANAPC13 | 0.720471 | 3 | 0 | 3 |
For details and further investigation, click here
