| Full name: farnesyltransferase, CAAX box, alpha | Alias Symbol: FPTA|PGGT1A|PTAR2 | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 2339 | HGNC ID: HGNC:3782 | Ensembl Gene: ENSG00000168522 | OMIM ID: 134635 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FNTA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FNTA | 2339 | 200090_at | 0.1525 | 0.5913 | |
| GSE20347 | FNTA | 2339 | 200090_at | 0.1877 | 0.0925 | |
| GSE23400 | FNTA | 2339 | 200090_at | 0.4061 | 0.0000 | |
| GSE26886 | FNTA | 2339 | 200090_at | -0.2800 | 0.1431 | |
| GSE29001 | FNTA | 2339 | 200090_at | 0.4420 | 0.0316 | |
| GSE38129 | FNTA | 2339 | 200090_at | 0.2243 | 0.0218 | |
| GSE45670 | FNTA | 2339 | 200090_at | 0.1504 | 0.1370 | |
| GSE53622 | FNTA | 2339 | 19738 | 0.0831 | 0.3116 | |
| GSE53624 | FNTA | 2339 | 30053 | 0.3434 | 0.0000 | |
| GSE63941 | FNTA | 2339 | 200090_at | -0.0745 | 0.8852 | |
| GSE77861 | FNTA | 2339 | 200090_at | 0.1999 | 0.4894 | |
| GSE97050 | FNTA | 2339 | A_23_P24926 | 0.1282 | 0.6553 | |
| SRP007169 | FNTA | 2339 | RNAseq | 0.0452 | 0.9162 | |
| SRP008496 | FNTA | 2339 | RNAseq | 0.0147 | 0.9525 | |
| SRP064894 | FNTA | 2339 | RNAseq | 0.1802 | 0.3407 | |
| SRP133303 | FNTA | 2339 | RNAseq | 0.1638 | 0.4423 | |
| SRP159526 | FNTA | 2339 | RNAseq | -0.4296 | 0.1206 | |
| SRP193095 | FNTA | 2339 | RNAseq | -0.2099 | 0.1454 | |
| SRP219564 | FNTA | 2339 | RNAseq | -0.3481 | 0.1274 | |
| TCGA | FNTA | 2339 | RNAseq | 0.1170 | 0.0359 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FNTA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FNTA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FNTA | 2339 | 10 | 4 | 16 | |
| GSE20123 | FNTA | 2339 | 10 | 4 | 16 | |
| GSE43470 | FNTA | 2339 | 8 | 6 | 29 | |
| GSE46452 | FNTA | 2339 | 20 | 5 | 34 | |
| GSE47630 | FNTA | 2339 | 22 | 1 | 17 | |
| GSE54993 | FNTA | 2339 | 1 | 16 | 53 | |
| GSE54994 | FNTA | 2339 | 18 | 8 | 27 | |
| GSE60625 | FNTA | 2339 | 3 | 0 | 8 | |
| GSE74703 | FNTA | 2339 | 7 | 5 | 24 | |
| GSE74704 | FNTA | 2339 | 9 | 1 | 10 | |
| TCGA | FNTA | 2339 | 47 | 17 | 32 |
Total number of gains: 155; Total number of losses: 67; Total Number of normals: 266.
Somatic mutations of FNTA:
Generating mutation plots.
Highly correlated genes for FNTA:
Showing top 20/566 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FNTA | STX10 | 0.821544 | 3 | 0 | 3 |
| FNTA | EIF2S3 | 0.79902 | 3 | 0 | 3 |
| FNTA | ZMPSTE24 | 0.790974 | 3 | 0 | 3 |
| FNTA | MTOR | 0.772524 | 3 | 0 | 3 |
| FNTA | RAD18 | 0.755185 | 3 | 0 | 3 |
| FNTA | PSMC1 | 0.75352 | 3 | 0 | 3 |
| FNTA | SRI | 0.749887 | 3 | 0 | 3 |
| FNTA | AIDA | 0.743176 | 3 | 0 | 3 |
| FNTA | NEIL2 | 0.742178 | 3 | 0 | 3 |
| FNTA | COMMD2 | 0.741653 | 4 | 0 | 3 |
| FNTA | POLR3C | 0.733923 | 3 | 0 | 3 |
| FNTA | KIAA1324L | 0.730138 | 3 | 0 | 3 |
| FNTA | ARFGEF2 | 0.726936 | 4 | 0 | 3 |
| FNTA | CSTF2T | 0.722009 | 3 | 0 | 3 |
| FNTA | TMEM38B | 0.720915 | 3 | 0 | 3 |
| FNTA | GET4 | 0.71992 | 3 | 0 | 3 |
| FNTA | DNTTIP1 | 0.713657 | 3 | 0 | 3 |
| FNTA | RALGAPB | 0.713511 | 3 | 0 | 3 |
| FNTA | GOLGA7 | 0.71276 | 11 | 0 | 10 |
| FNTA | SDCBP | 0.71229 | 4 | 0 | 4 |
For details and further investigation, click here
