| Full name: 5-hydroxytryptamine receptor 6 | Alias Symbol: 5-HT6|5-HT6R | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 3362 | HGNC ID: HGNC:5301 | Ensembl Gene: ENSG00000158748 | OMIM ID: 601109 |
| Drug and gene relationship at DGIdb | |||
HTR6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04726 | Serotonergic synapse |
Expression of HTR6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR6 | 3362 | 206944_at | 0.0745 | 0.6975 | |
| GSE20347 | HTR6 | 3362 | 206944_at | 0.0511 | 0.5665 | |
| GSE23400 | HTR6 | 3362 | 206944_at | -0.0109 | 0.7434 | |
| GSE26886 | HTR6 | 3362 | 206944_at | 0.2588 | 0.0392 | |
| GSE29001 | HTR6 | 3362 | 206944_at | -0.1404 | 0.3223 | |
| GSE38129 | HTR6 | 3362 | 206944_at | -0.1122 | 0.2595 | |
| GSE45670 | HTR6 | 3362 | 206944_at | 0.0438 | 0.6212 | |
| GSE53622 | HTR6 | 3362 | 88774 | 0.0995 | 0.1635 | |
| GSE53624 | HTR6 | 3362 | 88774 | 0.1444 | 0.1117 | |
| GSE63941 | HTR6 | 3362 | 206944_at | 0.2271 | 0.3287 | |
| GSE77861 | HTR6 | 3362 | 206944_at | -0.0598 | 0.3930 | |
| GSE97050 | HTR6 | 3362 | A_33_P3345016 | 0.0047 | 0.9925 | |
| SRP133303 | HTR6 | 3362 | RNAseq | -1.4149 | 0.0000 | |
| TCGA | HTR6 | 3362 | RNAseq | 0.7730 | 0.1998 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by HTR6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR6 | 3362 | 0 | 5 | 25 | |
| GSE20123 | HTR6 | 3362 | 0 | 4 | 26 | |
| GSE43470 | HTR6 | 3362 | 0 | 8 | 35 | |
| GSE46452 | HTR6 | 3362 | 5 | 1 | 53 | |
| GSE47630 | HTR6 | 3362 | 8 | 3 | 29 | |
| GSE54993 | HTR6 | 3362 | 3 | 1 | 66 | |
| GSE54994 | HTR6 | 3362 | 11 | 4 | 38 | |
| GSE60625 | HTR6 | 3362 | 0 | 0 | 11 | |
| GSE74703 | HTR6 | 3362 | 0 | 5 | 31 | |
| GSE74704 | HTR6 | 3362 | 0 | 0 | 20 | |
| TCGA | HTR6 | 3362 | 10 | 22 | 64 |
Total number of gains: 37; Total number of losses: 53; Total Number of normals: 398.
Somatic mutations of HTR6:
Generating mutation plots.
Highly correlated genes for HTR6:
Showing top 20/1060 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR6 | NXNL1 | 0.841258 | 3 | 0 | 3 |
| HTR6 | CFC1 | 0.781312 | 3 | 0 | 3 |
| HTR6 | BSX | 0.762347 | 3 | 0 | 3 |
| HTR6 | HOXB6 | 0.751581 | 3 | 0 | 3 |
| HTR6 | CCDC151 | 0.738199 | 3 | 0 | 3 |
| HTR6 | DUSP9 | 0.732256 | 4 | 0 | 4 |
| HTR6 | NKX2-3 | 0.723551 | 3 | 0 | 3 |
| HTR6 | CLCNKA | 0.723143 | 3 | 0 | 3 |
| HTR6 | BEST3 | 0.720152 | 3 | 0 | 3 |
| HTR6 | KCTD19 | 0.716038 | 3 | 0 | 3 |
| HTR6 | C1QTNF1 | 0.71101 | 3 | 0 | 3 |
| HTR6 | C1QTNF6 | 0.709219 | 3 | 0 | 3 |
| HTR6 | TUBGCP6 | 0.706669 | 3 | 0 | 3 |
| HTR6 | SPATA2L | 0.705528 | 3 | 0 | 3 |
| HTR6 | ALAS2 | 0.69499 | 4 | 0 | 3 |
| HTR6 | MRGPRG | 0.693115 | 3 | 0 | 3 |
| HTR6 | CAMK1G | 0.692247 | 3 | 0 | 3 |
| HTR6 | ABCA4 | 0.689364 | 4 | 0 | 4 |
| HTR6 | FOLH1 | 0.688715 | 5 | 0 | 5 |
| HTR6 | ZNF527 | 0.687619 | 3 | 0 | 3 |
For details and further investigation, click here
