| Full name: tRNA splicing endonuclease subunit 15 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 116461 | HGNC ID: HGNC:16791 | Ensembl Gene: ENSG00000198860 | OMIM ID: 608756 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TSEN15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TSEN15 | 116461 | 225399_at | 0.9609 | 0.0207 | |
| GSE26886 | TSEN15 | 116461 | 225399_at | 0.7077 | 0.0028 | |
| GSE45670 | TSEN15 | 116461 | 225399_at | 0.4445 | 0.0191 | |
| GSE53622 | TSEN15 | 116461 | 119410 | 0.4723 | 0.0000 | |
| GSE53624 | TSEN15 | 116461 | 119410 | 0.8348 | 0.0000 | |
| GSE63941 | TSEN15 | 116461 | 225399_at | 0.4083 | 0.4980 | |
| GSE77861 | TSEN15 | 116461 | 230257_s_at | 0.2983 | 0.1547 | |
| GSE97050 | TSEN15 | 116461 | A_23_P104025 | 0.3587 | 0.2438 | |
| SRP007169 | TSEN15 | 116461 | RNAseq | 0.4247 | 0.2330 | |
| SRP008496 | TSEN15 | 116461 | RNAseq | 1.0167 | 0.0006 | |
| SRP064894 | TSEN15 | 116461 | RNAseq | 0.5695 | 0.0000 | |
| SRP133303 | TSEN15 | 116461 | RNAseq | 0.5967 | 0.0000 | |
| SRP159526 | TSEN15 | 116461 | RNAseq | 1.4122 | 0.0000 | |
| SRP193095 | TSEN15 | 116461 | RNAseq | 0.4166 | 0.0000 | |
| SRP219564 | TSEN15 | 116461 | RNAseq | 0.6432 | 0.0860 | |
| TCGA | TSEN15 | 116461 | RNAseq | 0.2296 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TSEN15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TSEN15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TSEN15 | 116461 | 12 | 0 | 18 | |
| GSE20123 | TSEN15 | 116461 | 12 | 0 | 18 | |
| GSE43470 | TSEN15 | 116461 | 7 | 1 | 35 | |
| GSE46452 | TSEN15 | 116461 | 3 | 1 | 55 | |
| GSE47630 | TSEN15 | 116461 | 14 | 0 | 26 | |
| GSE54993 | TSEN15 | 116461 | 0 | 6 | 64 | |
| GSE54994 | TSEN15 | 116461 | 15 | 0 | 38 | |
| GSE60625 | TSEN15 | 116461 | 0 | 0 | 11 | |
| GSE74703 | TSEN15 | 116461 | 7 | 1 | 28 | |
| GSE74704 | TSEN15 | 116461 | 5 | 0 | 15 | |
| TCGA | TSEN15 | 116461 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of TSEN15:
Generating mutation plots.
Highly correlated genes for TSEN15:
Showing top 20/1569 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TSEN15 | FZD6 | 0.795243 | 4 | 0 | 4 |
| TSEN15 | PCGF6 | 0.788934 | 3 | 0 | 3 |
| TSEN15 | CLCN7 | 0.77369 | 3 | 0 | 3 |
| TSEN15 | MCMBP | 0.771467 | 3 | 0 | 3 |
| TSEN15 | CDC37 | 0.767818 | 3 | 0 | 3 |
| TSEN15 | SCNM1 | 0.759961 | 3 | 0 | 3 |
| TSEN15 | GUSB | 0.759411 | 3 | 0 | 3 |
| TSEN15 | HNRNPAB | 0.754849 | 4 | 0 | 3 |
| TSEN15 | CERS2 | 0.754757 | 4 | 0 | 4 |
| TSEN15 | CACYBP | 0.752989 | 6 | 0 | 6 |
| TSEN15 | IGF2R | 0.750048 | 4 | 0 | 4 |
| TSEN15 | RPS21 | 0.746923 | 3 | 0 | 3 |
| TSEN15 | PYCR2 | 0.74649 | 3 | 0 | 3 |
| TSEN15 | KIAA0100 | 0.741992 | 3 | 0 | 3 |
| TSEN15 | FADS1 | 0.74144 | 3 | 0 | 3 |
| TSEN15 | CMTM4 | 0.738518 | 3 | 0 | 3 |
| TSEN15 | TET1 | 0.7378 | 3 | 0 | 3 |
| TSEN15 | DAPK3 | 0.737165 | 3 | 0 | 3 |
| TSEN15 | GORAB | 0.735694 | 7 | 0 | 7 |
| TSEN15 | GNB1 | 0.733159 | 3 | 0 | 3 |
For details and further investigation, click here
