| Full name: leucine rich repeats and calponin homology domain containing 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 4034 | HGNC ID: HGNC:6691 | Ensembl Gene: ENSG00000077454 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of LRCH4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRCH4 | 4034 | 90610_at | 0.0595 | 0.9373 | |
| GSE20347 | LRCH4 | 4034 | 90610_at | -0.3332 | 0.0005 | |
| GSE23400 | LRCH4 | 4034 | 90610_at | -0.2439 | 0.0000 | |
| GSE26886 | LRCH4 | 4034 | 90610_at | 0.3237 | 0.0544 | |
| GSE29001 | LRCH4 | 4034 | 90610_at | -0.4073 | 0.0848 | |
| GSE38129 | LRCH4 | 4034 | 90610_at | -0.2760 | 0.0016 | |
| GSE45670 | LRCH4 | 4034 | 90610_at | -0.1638 | 0.1451 | |
| GSE63941 | LRCH4 | 4034 | 90610_at | -0.0796 | 0.7415 | |
| GSE77861 | LRCH4 | 4034 | 221956_at | -0.1002 | 0.6812 | |
| GSE97050 | LRCH4 | 4034 | A_33_P3396200 | -0.2366 | 0.3112 | |
| SRP007169 | LRCH4 | 4034 | RNAseq | -1.7646 | 0.0001 | |
| SRP008496 | LRCH4 | 4034 | RNAseq | -2.0441 | 0.0000 | |
| SRP064894 | LRCH4 | 4034 | RNAseq | -0.5082 | 0.0000 | |
| SRP133303 | LRCH4 | 4034 | RNAseq | -0.5957 | 0.0001 | |
| SRP159526 | LRCH4 | 4034 | RNAseq | -0.7889 | 0.0000 | |
| SRP193095 | LRCH4 | 4034 | RNAseq | -0.1211 | 0.5489 | |
| SRP219564 | LRCH4 | 4034 | RNAseq | -0.2432 | 0.4043 | |
| TCGA | LRCH4 | 4034 | RNAseq | -0.0297 | 0.5903 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LRCH4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LRCH4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRCH4 | 4034 | 13 | 0 | 17 | |
| GSE20123 | LRCH4 | 4034 | 13 | 0 | 17 | |
| GSE43470 | LRCH4 | 4034 | 7 | 2 | 34 | |
| GSE46452 | LRCH4 | 4034 | 11 | 1 | 47 | |
| GSE47630 | LRCH4 | 4034 | 7 | 3 | 30 | |
| GSE54993 | LRCH4 | 4034 | 1 | 9 | 60 | |
| GSE54994 | LRCH4 | 4034 | 16 | 3 | 34 | |
| GSE60625 | LRCH4 | 4034 | 0 | 0 | 11 | |
| GSE74703 | LRCH4 | 4034 | 7 | 1 | 28 | |
| GSE74704 | LRCH4 | 4034 | 9 | 0 | 11 | |
| TCGA | LRCH4 | 4034 | 53 | 6 | 37 |
Total number of gains: 137; Total number of losses: 25; Total Number of normals: 326.
Somatic mutations of LRCH4:
Generating mutation plots.
Highly correlated genes for LRCH4:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRCH4 | MAP3K10 | 0.877315 | 3 | 0 | 3 |
| LRCH4 | SYT2 | 0.802381 | 3 | 0 | 3 |
| LRCH4 | SLC6A13 | 0.795695 | 3 | 0 | 3 |
| LRCH4 | PGC | 0.795012 | 3 | 0 | 3 |
| LRCH4 | AMHR2 | 0.78346 | 3 | 0 | 3 |
| LRCH4 | CCNJL | 0.775556 | 3 | 0 | 3 |
| LRCH4 | RASL10B | 0.773698 | 3 | 0 | 3 |
| LRCH4 | C11orf86 | 0.773548 | 3 | 0 | 3 |
| LRCH4 | FAM181A | 0.762585 | 3 | 0 | 3 |
| LRCH4 | FASTK | 0.760485 | 3 | 0 | 3 |
| LRCH4 | CNTD2 | 0.758632 | 3 | 0 | 3 |
| LRCH4 | TIGD5 | 0.752288 | 3 | 0 | 3 |
| LRCH4 | MYOD1 | 0.74436 | 3 | 0 | 3 |
| LRCH4 | TMUB1 | 0.741791 | 3 | 0 | 3 |
| LRCH4 | ARVCF | 0.733813 | 4 | 0 | 4 |
| LRCH4 | EYS | 0.730153 | 4 | 0 | 3 |
| LRCH4 | ZSWIM3 | 0.729811 | 3 | 0 | 3 |
| LRCH4 | LIMD1 | 0.729099 | 3 | 0 | 3 |
| LRCH4 | SPRED3 | 0.727464 | 3 | 0 | 3 |
| LRCH4 | VCX2 | 0.725579 | 4 | 0 | 4 |
For details and further investigation, click here
