| Full name: proprotein convertase subtilisin/kexin type 4 | Alias Symbol: PC4|SPC5|DKFZp434B217|MGC34749 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 54760 | HGNC ID: HGNC:8746 | Ensembl Gene: ENSG00000115257 | OMIM ID: 600487 |
| Drug and gene relationship at DGIdb | |||
Expression of PCSK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCSK4 | 54760 | 230901_x_at | -0.0561 | 0.8303 | |
| GSE26886 | PCSK4 | 54760 | 230901_x_at | 0.1628 | 0.1842 | |
| GSE45670 | PCSK4 | 54760 | 230901_x_at | -0.0004 | 0.9971 | |
| GSE53622 | PCSK4 | 54760 | 15323 | 0.0388 | 0.6815 | |
| GSE53624 | PCSK4 | 54760 | 15323 | -0.4137 | 0.0000 | |
| GSE63941 | PCSK4 | 54760 | 230901_x_at | 0.1153 | 0.4506 | |
| GSE77861 | PCSK4 | 54760 | 230901_x_at | -0.0153 | 0.9366 | |
| GSE97050 | PCSK4 | 54760 | A_33_P3247988 | -0.0904 | 0.7176 | |
| SRP064894 | PCSK4 | 54760 | RNAseq | 1.4436 | 0.0023 | |
| SRP133303 | PCSK4 | 54760 | RNAseq | -0.2916 | 0.3913 | |
| SRP159526 | PCSK4 | 54760 | RNAseq | 0.4638 | 0.3422 | |
| SRP219564 | PCSK4 | 54760 | RNAseq | 1.1998 | 0.1245 | |
| TCGA | PCSK4 | 54760 | RNAseq | -0.1591 | 0.5038 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PCSK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCSK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCSK4 | 54760 | 4 | 6 | 20 | |
| GSE20123 | PCSK4 | 54760 | 4 | 5 | 21 | |
| GSE43470 | PCSK4 | 54760 | 1 | 11 | 31 | |
| GSE46452 | PCSK4 | 54760 | 47 | 1 | 11 | |
| GSE47630 | PCSK4 | 54760 | 5 | 7 | 28 | |
| GSE54993 | PCSK4 | 54760 | 16 | 3 | 51 | |
| GSE54994 | PCSK4 | 54760 | 8 | 15 | 30 | |
| GSE60625 | PCSK4 | 54760 | 9 | 0 | 2 | |
| GSE74703 | PCSK4 | 54760 | 1 | 8 | 27 | |
| GSE74704 | PCSK4 | 54760 | 3 | 3 | 14 | |
| TCGA | PCSK4 | 54760 | 6 | 25 | 65 |
Total number of gains: 104; Total number of losses: 84; Total Number of normals: 300.
Somatic mutations of PCSK4:
Generating mutation plots.
Highly correlated genes for PCSK4:
Showing top 20/337 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCSK4 | PLA2G2C | 0.731858 | 3 | 0 | 3 |
| PCSK4 | NPM2 | 0.713622 | 4 | 0 | 3 |
| PCSK4 | ANO2 | 0.701379 | 3 | 0 | 3 |
| PCSK4 | CLRN2 | 0.690795 | 3 | 0 | 3 |
| PCSK4 | GPR62 | 0.689114 | 3 | 0 | 3 |
| PCSK4 | DUSP9 | 0.687143 | 3 | 0 | 3 |
| PCSK4 | SIGLEC7 | 0.685977 | 3 | 0 | 3 |
| PCSK4 | FBRSL1 | 0.680516 | 3 | 0 | 3 |
| PCSK4 | KIF17 | 0.678678 | 4 | 0 | 3 |
| PCSK4 | TEX13A | 0.678611 | 5 | 0 | 5 |
| PCSK4 | STRC | 0.678227 | 3 | 0 | 3 |
| PCSK4 | SEZ6L2 | 0.671776 | 3 | 0 | 3 |
| PCSK4 | FMR1NB | 0.670534 | 4 | 0 | 3 |
| PCSK4 | TMUB1 | 0.6675 | 3 | 0 | 3 |
| PCSK4 | MGAT5B | 0.667419 | 5 | 0 | 5 |
| PCSK4 | ARMC5 | 0.663198 | 5 | 0 | 4 |
| PCSK4 | MVD | 0.662988 | 4 | 0 | 3 |
| PCSK4 | COL20A1 | 0.660587 | 5 | 0 | 4 |
| PCSK4 | ZIC1 | 0.657573 | 3 | 0 | 3 |
| PCSK4 | ARL4D | 0.656063 | 3 | 0 | 3 |
For details and further investigation, click here
