| Full name: nuclear receptor coactivator 6 | Alias Symbol: KIAA0181|RAP250|ASC2|AIB3|PRIP|TRBP|NRC | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 23054 | HGNC ID: HGNC:15936 | Ensembl Gene: ENSG00000198646 | OMIM ID: 605299 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NCOA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NCOA6 | 23054 | 208979_at | 0.6950 | 0.0886 | |
| GSE20347 | NCOA6 | 23054 | 208979_at | 0.2700 | 0.0123 | |
| GSE23400 | NCOA6 | 23054 | 208979_at | 0.1107 | 0.0726 | |
| GSE26886 | NCOA6 | 23054 | 208979_at | 0.1418 | 0.5913 | |
| GSE29001 | NCOA6 | 23054 | 208979_at | 0.3443 | 0.0234 | |
| GSE38129 | NCOA6 | 23054 | 208979_at | 0.2959 | 0.0004 | |
| GSE45670 | NCOA6 | 23054 | 208979_at | 0.0835 | 0.4877 | |
| GSE53622 | NCOA6 | 23054 | 48286 | 0.1888 | 0.0022 | |
| GSE53624 | NCOA6 | 23054 | 48286 | 0.1502 | 0.0025 | |
| GSE63941 | NCOA6 | 23054 | 208979_at | 0.0664 | 0.8969 | |
| GSE77861 | NCOA6 | 23054 | 208979_at | 0.2895 | 0.2555 | |
| GSE97050 | NCOA6 | 23054 | A_23_P259135 | 0.0155 | 0.9661 | |
| SRP007169 | NCOA6 | 23054 | RNAseq | 0.7345 | 0.0432 | |
| SRP008496 | NCOA6 | 23054 | RNAseq | 0.9926 | 0.0001 | |
| SRP064894 | NCOA6 | 23054 | RNAseq | 0.2211 | 0.3280 | |
| SRP133303 | NCOA6 | 23054 | RNAseq | 0.2637 | 0.0111 | |
| SRP159526 | NCOA6 | 23054 | RNAseq | 0.0476 | 0.7820 | |
| SRP193095 | NCOA6 | 23054 | RNAseq | 0.0531 | 0.6172 | |
| SRP219564 | NCOA6 | 23054 | RNAseq | 0.1845 | 0.5026 | |
| TCGA | NCOA6 | 23054 | RNAseq | 0.0619 | 0.1473 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NCOA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NCOA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NCOA6 | 23054 | 16 | 0 | 14 | |
| GSE20123 | NCOA6 | 23054 | 16 | 0 | 14 | |
| GSE43470 | NCOA6 | 23054 | 12 | 0 | 31 | |
| GSE46452 | NCOA6 | 23054 | 29 | 0 | 30 | |
| GSE47630 | NCOA6 | 23054 | 24 | 1 | 15 | |
| GSE54993 | NCOA6 | 23054 | 0 | 18 | 52 | |
| GSE54994 | NCOA6 | 23054 | 25 | 1 | 27 | |
| GSE60625 | NCOA6 | 23054 | 0 | 0 | 11 | |
| GSE74703 | NCOA6 | 23054 | 11 | 0 | 25 | |
| GSE74704 | NCOA6 | 23054 | 11 | 0 | 9 | |
| TCGA | NCOA6 | 23054 | 49 | 3 | 44 |
Total number of gains: 193; Total number of losses: 23; Total Number of normals: 272.
Somatic mutations of NCOA6:
Generating mutation plots.
Highly correlated genes for NCOA6:
Showing top 20/697 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NCOA6 | NFXL1 | 0.784736 | 3 | 0 | 3 |
| NCOA6 | LCMT1 | 0.775385 | 3 | 0 | 3 |
| NCOA6 | SLC45A4 | 0.769348 | 3 | 0 | 3 |
| NCOA6 | COMMD5 | 0.768636 | 3 | 0 | 3 |
| NCOA6 | WDR5 | 0.766296 | 3 | 0 | 3 |
| NCOA6 | ZNF284 | 0.764484 | 3 | 0 | 3 |
| NCOA6 | THADA | 0.763844 | 3 | 0 | 3 |
| NCOA6 | GRIN2D | 0.763519 | 3 | 0 | 3 |
| NCOA6 | PIP4K2C | 0.759141 | 3 | 0 | 3 |
| NCOA6 | MPHOSPH9 | 0.749714 | 3 | 0 | 3 |
| NCOA6 | ALMS1 | 0.74876 | 3 | 0 | 3 |
| NCOA6 | SOCS7 | 0.742952 | 3 | 0 | 3 |
| NCOA6 | GDI1 | 0.741768 | 3 | 0 | 3 |
| NCOA6 | CCM2 | 0.740673 | 3 | 0 | 3 |
| NCOA6 | PPHLN1 | 0.738858 | 3 | 0 | 3 |
| NCOA6 | SFSWAP | 0.737513 | 3 | 0 | 3 |
| NCOA6 | TMEM86B | 0.736633 | 3 | 0 | 3 |
| NCOA6 | RRM2B | 0.736379 | 3 | 0 | 3 |
| NCOA6 | HS6ST1 | 0.736181 | 3 | 0 | 3 |
| NCOA6 | CMIP | 0.736087 | 3 | 0 | 3 |
For details and further investigation, click here
