| Full name: MAX interactor 1, dimerization protein | Alias Symbol: MXD2|MAD2|MXI|bHLHc11 | ||
| Type: protein-coding gene | Cytoband: 10q25.2 | ||
| Entrez ID: 4601 | HGNC ID: HGNC:7534 | Ensembl Gene: ENSG00000119950 | OMIM ID: 600020 |
| Drug and gene relationship at DGIdb | |||
Expression of MXI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MXI1 | 4601 | 202364_at | -0.9373 | 0.0908 | |
| GSE20347 | MXI1 | 4601 | 202364_at | -0.7474 | 0.0017 | |
| GSE23400 | MXI1 | 4601 | 202364_at | -0.6500 | 0.0000 | |
| GSE26886 | MXI1 | 4601 | 202364_at | -0.9569 | 0.0000 | |
| GSE29001 | MXI1 | 4601 | 202364_at | -0.9291 | 0.0050 | |
| GSE38129 | MXI1 | 4601 | 202364_at | -0.8496 | 0.0000 | |
| GSE45670 | MXI1 | 4601 | 202364_at | -0.7844 | 0.0010 | |
| GSE53622 | MXI1 | 4601 | 142863 | -1.0217 | 0.0000 | |
| GSE53624 | MXI1 | 4601 | 142863 | -1.0660 | 0.0000 | |
| GSE63941 | MXI1 | 4601 | 202364_at | -0.5085 | 0.4841 | |
| GSE77861 | MXI1 | 4601 | 202364_at | -0.5778 | 0.1079 | |
| GSE97050 | MXI1 | 4601 | A_33_P3383029 | -0.7862 | 0.1481 | |
| SRP007169 | MXI1 | 4601 | RNAseq | -2.2351 | 0.0000 | |
| SRP008496 | MXI1 | 4601 | RNAseq | -2.2653 | 0.0000 | |
| SRP064894 | MXI1 | 4601 | RNAseq | -0.9973 | 0.0000 | |
| SRP133303 | MXI1 | 4601 | RNAseq | -0.7437 | 0.0000 | |
| SRP159526 | MXI1 | 4601 | RNAseq | -0.7846 | 0.0249 | |
| SRP193095 | MXI1 | 4601 | RNAseq | -1.1035 | 0.0000 | |
| SRP219564 | MXI1 | 4601 | RNAseq | -0.9946 | 0.0875 | |
| TCGA | MXI1 | 4601 | RNAseq | -0.2181 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by MXI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MXI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MXI1 | 4601 | 1 | 10 | 19 | |
| GSE20123 | MXI1 | 4601 | 1 | 9 | 20 | |
| GSE43470 | MXI1 | 4601 | 0 | 7 | 36 | |
| GSE46452 | MXI1 | 4601 | 0 | 11 | 48 | |
| GSE47630 | MXI1 | 4601 | 2 | 14 | 24 | |
| GSE54993 | MXI1 | 4601 | 8 | 0 | 62 | |
| GSE54994 | MXI1 | 4601 | 1 | 10 | 42 | |
| GSE60625 | MXI1 | 4601 | 0 | 0 | 11 | |
| GSE74703 | MXI1 | 4601 | 0 | 5 | 31 | |
| GSE74704 | MXI1 | 4601 | 1 | 4 | 15 | |
| TCGA | MXI1 | 4601 | 4 | 28 | 64 |
Total number of gains: 18; Total number of losses: 98; Total Number of normals: 372.
Somatic mutations of MXI1:
Generating mutation plots.
Highly correlated genes for MXI1:
Showing top 20/1453 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MXI1 | HDHD2 | 0.791022 | 4 | 0 | 4 |
| MXI1 | SLC35D2 | 0.766275 | 3 | 0 | 3 |
| MXI1 | USP9Y | 0.746166 | 3 | 0 | 3 |
| MXI1 | ANO8 | 0.740904 | 3 | 0 | 3 |
| MXI1 | EIF4E3 | 0.740158 | 7 | 0 | 7 |
| MXI1 | USP54 | 0.73871 | 7 | 0 | 7 |
| MXI1 | SH3D19 | 0.738668 | 5 | 0 | 5 |
| MXI1 | SNCA | 0.73833 | 3 | 0 | 3 |
| MXI1 | CNKSR3 | 0.730246 | 7 | 0 | 6 |
| MXI1 | RBPMS-AS1 | 0.726733 | 3 | 0 | 3 |
| MXI1 | RSPH3 | 0.724046 | 4 | 0 | 4 |
| MXI1 | TRIP4 | 0.722452 | 3 | 0 | 3 |
| MXI1 | EIF1AY | 0.720897 | 3 | 0 | 3 |
| MXI1 | NTAN1 | 0.720718 | 3 | 0 | 3 |
| MXI1 | C5orf51 | 0.718916 | 3 | 0 | 3 |
| MXI1 | ZNRF1 | 0.703275 | 3 | 0 | 3 |
| MXI1 | CCNYL1 | 0.70317 | 3 | 0 | 3 |
| MXI1 | MSRB3 | 0.702277 | 4 | 0 | 3 |
| MXI1 | KIAA0232 | 0.700962 | 10 | 0 | 10 |
| MXI1 | SORT1 | 0.700721 | 11 | 0 | 11 |
For details and further investigation, click here
