| Full name: mevalonate diphosphate decarboxylase | Alias Symbol: MPD | ||
| Type: protein-coding gene | Cytoband: 16q24.2 | ||
| Entrez ID: 4597 | HGNC ID: HGNC:7529 | Ensembl Gene: ENSG00000167508 | OMIM ID: 603236 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MVD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MVD | 4597 | 203027_s_at | 0.0807 | 0.8938 | |
| GSE20347 | MVD | 4597 | 203027_s_at | -0.2106 | 0.0165 | |
| GSE23400 | MVD | 4597 | 203027_s_at | -0.1049 | 0.0506 | |
| GSE26886 | MVD | 4597 | 203027_s_at | -0.3175 | 0.0442 | |
| GSE29001 | MVD | 4597 | 203027_s_at | -0.2523 | 0.0639 | |
| GSE38129 | MVD | 4597 | 203027_s_at | 0.0103 | 0.9397 | |
| GSE45670 | MVD | 4597 | 203027_s_at | 0.1695 | 0.1104 | |
| GSE53622 | MVD | 4597 | 87044 | -0.1703 | 0.0046 | |
| GSE53624 | MVD | 4597 | 87044 | -0.2423 | 0.0006 | |
| GSE63941 | MVD | 4597 | 203027_s_at | 0.7531 | 0.0115 | |
| GSE77861 | MVD | 4597 | 203027_s_at | -0.0837 | 0.6837 | |
| GSE97050 | MVD | 4597 | A_23_P152125 | -0.1879 | 0.4469 | |
| SRP007169 | MVD | 4597 | RNAseq | -0.3182 | 0.5668 | |
| SRP064894 | MVD | 4597 | RNAseq | -0.1509 | 0.6436 | |
| SRP133303 | MVD | 4597 | RNAseq | 0.0470 | 0.8689 | |
| SRP159526 | MVD | 4597 | RNAseq | 0.1865 | 0.6815 | |
| SRP193095 | MVD | 4597 | RNAseq | -0.2552 | 0.1359 | |
| SRP219564 | MVD | 4597 | RNAseq | -0.5389 | 0.1528 | |
| TCGA | MVD | 4597 | RNAseq | 0.0898 | 0.2812 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MVD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MVD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MVD | 4597 | 4 | 3 | 23 | |
| GSE20123 | MVD | 4597 | 4 | 3 | 23 | |
| GSE43470 | MVD | 4597 | 1 | 13 | 29 | |
| GSE46452 | MVD | 4597 | 38 | 1 | 20 | |
| GSE47630 | MVD | 4597 | 11 | 9 | 20 | |
| GSE54993 | MVD | 4597 | 3 | 4 | 63 | |
| GSE54994 | MVD | 4597 | 9 | 11 | 33 | |
| GSE60625 | MVD | 4597 | 4 | 0 | 7 | |
| GSE74703 | MVD | 4597 | 1 | 9 | 26 | |
| GSE74704 | MVD | 4597 | 3 | 2 | 15 | |
| TCGA | MVD | 4597 | 28 | 15 | 53 |
Total number of gains: 106; Total number of losses: 70; Total Number of normals: 312.
Somatic mutations of MVD:
Generating mutation plots.
Highly correlated genes for MVD:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MVD | PEX11G | 0.799322 | 3 | 0 | 3 |
| MVD | JSRP1 | 0.764828 | 3 | 0 | 3 |
| MVD | TULP1 | 0.731162 | 4 | 0 | 4 |
| MVD | SLC5A10 | 0.729367 | 4 | 0 | 3 |
| MVD | VCX2 | 0.716699 | 5 | 0 | 5 |
| MVD | VPS33B | 0.705998 | 3 | 0 | 3 |
| MVD | NXNL1 | 0.6999 | 3 | 0 | 3 |
| MVD | PPP1R3F | 0.696701 | 4 | 0 | 3 |
| MVD | SPN | 0.686531 | 3 | 0 | 3 |
| MVD | HTR6 | 0.670136 | 3 | 0 | 3 |
| MVD | LRCH4 | 0.669895 | 5 | 0 | 4 |
| MVD | C8orf74 | 0.667677 | 3 | 0 | 3 |
| MVD | NPR1 | 0.66569 | 4 | 0 | 4 |
| MVD | PCSK4 | 0.662988 | 4 | 0 | 3 |
| MVD | REG3A | 0.658598 | 4 | 0 | 3 |
| MVD | ANKFN1 | 0.653215 | 3 | 0 | 3 |
| MVD | LRFN2 | 0.65263 | 5 | 0 | 4 |
| MVD | NT5C1A | 0.651506 | 4 | 0 | 3 |
| MVD | PAOX | 0.651425 | 4 | 0 | 3 |
| MVD | TRIM17 | 0.649382 | 4 | 0 | 3 |
For details and further investigation, click here
