| Full name: natriuretic peptide receptor 1 | Alias Symbol: GUCY2A|ANPa | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 4881 | HGNC ID: HGNC:7943 | Ensembl Gene: ENSG00000169418 | OMIM ID: 108960 |
| Drug and gene relationship at DGIdb | |||
NPR1 involved pathways:
Expression of NPR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPR1 | 4881 | 204648_at | -0.2275 | 0.3578 | |
| GSE20347 | NPR1 | 4881 | 204648_at | -0.0767 | 0.4669 | |
| GSE23400 | NPR1 | 4881 | 32625_at | -0.3282 | 0.0000 | |
| GSE26886 | NPR1 | 4881 | 204648_at | 0.2063 | 0.1324 | |
| GSE29001 | NPR1 | 4881 | 204648_at | -0.2191 | 0.1312 | |
| GSE38129 | NPR1 | 4881 | 204648_at | -0.3254 | 0.0012 | |
| GSE45670 | NPR1 | 4881 | 204648_at | -0.2437 | 0.0031 | |
| GSE53622 | NPR1 | 4881 | 98784 | -0.6649 | 0.0000 | |
| GSE53624 | NPR1 | 4881 | 98784 | -0.3540 | 0.0000 | |
| GSE63941 | NPR1 | 4881 | 204648_at | 0.3122 | 0.0323 | |
| GSE77861 | NPR1 | 4881 | 204648_at | -0.1750 | 0.1450 | |
| GSE97050 | NPR1 | 4881 | A_23_P147711 | -0.1470 | 0.6554 | |
| SRP007169 | NPR1 | 4881 | RNAseq | -0.2217 | 0.7543 | |
| SRP064894 | NPR1 | 4881 | RNAseq | 0.0414 | 0.9268 | |
| SRP133303 | NPR1 | 4881 | RNAseq | -1.1745 | 0.0047 | |
| SRP159526 | NPR1 | 4881 | RNAseq | -0.8726 | 0.0316 | |
| SRP193095 | NPR1 | 4881 | RNAseq | 0.6065 | 0.0428 | |
| SRP219564 | NPR1 | 4881 | RNAseq | 0.2577 | 0.7133 | |
| TCGA | NPR1 | 4881 | RNAseq | -1.0616 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by NPR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPR1 | 4881 | 14 | 0 | 16 | |
| GSE20123 | NPR1 | 4881 | 14 | 0 | 16 | |
| GSE43470 | NPR1 | 4881 | 7 | 2 | 34 | |
| GSE46452 | NPR1 | 4881 | 2 | 1 | 56 | |
| GSE47630 | NPR1 | 4881 | 14 | 0 | 26 | |
| GSE54993 | NPR1 | 4881 | 0 | 4 | 66 | |
| GSE54994 | NPR1 | 4881 | 16 | 0 | 37 | |
| GSE60625 | NPR1 | 4881 | 0 | 0 | 11 | |
| GSE74703 | NPR1 | 4881 | 6 | 1 | 29 | |
| GSE74704 | NPR1 | 4881 | 7 | 0 | 13 | |
| TCGA | NPR1 | 4881 | 38 | 3 | 55 |
Total number of gains: 118; Total number of losses: 11; Total Number of normals: 359.
Somatic mutations of NPR1:
Generating mutation plots.
Highly correlated genes for NPR1:
Showing top 20/1020 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPR1 | JSRP1 | 0.739346 | 4 | 0 | 4 |
| NPR1 | MOB2 | 0.730303 | 4 | 0 | 4 |
| NPR1 | MEF2C-AS1 | 0.726649 | 3 | 0 | 3 |
| NPR1 | PLAC9 | 0.718336 | 5 | 0 | 5 |
| NPR1 | SPACA3 | 0.711214 | 3 | 0 | 3 |
| NPR1 | CABP7 | 0.710464 | 3 | 0 | 3 |
| NPR1 | RIMS4 | 0.703087 | 4 | 0 | 4 |
| NPR1 | STX1B | 0.70091 | 4 | 0 | 4 |
| NPR1 | TMEM63A | 0.699935 | 3 | 0 | 3 |
| NPR1 | LINC00598 | 0.690571 | 4 | 0 | 4 |
| NPR1 | FOXA3 | 0.690132 | 3 | 0 | 3 |
| NPR1 | HRCT1 | 0.688808 | 3 | 0 | 3 |
| NPR1 | F2 | 0.67851 | 5 | 0 | 4 |
| NPR1 | GIPC3 | 0.678467 | 4 | 0 | 4 |
| NPR1 | BEAN1 | 0.673536 | 4 | 0 | 4 |
| NPR1 | SEC14L1 | 0.672653 | 3 | 0 | 3 |
| NPR1 | UFSP1 | 0.671437 | 3 | 0 | 3 |
| NPR1 | GPR146 | 0.671128 | 4 | 0 | 3 |
| NPR1 | NRIP2 | 0.670968 | 8 | 0 | 8 |
| NPR1 | OR4D2 | 0.669923 | 3 | 0 | 3 |
For details and further investigation, click here
